Reactome | p-DVL2 [cytosol]

p-DVL2

Stable Identifier

R-HSA-201706

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

phospho-Dvl-2

Locations in the PathwayBrowser

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Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - ARRB bind GPCRs (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14641 DVL2

Gene Names

DVL2

Chain

chain:1-736

Reference Genes

BioGPS Gene:1856 DVL2

COSMIC (genes):DVL2 DVL2

CTD Gene:1856 DVL2

dbSNP Gene:1856 DVL2

ENSEMBL:ENSG00000004975 DVL2

HGNC:3086 DVL2

KEGG Gene (Homo sapiens):hsa:1856 DVL2

Monarch:1856 DVL2

NCBI Gene:1856 DVL2

OMIM:602151 DVL2

UCSC:O14641 DVL2

Reference Transcript

RefSeq:NM_004422.2 DVL2

Other Identifiers

0002350465

11720199_a_at

11748243_a_at

11749611_a_at

11749612_x_at

16840550

1856

21611

218759_at

22914

2REY

3743441

3743442

3743443

3743444

3743445

3743446

3743447

3743448

3743451

3743452

3743453

3743454

3743455

3743456

3743457

3743458

3743459

3743461

3743462

3743463

3CBX

3CBY

3CBZ

3CC0

4851107C_3p_at

4WIP

57532_at

5LNP

5SUY

5SUZ

63418_at

64732

8012079

9312

A_23_P55342

AAB65243

AAH14844

AAP88824

AF006012

BC014844

BT009822

CAB009312

CCDS11091

CH471108

DVL2

DVL2-201

EAW90244

EAW90245

ENSG00000004975

ENSP00000005340

ENST00000005340

EntrezGene:1856

g4758215_3p_at

GE62651

GO:0000902

GO:0001843

GO:0001934

GO:0003007

GO:0003151

GO:0003674

GO:0005109

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006366

GO:0006464

GO:0006950

GO:0007165

GO:0007267

GO:0007275

GO:0007379

GO:0007507

GO:0008150

GO:0008283

GO:0009058

GO:0009790

GO:0016020

GO:0016055

GO:0016235

GO:0016328

GO:0016604

GO:0019899

GO:0019901

GO:0019904

GO:0022007

GO:0022607

GO:0030136

GO:0030154

GO:0030674

GO:0031410

GO:0034613

GO:0034641

GO:0035282

GO:0035329

GO:0035556

GO:0035567

GO:0042802

GO:0043226

GO:0043507

GO:0043547

GO:0043621

GO:0044340

GO:0045177

GO:0045334

GO:0045893

GO:0048365

GO:0048646

GO:0048856

GO:0051091

GO:0051259

GO:0060029

GO:0060070

GO:0060071

GO:0061024

GO:0061098

GO:0065003

GO:0090090

GO:0090103

GO:0090179

GO:0090263

GO:0150012

GO:1904886

HGNC:3086

HPA021611

HPA022914

HPA064732

I3L0M7

I3L2N2

I3L2W9

ILMN_1652163

IPR000591

IPR001158

IPR001478

IPR003351

IPR008339

IPR008341

IPR015506

IPR024580

IPR029071

IPR036034

IPR036388

IPR036390

MIM:602151

NM_004422

NP_004413

PF00595

PF00610

PF00778

PF02377

PF12316

PH_hs_0031570

PR01760

PR01762

SM00021

SM00049

SM00228

TC17001079.hg

uc002gez.2

UPI0000000DE9

XM_005256502

XP_005256559

XR_001752441

XR_001752442

XR_001752443

Participant Of

hasMember

hasComponent

Other forms of this molecule

pp-DVL2 [cytosol]

p-DVL2 [clathrin-coated endocytic vesicle]

DVL2 [cytosol]

ub-DVL2 [cytosol]

Inferred To

Homologues of p-DVL2 [cytosol] (Caenorhabditis elegans)

Homologues of p-DVL2 [cytosol] (Sus scrofa)

Ghost homologue of p-DVL2 [cytosol] (Gallus gallus)

