Reactome | p-DVL2 [cytosol]

p-DVL2

Stable Identifier

R-HSA-201706

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

phospho-Dvl-2

Locations in the PathwayBrowser

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Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - ARBB recruits GPCRs into clathrin-coated pits (Homo sapiens)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - ARRB bind GPCRs (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        ARRB-binding GPCRs [plasma membrane] (Homo sapiens)
        
        WNT5A:FZD4:p-DVL2 [plasma membrane] (Homo sapiens)
        
        p-DVL2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O14641 DVL2

Gene Names

DVL2

Chain

chain:1-736

Reference Genes

BioGPS Gene:1856 DVL2

COSMIC (genes):DVL2 DVL2

CTD Gene:1856 DVL2

dbSNP Gene:1856 DVL2

ENSEMBL:ENSG00000004975 DVL2

HGNC:3086 DVL2

KEGG Gene (Homo sapiens):hsa:1856 DVL2

Monarch:1856 DVL2

NCBI Gene:1856 DVL2

OMIM:602151 DVL2

UCSC:O14641 DVL2

Reference Transcript

RefSeq:NM_004422.2 DVL2

Other Identifiers

0002350465

11720199_a_at

11748243_a_at

11749611_a_at

11749612_x_at

16840550

1856

21611

218759_at

22914

2REY

3743441

3743442

3743443

3743444

3743445

3743446

3743447

3743448

3743451

3743452

3743453

3743454

3743455

3743456

3743457

3743458

3743459

3743461

3743462

3743463

3CBX

3CBY

3CBZ

3CC0

4851107C_3p_at

4WIP

57532_at

5LNP

5SUY

5SUZ

63418_at

64732

8012079

9312

A_23_P55342

AAB65243

AAH14844

AAP88824

AF006012

BC014844

BT009822

CAB009312

CCDS11091

CH471108

DVL2

DVL2-201

EAW90244

EAW90245

ENSG00000004975

ENSP00000005340

ENST00000005340

EntrezGene:1856

g4758215_3p_at

GE62651

GO:0000902

GO:0001843

GO:0001934

GO:0003007

GO:0003151

GO:0003674

GO:0005109

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006366

GO:0006461

GO:0006464

GO:0006950

GO:0007165

GO:0007267

GO:0007275

GO:0007379

GO:0007507

GO:0008150

GO:0008283

GO:0009058

GO:0009790

GO:0016020

GO:0016055

GO:0016235

GO:0016328

GO:0016604

GO:0019899

GO:0019901

GO:0019904

GO:0022007

GO:0022607

GO:0030136

GO:0030154

GO:0030674

GO:0031410

GO:0034613

GO:0034641

GO:0035282

GO:0035329

GO:0035556

GO:0035567

GO:0042802

GO:0043226

GO:0043507

GO:0043547

GO:0043621

GO:0044340

GO:0045177

GO:0045334

GO:0045893

GO:0048365

GO:0048646

GO:0048856

GO:0051091

GO:0051259

GO:0060029

GO:0060070

GO:0060071

GO:0061024

GO:0061098

GO:0065003

GO:0090090

GO:0090103

GO:0090179

GO:0090263

GO:0150012

GO:1904886

HGNC:3086

HPA021611

HPA022914

HPA064732

ILMN_1652163

IPR000591

IPR001158

IPR001478

IPR003351

IPR008339

IPR008341

IPR015506

IPR024580

IPR029071

IPR036034

IPR036388

IPR036390

MIM:602151

NM_004422

NP_004413

PF00595

PF00610

PF00778

PF02377

PF12316

PH_hs_0031570

PR01760

PR01762

SM00021

SM00049

SM00228

TC17001079.hg

uc002gez.2

UPI0000000DE9

XM_005256502

XP_005256559

XR_001752441

XR_001752442

XR_001752443

Participant Of

hasMember

hasComponent

Other forms of this molecule

pp-DVL2 [cytosol]

p-DVL2 [clathrin-coated endocytic vesicle]

DVL2 [cytosol]

ub-DVL2 [cytosol]

Inferred To

Homologues of p-DVL2 [cytosol] (Caenorhabditis elegans)

Homologues of p-DVL2 [cytosol] (Sus scrofa)

Ghost homologue of p-DVL2 [cytosol] (Gallus gallus)

