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About
What is Reactome ?
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Pathway Diagrams
Icon Info
Data Model
Computational inferred events
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p-S177,S181-IKBKB
Stable Identifier
R-HSA-202506
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phospho-IKK2, IKK-beta, IKKB, Inhibitor of nuclear factor kappa B kinase beta subunit
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of Immune System (Homo sapiens)
Diseases associated with the TLR signaling cascade (Homo sapiens)
IkBA variant leads to EDA-ID (Homo sapiens)
IkBA variant is not phosphorylated within IkBA:NF-kappaB (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Activation of NF-kappaB in B cells (Homo sapiens)
Activated IKK phosphorylates I-kappaB (Homo sapiens)
Active IKK complex [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
TAK1 associated with the CBM complex phosphorylates IKKbeta (Homo sapiens)
Active IKK complex [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
Activation of IKK complex (Homo sapiens)
p-S177,S181-IKKB:IKKA:NEMO [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Ubiquitination of NEMO by TRAF6 (Homo sapiens)
p-S177,S181-IKKB:IKKA:NEMO [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKKB:IKKA:pUb-NEMO [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKKB:IKKA:pUb-NEMO [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
IKBA is phosphorylated by Phospho IKKB kinase (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta (Homo sapiens)
p-S177,S181-IKKB:IKKA:NEMO [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Ubiquitination of NEMO by TRAF6 (Homo sapiens)
p-S177,S181-IKKB:IKKA:NEMO [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKKB:IKKA:pUb-NEMO [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKKB:IKKA:pUb-NEMO [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
ZBP1(DAI) mediated induction of type I IFNs (Homo sapiens)
RIP-mediated NFkB activation via ZBP1 (Homo sapiens)
Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
RIP1 facilitates IKK complex phosphorylation (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Homo sapiens)
TRAF6 mediated NF-kB activation (Homo sapiens)
Activation of IKK by MEKK1 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
Phosphorylation of IKK-beta by TAK1 (Homo sapiens)
p-S177,S181-IKKB:IKKA:NEMO [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Ubiquitination of NEMO by TRAF6 (Homo sapiens)
p-S177,S181-IKKB:IKKA:NEMO [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKKB:IKKA:pUb-NEMO [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKKB:IKKA:pUb-NEMO [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Homo sapiens)
NOD1/2 Signaling Pathway (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Toll-Like Receptors Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:Mal cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:Mal cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
MyD88:Mal cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAP3K8 (TPL2)-dependent MAPK1/3 activation (Homo sapiens)
IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
IKBKB phosphorylates TPL2 (MAP3K8) at Ser400 (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
TAK1 activates NFkB by phosphorylation and activation of IKKs complex (Homo sapiens)
Activated TAK1 mediates phosphorylation of the IKK Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
CYLD is phosphorylated by IKK (Homo sapiens)
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
NF-kB is activated and signals survival (Homo sapiens)
IKKbeta is activated (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Homo sapiens)
Phospho-IKK-beta homdimer [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Homo sapiens)