Ghost homologue of p-DVL2 [cytosol] (Taeniopygia guttata)

phospho-p-DVL2 [cytosol] (Bos taurus)

phospho-p-DVL2 [cytosol] (Caenorhabditis elegans)

phospho-p-DVL2 [cytosol] (Canis familiaris)

phospho-p-DVL2 [cytosol] (Danio rerio)

phospho-p-DVL2 [cytosol] (Drosophila melanogaster)

phospho-p-DVL2 [cytosol] (Mus musculus)

phospho-p-DVL2 [cytosol] (Rattus norvegicus)

phospho-p-DVL2 [cytosol] (Sus scrofa)

phospho-p-DVL2 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_004413.1

GeneCards

O14641

ZINC target

O14641

PRO

O14641

Orphanet

24497

PDB

2REY, 5SUZ, 5SUY, 4WIP, 3CBY, 3CC0, 5LNP, 3CBZ, 3CBX

Interactors (82)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.712	4
UniProt:O14641 DVL2	5	p-DVL2 [cytosol] (R-HSA-201706) pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.675	4
UniProt:Q9NYF0 DACT1	1	DACT1 [cytosol] (R-HSA-4641144)	0.646	6
UniProt:Q96CG3 TIFA			0.621	3
UniProt:A2A5Z6 Smurf2	2	Smurf2 [cytosol] (R-MMU-5632468) SMURF2 [nucleoplasm] (R-MMU-178202)	0.612	8
UniProt:Q9Z101 Pard6a	5	Pard6a [cell junction] (R-MMU-2161135) p-S345-Pard6a [cell junction] (R-MMU-2161131) phospho-p-S345-PARD6A [plasma membrane] (R-MMU-2134533) PARD6A [plasma membrane] (R-MMU-418187) PARD6A [cytosol] (R-MMU-420001)	0.612	6
UniProt:Q06630 MHR1			0.61	4
UniProt:P57078 RIPK4			0.602	4
UniProt:Q9GZV5 WWTR1	3	WWTR1 [cytosol] (R-HSA-1629773) WWTR1 [nucleoplasm] (R-HSA-1629775) p-S89-WWTR1 [cytosol] (R-HSA-2028665)	0.591	4
UniProt:O15169 AXIN1	11	AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) ub-AXIN1 [cytosol] (R-HSA-4641133) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512)	0.59	3
UniProt:P25054 APC	13	APC G1309Dfs4 [cytosol] (R-HSA-4791251) APC R1450 [cytosol] (R-HSA-5251499) APC F1197* [cytosol] (R-HSA-5246655) APC Q1338* [cytosol] (R-HSA-5246654) APC S811* [cytosol] (R-HSA-5246652) APC I1417 fs2 [cytosol] (R-HSA-5246651) APC E1554 [cytosol] (R-HSA-5246648) APC(1-777) [cytosol] (R-HSA-2976014) APC(778-2843) [cytosol] (R-HSA-2976013) APC [cytosol] (R-HSA-2976015) p-ub-APC [cytosol] (R-HSA-3009421) K63polyUb-APC [cytosol] (R-HSA-5246690) APC [nucleoplasm] (R-HSA-3361755)	0.564	2
UniProt:P39009	2	phospho-p-T68-CHEK2 [nucleoplasm] (R-SCE-113825) phospho-p-S,3T-CHEK2 [nucleoplasm] (R-SCE-5683784)	0.556	3
UniProt:Q08909 YO385			0.556	3
UniProt:P17214 EST1			0.556	3
UniProt:P40078 NSA2			0.556	3
UniProt:Q03338 PRP3			0.556	3
IntAct:EBI-11522238 CYC2			0.556	3
UniProt:Q03063 DIG1			0.556	3
UniProt:P48510	2	UBQLN2 [cytosol] (R-SCE-8866007) UBQLN1 [cytosol] (R-SCE-8866006)	0.556	3
UniProt:P53305 RT27			0.556	3
UniProt:P40956 GTS1			0.556	3
UniProt:Q12181 TAH18	1	TAH18 [cytosol] (R-SCE-2564779)	0.556	3
UniProt:P38128	6	phospho-p-T293,T300,T387-MEF2C [nucleoplasm] (R-SCE-448838) phospho-p-T312,T319-MEF2A [nucleoplasm] (R-SCE-448834) MEF2B [nucleoplasm] (R-SCE-445325-2) MEF2A [nucleoplasm] (R-SCE-199903) MEF2D [nucleoplasm] (R-SCE-445328) MEF2C [nucleoplasm] (R-SCE-199938)	0.556	3