Ghost homologue of p-DVL2 [cytosol] (Taeniopygia guttata)

phospho-p-DVL2 [cytosol] (Bos taurus)

phospho-p-DVL2 [cytosol] (Caenorhabditis elegans)

phospho-p-DVL2 [cytosol] (Canis familiaris)

phospho-p-DVL2 [cytosol] (Danio rerio)

phospho-p-DVL2 [cytosol] (Drosophila melanogaster)

phospho-p-DVL2 [cytosol] (Mus musculus)

phospho-p-DVL2 [cytosol] (Rattus norvegicus)

phospho-p-DVL2 [cytosol] (Sus scrofa)

phospho-p-DVL2 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

NP_004413.1

GeneCards

O14641

DOCK Blaster

2REY, 3CC0, 3CBZ, 5SUY, 4WIP, 5LNP, 3CBY, 3CBX, 5SUZ

ZINC target

O14641

PRO

O14641

Orphanet

24497

PDB

2REY, 5LNP, 3CBY, 5SUZ, 3CC0, 4WIP, 3CBX, 3CBZ, 5SUY

Interactors (82)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.712	4
UniProt:O14641 DVL2	5	p-DVL2 [cytosol] (R-HSA-201706) pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.675	4
UniProt:Q9NYF0 DACT1	1	DACT1 [cytosol] (R-HSA-4641144)	0.646	6
UniProt:Q96CG3 TIFA			0.621	3
UniProt:Q9Z101 Pard6a	5	Pard6a [cell junction] (R-MMU-2161135) p-S345-Pard6a [cell junction] (R-MMU-2161131) phospho-p-S345-PARD6A [plasma membrane] (R-MMU-2134533) PARD6A [plasma membrane] (R-MMU-418187) PARD6A [cytosol] (R-MMU-420001)	0.612	6
UniProt:A2A5Z6 Smurf2	2	Smurf2 [cytosol] (R-MMU-5632468) SMURF2 [nucleoplasm] (R-MMU-178202)	0.612	8
UniProt:Q06630 MHR1			0.61	4
UniProt:P57078 RIPK4			0.602	4
UniProt:Q9GZV5 WWTR1	3	p-S89-WWTR1 [cytosol] (R-HSA-2028665) WWTR1 [cytosol] (R-HSA-1629773) WWTR1 [nucleoplasm] (R-HSA-1629775)	0.591	4
UniProt:O15169 AXIN1	11	AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 P255S [cytosol] (R-HSA-5251505) ub-AXIN1 [cytosol] (R-HSA-4641133) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 [cytosol] (R-HSA-195249) p-T519,S524,S531-AXIN1 [cytosol] (R-HSA-206040) RibC-AXIN1 [cytosol] (R-HSA-3640841)	0.59	3
UniProt:P25054 APC	13	APC G1309Dfs4 [cytosol] (R-HSA-4791251) APC R1450 [cytosol] (R-HSA-5251499) APC F1197* [cytosol] (R-HSA-5246655) APC Q1338* [cytosol] (R-HSA-5246654) APC S811* [cytosol] (R-HSA-5246652) APC I1417 fs2 [cytosol] (R-HSA-5246651) APC E1554 [cytosol] (R-HSA-5246648) APC(1-777) [cytosol] (R-HSA-2976014) APC(778-2843) [cytosol] (R-HSA-2976013) APC [cytosol] (R-HSA-2976015) p-ub-APC [cytosol] (R-HSA-3009421) K63polyUb-APC [cytosol] (R-HSA-5246690) APC [nucleoplasm] (R-HSA-3361755)	0.564	2
UniProt:P39009 DUN1			0.556	3
UniProt:Q08909 YO385			0.556	3
UniProt:P17214 EST1			0.556	3
UniProt:P40078 NSA2			0.556	3
UniProt:Q03338 PRP3			0.556	3
IntAct:EBI-11522238 CYC2			0.556	3
UniProt:Q03063 DIG1			0.556	3
UniProt:P48510	2	UBQLN2 [cytosol] (R-SCE-8866007) UBQLN1 [cytosol] (R-SCE-8866006)	0.556	3
UniProt:P53305 RT27			0.556	3
UniProt:P40956 GTS1			0.556	3
UniProt:Q12181 TAH18	1	TAH18 [cytosol] (R-SCE-2564779)	0.556	3
UniProt:P38128	6	phospho-p-T293,T300,T387-MEF2C [nucleoplasm] (R-SCE-448838-2) phospho-p-T312,T319-MEF2A [nucleoplasm] (R-SCE-448834-2) MEF2B [nucleoplasm] (R-SCE-445325-2) MEF2D [nucleoplasm] (R-SCE-445328-2) MEF2A [nucleoplasm] (R-SCE-199903-2) MEF2C [nucleoplasm] (R-SCE-199938-2)	0.556	3
