p-S177,S181-IKBKB [cytosol]

Stable Identifier
R-HSA-202506
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phospho-IKK2, IKK-beta, IKKB, Inhibitor of nuclear factor kappa B kinase beta subunit
Icon
p-S177,S181-IKBKB [cytosol] icon
p-S177,S181-IKBKB [cytosol] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:O14920 IKBKB
Gene Names
IKBKB, IKKB
Chain
chain:1-756
Reference Genes
BioGPS Gene:3551 IKBKB
COSMIC (genes):IKBKB IKBKB
CTD Gene:3551 IKBKB
dbSNP Gene:3551 IKBKB
ENSEMBL:ENSG00000104365 IKBKB
ENSEMBL_homo_sapiens_GENE:ENSG00000104365 IKBKB
HGNC:5960 IKBKB
KEGG Gene (Homo sapiens):3551 IKBKB
Monarch:3551 IKBKB
NCBI Gene:3551 IKBKB
OMIM:603258 IKBKB
UCSC:O14920 IKBKB
Reference Transcript
Other Identifiers
0006220619
11730928_a_at
11730929_s_at
11730930_a_at
11745356_a_at
11746063_a_at
11746648_a_at
11750345_a_at
11752235_x_at
11753155_x_at
11755411_a_at
11755412_x_at
1249
17068462
209341_s_at
209342_s_at
211027_3p_s_at
211027_s_at
3096093
3096096
3096103
3096105
3096108
3096118
3096119
3096123
3096129
3096130
3096131
3096133
3096134
3096136
3096137
3096142
3096144
3096145
3096146
3096149
3096153
3096157
3096158
3096159
3096160
3096161
3096162
3096163
3096164
3551
35960_at
3BRT
3BRV
4447
44812_at
4E3C
4KIK
54675_at
54679_g_at
65461_r_at
8146171
A_23_P216188
A_24_P132518
A_24_P155058
AAC51860
AAC64675
AAD08997
AAH06231
AAT65965
AC083973
AF029684
AF031416
AF080158
AK302723
AK303528
AK316418
AY663108
BAG63942
BAG64556
BAH14789
BC006231
CAB004447
CCDS55228
CCDS56535
CCDS6128
E5RFG5
E5RFT3
E5RGA0
E5RGW5
E5RIW0
E5RJH2
ENSG00000104365
ENSP00000404920
ENSP00000430684
ENSP00000430868
ENST00000416505
ENST00000520810
ENST00000520835
EntrezGene:3551
G3V105
g4185274_3p_a_at
GE62527
GO:0000166
GO:0002223
GO:0002376
GO:0002479
GO:0002756
GO:0003674
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0006464
GO:0006468
GO:0006950
GO:0006954
GO:0007009
GO:0007010
GO:0007165
GO:0007249
GO:0007252
GO:0008150
GO:0008219
GO:0008384
GO:0008385
GO:0009058
GO:0009615
GO:0009898
GO:0010803
GO:0016020
GO:0016032
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0019899
GO:0019901
GO:0022607
GO:0030154
GO:0030866
GO:0032991
GO:0033209
GO:0034330
GO:0034641
GO:0035509
GO:0035631
GO:0035666
GO:0038095
GO:0042325
GO:0042802
GO:0042803
GO:0043066
GO:0043123
GO:0043167
GO:0043226
GO:0044403
GO:0045087
GO:0045121
GO:0045893
GO:0045944
GO:0046982
GO:0048856
GO:0050852
GO:0051092
GO:0051403
GO:0061024
GO:0070498
GO:0071356
GO:0072659
GO:0097110
GO:1903140
GO:1903347
HGNC:5960
HPA001249
Hs.226573.0.S3_3p_a_at
Hs.226573.0.S3_3p_x_at
IKBKB
IKBKB-202
IKBKB-217
IKBKB-218
ILMN_1727142
ILMN_2172588
IPR000626
IPR000719
IPR008271
IPR011009
IPR022007
IPR029071
J3KNS5
MIM:603258
MIM:615592
NM_001190720
NM_001242778
NM_001556
NP_001177649
NP_001229707
NP_001547
NR_040009
PF00069
PF12179
PH_hs_0024951
SM00220
SM01239
TC08000325.hg
TC08001896.hg
uc003xow.3
uc011lcq.3
uc011lcr.2
UPI0000033729
UPI00017A83C6
UPI0001DAFE40
XM_005273490
XM_005273491
XM_005273492
XM_005273493
XM_005273494
XM_005273496
XM_005273498
XM_011544517
XM_011544518
XM_011544519
XM_011544520
XM_011544521
XM_011544522
XM_017013396
XP_005273547
XP_005273548
XP_005273549
XP_005273550
XP_005273551
XP_005273553
XP_005273555
XP_011542819
XP_011542820
XP_011542821
XP_011542822
XP_011542823
XP_011542824
XP_016868885
Participant Of
hasComponent
Other forms of this molecule
IKBKB [cytosol]
IKBKB Q432Pfs*62 [cytosol]
Inferred To
phospho-p-S177,S181-IKBKB [cytosol] (Bos taurus)
phospho-p-S177,S181-IKBKB [cytosol] (Canis familiaris)
phospho-p-S177,S181-IKBKB [cytosol] (Danio rerio)
phospho-p-S177,S181-IKBKB [cytosol] (Gallus gallus)
phospho-p-S177,S181-IKBKB [cytosol] (Mus musculus)
phospho-p-S177,S181-IKBKB [cytosol] (Rattus norvegicus)
phospho-p-S177,S181-IKBKB [cytosol] (Sus scrofa)
phospho-p-S177,S181-IKBKB [cytosol] (Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 177
Coordinate
177
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 181
Coordinate
181
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
GeneCards
DOCK Blaster
BRENDA (Homo sapiens)
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (27)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9Y6K9 IKBKG  12 0.98 36
 UniProt:P25963 NFKBIA  10 0.969 27
 UniProt:O15111 CHUK  3 0.942 16
 UniProt:O14920 IKBKB  3 0.869 9
 UniProt:Q16543 CDC37  1 0.744 4
 UniProt:P19838 NFKB1  8 0.722 3
 UniProt:Q99558 MAP3K14  5 0.713 3
 UniProt:Q04206 RELA  6 0.692 3
 UniProt:P67775 PPP2CA  4 0.641 3
 UniProt:P24772 B14      0.623 3
 UniProt:Q9UGK3 STAP2  2 0.623 7
 UniProt:Q92574 TSC1  2 0.611 3
 UniProt:Q14145 KEAP1  2 0.61 6
 UniProt:P04637 TP53  27 0.609 2
 UniProt:P23396 RPS3  2 0.602 4
 UniProt:Q5D1E7 ZC12A      0.591 4
 UniProt:P03409 TAX      0.589 3
 UniProt:Q00610 CLTC  6 0.589 2
 UniProt:P08238 HSP90AB1  5 0.589 3
 UniProt:Q92793 CREBBP  3 0.564 2
 UniProt:Q12933 TRAF2  5 0.564 2
 UniProt:Q7Z434 MAVS  2 0.564 2
 UniProt:O14965 AURKA  6 0.544 2
 UniProt:Q86WI3 NLRC5  1 0.524 2
 UniProt:Q9ULZ3 PYCARD  4 0.512 4
 UniProt:P03230 LMP1      0.499 2
 UniProt:Q9UKE5 TNIK  1 0.499 2