UniProt:P40325 HUA1			0.556	3
UniProt:P33750 SOF1	2	DCAF13 [nucleoplasm] (R-SCE-6790673) SOF1 [nucleoplasm] (R-SCE-6790701)	0.556	3
UniProt:P40087 DDI1			0.556	3
UniProt:P32502	1	EIF2B2 [cytosol] (R-SCE-72519)	0.556	3
UniProt:Q12134 HUA2			0.556	3
UniProt:P38891	2	PXLP-BCAT2 [mitochondrial matrix] (R-SCE-70703) PXLP-BCAT1 [cytosol] (R-SCE-70698)	0.556	3
UniProt:P38339	3	ARAP2 [cytosol] (R-SCE-195180) ARAP3 [cytosol] (R-SCE-195185) ARAP1 [cytosol] (R-SCE-3211582)	0.556	3
UniProt:P40455 YIP2			0.556	3
UniProt:P36084 MUD2			0.556	3
UniProt:Q12389 DBP10			0.556	3
UniProt:Q12481 RRP36	1	RRP36 [nucleoplasm] (R-SCE-6790697)	0.556	3
UniProt:Q12083 MLH3			0.556	3
UniProt:P25372 TRX3			0.556	3
UniProt:P53617 NRD1			0.556	3
UniProt:Q12439 YO21A			0.556	3
UniProt:P05738	1	RPL9 [cytosol] (R-SCE-72492-2)	0.556	3
UniProt:P54787	3	RABGEF1 [cytosol] (R-SCE-8875419) RABGEF1 [early endosome membrane] (R-SCE-2029032) GAPVD1 [cytosol] (R-SCE-8871123)	0.556	3
UniProt:P39682 PRP39			0.556	3
UniProt:Q14134 TRIM29	1	TRIM29 [cytosol] (R-HSA-5624343)	0.556	5
UniProt:P40507 AIR1			0.556	3
UniProt:Q12476 AIR2			0.556	3
UniProt:P36575 ARRC			0.553	2
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.553	2
UniProt:P49674 CSNK1E	2	CSNK1E [nucleoplasm] (R-HSA-421306) CSNK1E [cytosol] (R-HSA-205877)	0.547	2
UniProt:Q5R2U3 Q5R2U3			0.524	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.508	3
UniProt:P49910 ZN165			0.508	2
UniProt:Q155Q3 DIXC1			0.499	2
UniProt:Q3B820 F161A			0.488	2
UniProt:Q8N5A5-3 ZGPAT			0.488	2
UniProt:Q53G59 KLHL12	1	KLHL12 [cytosol] (R-HSA-1504203)	0.488	2
UniProt:Q9P0T4 ZN581			0.488	2
UniProt:Q8IYA8 IHO1			0.488	2
UniProt:Q9H257-2 CARD9			0.488	2
UniProt:Q15750 TAB1	2	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238)	0.488	2
UniProt:Q86YD7 F90A1			0.488	2
UniProt:Q92530 PSMF1	2	PSMF1 [cytosol] (R-HSA-68818) PSMF1 [nucleoplasm] (R-HSA-174308)	0.488	2
UniProt:Q96T49 PP16B			0.488	2
UniProt:Q96GG9 DCUN1D1	2	DCUN1D1 [cytosol] (R-HSA-8951781) DCUN1D1 [nucleoplasm] (R-HSA-8952487)	0.488	2
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.488	2
UniProt:Q08117-2 AES			0.488	3
UniProt:Q9BWG6 SCNM1			0.488	2
UniProt:O00291 HIP1	1	HIP1 [cytosol] (R-HSA-8868153)	0.488	2
UniProt:Q8N7W2-2 BEND7			0.488	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.488	2
UniProt:Q6PJH3 Q6PJH3			0.488	2
UniProt:P19544-6 WT1			0.488	2
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.488	2
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2
UniProt:Q86VK4-3 ZNF410			0.488	2
UniProt:Q8TAP4-4 LMO3			0.488	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.488	2
UniProt:Q9H1M0 N62CL			0.488	2
UniProt:P0C206 REX			0.488	2
UniProt:O95551 TDP2	1	TDP2 [nucleoplasm] (R-HSA-5687253)	0.488	2
IntAct:EBI-11742485 SSX2IP			0.488	2
UniProt:P15622-3 ZNF250			0.488	2
UniProt:Q93062-3 RBPMS			0.488	2
UniProt:Q13895 BYSL	2	BYSL [cytosol] (R-HSA-6791518) BYSL [nucleoplasm] (R-HSA-6791526)	0.488	2