UniProt:P40325 HUA1			0.556	3
UniProt:P33750 SOF1	2	DCAF13 [nucleoplasm] (R-SCE-6790673) SOF1 [nucleoplasm] (R-SCE-6790701)	0.556	3
UniProt:P40087 DDI1			0.556	3
UniProt:P32502	1	EIF2B2 [cytosol] (R-SCE-72519)	0.556	3
UniProt:Q12134 HUA2			0.556	3
UniProt:P38891	2	PXLP-BCAT2 [mitochondrial matrix] (R-SCE-70703-2) PXLP-BCAT1 [cytosol] (R-SCE-70698-2)	0.556	3
UniProt:P38339	6	ARAP2 [cytosol] (R-SCE-195180) ARAP3 [cytosol] (R-SCE-195185) ARHGAP5 [cytosol] (R-SCE-195084) ARAP1 [cytosol] (R-SCE-3211582) ARHGAP35 [cytosol] (R-SCE-195118) phospho-p-Y1105-ARHGAP35 [cytosol] (R-SCE-8849056)	0.556	3
UniProt:P40455 YIP2			0.556	3
UniProt:P36084 MUD2			0.556	3
UniProt:Q12389 DBP10			0.556	3
UniProt:Q12481 RRP36	1	RRP36 [nucleoplasm] (R-SCE-6790697)	0.556	3
UniProt:Q12083 MLH3			0.556	3
UniProt:P25372 TRX3			0.556	3
UniProt:P53617 NRD1			0.556	3
UniProt:Q12439 YO21A			0.556	3
UniProt:P05738	1	RPL9 [cytosol] (R-SCE-72492)	0.556	3
UniProt:P54787	3	RABGEF1 [cytosol] (R-SCE-8875419) RABGEF1 [early endosome membrane] (R-SCE-2029032) GAPVD1 [cytosol] (R-SCE-8871123)	0.556	3
UniProt:P39682 PRP39			0.556	3
UniProt:Q14134 TRIM29	1	TRIM29 [cytosol] (R-HSA-5624343)	0.556	5
UniProt:P40507 AIR1			0.556	3
UniProt:Q12476 AIR2			0.556	3
UniProt:P36575 ARRC			0.553	2
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.553	2
UniProt:P49674 CSNK1E	2	CSNK1E [nucleoplasm] (R-HSA-421306) CSNK1E [cytosol] (R-HSA-205877)	0.547	2
UniProt:Q5R2U3 Q5R2U3			0.524	2
UniProt:P49910 ZN165			0.508	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.508	3
UniProt:Q155Q3 DIXC1			0.499	2
UniProt:Q3B820 F161A			0.488	2
UniProt:Q8N5A5-3 ZGPAT			0.488	2
UniProt:Q53G59 KLHL12	1	KLHL12 [cytosol] (R-HSA-1504203)	0.488	2
UniProt:Q9P0T4 ZN581			0.488	2
UniProt:Q8IYA8 IHO1			0.488	2
UniProt:Q9H257-2 CARD9			0.488	2
UniProt:Q15750 TAB1	2	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238)	0.488	2
UniProt:Q86YD7 F90A1			0.488	2
UniProt:Q92530 PSMF1	2	PSMF1 [cytosol] (R-HSA-68818) PSMF1 [nucleoplasm] (R-HSA-174308)	0.488	2
UniProt:Q96GG9 DCUN1D1	2	DCUN1D1 [cytosol] (R-HSA-8951781) DCUN1D1 [nucleoplasm] (R-HSA-8952487)	0.488	2
UniProt:Q96T49 PP16B			0.488	2
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.488	2
UniProt:Q08117-2 AES			0.488	3
UniProt:Q9BWG6 SCNM1			0.488	2
UniProt:O00291 HIP1	1	HIP1 [cytosol] (R-HSA-8868153)	0.488	2
UniProt:Q8N7W2-2 BEND7			0.488	2
UniProt:Q6PJH3 Q6PJH3			0.488	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.488	2
UniProt:P19544-6 WT1			0.488	2
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2
UniProt:Q86VK4-3 ZNF410			0.488	2
UniProt:Q8TAP4-4 LMO3			0.488	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.488	2
UniProt:Q9H1M0 N62CL			0.488	2
UniProt:P0C206 REX			0.488	2
UniProt:O95551 TDP2	1	TDP2 [nucleoplasm] (R-HSA-5687253)	0.488	2
IntAct:EBI-11742485 SSX2IP			0.488	2
UniProt:P15622-3 ZNF250			0.488	2
UniProt:Q93062-3 RBPMS			0.488	2
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.488	2
UniProt:Q13895 BYSL	2	BYSL [cytosol] (R-HSA-6791518) BYSL [nucleoplasm] (R-HSA-6791526)	0.488	2