Phospho-IKK-beta homdimer [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Phospho-IKK-beta homdimer [cytosol] (Homo sapiens)
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14920 IKBKB
Gene Names
IKBKB, IKKB
Chain
chain:1-756
Reference Genes
BioGPS Gene:3551 IKBKB
COSMIC (genes):IKBKB IKBKB
CTD Gene:3551 IKBKB
dbSNP Gene:3551 IKBKB
ENSEMBL:ENSG00000104365 IKBKB
HGNC:5960 IKBKB
KEGG Gene (Homo sapiens):hsa:3551 IKBKB
Monarch:3551 IKBKB
NCBI Gene:3551 IKBKB
OMIM:603258 IKBKB
UCSC:O14920 IKBKB
Reference Transcript
RefSeq:NM_001242778.1 IKBKB
RefSeq:NM_001556.2 IKBKB
RefSeq:NM_001190720.2 IKBKB
Other Identifiers
0006220619
11730928_a_at
11730929_s_at
11730930_a_at
11745356_a_at
11746063_a_at
11746648_a_at
11750345_a_at
11752235_x_at
11753155_x_at
11755411_a_at
11755412_x_at
1249
17068462
209341_s_at
209342_s_at
211027_3p_s_at
211027_s_at
3551
35960_at
3BRT
3BRV
4447
44812_at
4E3C
4KIK
54675_at
54679_g_at
65461_r_at
8146171
A_23_P216188
A_24_P132518
A_24_P155058
AAC51860
AAC64675
AAD08997
AAH06231
AAT65965
AC083973
AF029684
AF031416
AF080158
AK302723
AK303528
AK316418
AY663108
BAG63942
BAG64556
BAH14789
BC006231
CAB004447
CCDS55228
CCDS56535
CCDS6128
ENSG00000104365
ENSP00000404920
ENSP00000430483
ENSP00000430684
ENSP00000430868
ENST00000416505
ENST00000519735
ENST00000520810
ENST00000520835
EntrezGene:3551
g13623262_3p_at
g13623262_3p_x_at
G3V105
g4185274_3p_a_at
GE62527
GO:0000166
GO:0002223
GO:0002479
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005829
GO:0006468
GO:0006954
GO:0007249
GO:0007252
GO:0008384
GO:0008385
GO:0009615
GO:0009653
GO:0009898
GO:0010803
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0019901
GO:0030866
GO:0033209
GO:0035509
GO:0035631
GO:0035666
GO:0038095
GO:0042325
GO:0042501
GO:0042803
GO:0043066
GO:0043123
GO:0045087
GO:0045121
GO:0045893
GO:0045944
GO:0046982
GO:0050852
GO:0051092
GO:0051403
GO:0070423
GO:0070498
GO:0071356
GO:0090002
GO:0097110
GO:1903140
GO:1903347
HGNC:5960
HPA001249
Hs.226573.0.S3_3p_a_at
Hs.226573.0.S3_3p_x_at
Hs.597664
IKBKB
IKBKB-202
IKBKB-212
IKBKB-217
IKBKB-218
ILMN_1727142
ILMN_2172588
IPR000626
IPR000719
IPR001245
IPR008271
IPR011009
IPR022007
IPR029071
MIM:603258
MIM:615592
NM_001190720
NM_001242778
NM_001556
NP_001177649
NP_001229707
NP_001547
NR_040009
PF00069
PF12179
PH_hs_0024951
PR00109
SM00220
SM01239
TC08000325.hg
TC08001896.hg
uc003xow.3
uc011lcq.3
uc011lcr.2
uc064mkh.1
UPI0000033729
UPI0000169E74
UPI00017A83C6
UPI0001DAFE40
XM_005273490
XM_005273491
XM_005273492
XM_005273493
XM_005273494
XM_005273496
XM_005273498
XM_011544517
XM_011544518
XM_011544519
XM_011544520
XM_011544521
XM_011544522
XM_017013396
XP_005273547
XP_005273548
XP_005273549
XP_005273550
XP_005273551
XP_005273553
XP_005273555
XP_011542819
XP_011542820
XP_011542821
XP_011542822
XP_011542823
XP_011542824
XP_016868885
XR_949402
Participant Of
hasComponent
Active IKK complex [cytosol]
IKBKG:p-S176,S180-CHUK:p-S177,S181-IKBKB [cytosol]
p-S177,S181-IKKB:IKKA:NEMO [cytosol]
p-S177,S181-IKKB:IKKA:pUb-NEMO [cytosol]
Phospho-IKK-beta homdimer [cytosol]
Other forms of this molecule
IKBKB [cytosol]
Inferred To
Homologues of p-S177,S181-IKBKB [cytosol] (Gallus gallus)
Homologues of p-S177,S181-IKBKB [cytosol] (Mus musculus)
Homologues of p-S177,S181-IKBKB [cytosol] (Sus scrofa)
phospho-p-S177,S181-IKBKB [cytosol] (Bos taurus)
phospho-p-S177,S181-IKBKB [cytosol] (Canis familiaris)
phospho-p-S177,S181-IKBKB [cytosol] (Danio rerio)
phospho-p-S177,S181-IKBKB [cytosol] (Drosophila melanogaster)
phospho-p-S177,S181-IKBKB [cytosol] (Gallus gallus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Sus scrofa)
phospho-p-S177,S181-IKBKB [cytosol] (Taeniopygia guttata)
phospho-p-S177,S181-IKBKB [cytosol] (Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 181
Coordinate
181
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 177
Coordinate
177
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001547.1
,
NP_001229707.1
,
NP_001177649.1
Brenda
2.7.11.10
ZINC - World Drugs
IKKB_HUMAN
ZINC - FDA approved
IKKB_HUMAN
ZINC - Substances
IKKB_HUMAN
ZINC target
O14920
ZINC - Biogenic
IKKB_HUMAN
PRO
O14920
PDB
4KIK
,
4E3C
,
3BRV
,
3BRT
GeneCards
O14920
DOCK Blaster
4E3C
,
3BRV
,
3BRT
,
4KIK
Orphanet
22826
ZINC - Predictions - Purchasable
IKKB_HUMAN
HMDB Protein
HMDBP01302
Interactors (27)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y6K9 IKBKG
10
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wro*447 [cytosol]
(R-HSA-5262978)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
K63polyUb-NEMO [cytosol]
(R-HSA-202530)
IKBKG [cytosol]
(R-HSA-168108)
0.979
34
UniProt:P25963 NFKBIA
10
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
NFKBIA [cytosol]
(R-HSA-168151)
K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol]
(R-HSA-5607659)
Ub-21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA E14* [cytosol]
(R-HSA-5228774)
NFKBIA W11* [cytosol]
(R-HSA-5228773)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
NFKBIA Q9* [cytosol]
(R-HSA-5228800)
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
0.969
27
UniProt:O15111 CHUK
3
p-T23-CHUK [cytosol]
(R-HSA-198615)
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
0.942
16
UniProt:O14920 IKBKB
2
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
IKBKB [cytosol]
(R-HSA-168114)
0.869
9
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.744
4
UniProt:P19838 NFKB1
8
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
0.722
3
UniProt:Q99558 MAP3K14
5
MAP3K14 [cytosol]
(R-HSA-168189)
Active NIK [cytosol]
(R-HSA-5607646)
p-MAP3K14 [cytosol]
(R-HSA-168187)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
0.713
3
UniProt:Q04206 RELA
5
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
0.692
3
UniProt:P67775 PPP2CA
4
PPP2CA [nucleoplasm]
(R-HSA-165978)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [cytosol]
(R-HSA-165971)
0.641
3
UniProt:P24772 B14
0.623
3
UniProt:Q9UGK3 STAP2
2
p-Y250-STAP2 [plasma membrane]
(R-HSA-8848079)
STAP2 [cytosol]
(R-HSA-8848028)
0.623
7
UniProt:Q92574 TSC1
2
TSC1 [cytosol]
(R-HSA-5672338)
TSC1 [plasma membrane]
(R-HSA-165169)
0.611
3
UniProt:Q14145 KEAP1
2
KEAP1 [cytosol]
(R-HSA-976038)
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
0.61
6
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.609
2
UniProt:P23396 RPS3
2
RPS3 [cytosol]
(R-HSA-72369)
RPS3 [nucleoplasm]
(R-HSA-6798714)
0.602
4
UniProt:Q5D1E7 ZC12A
0.591
4
UniProt:P08238 HSP90AB1
5
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
0.589
3
UniProt:P03409 TAX
0.589
3
UniProt:Q00610 CLTC
6
CLTC [trans-Golgi network membrane]
(R-HSA-5333703)
CLTC [cytosol]
(R-HSA-8856820)
CLTC [lysosomal membrane]
(R-HSA-2980660)
CLTC [endolysosome membrane]
(R-HSA-8870827)
CLTC [clathrin-coated endocytic vesicle membrane]
(R-HSA-5138450)
CLTC [plasma membrane]
(R-HSA-2980668)
0.589
2
UniProt:Q7Z434 MAVS
2
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
0.564
2
UniProt:Q92793 CREBBP
1
CREBBP [nucleoplasm]
(R-HSA-193545)
0.564
2
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.564
2
UniProt:O14965 AURKA
6
AURKA [nucleoplasm]
(R-HSA-4655443)
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [cytosol]
(R-HSA-2574832)
0.544
2
UniProt:Q86WI3 NLRC5
1
NLRC5 [cytosol]
(R-HSA-937324)
0.524
2
UniProt:Q9ULZ3 PYCARD
4
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [secretory granule lumen]
(R-HSA-6800957)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
PYCARD [cytosol]
(R-HSA-561191)
0.512
4
UniProt:P03230 LMP1
0.499
2
UniProt:Q9UKE5 TNIK
1
TNIK [cytosol]
(R-HSA-3214889)
0.499
2
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