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RYBP [nucleoplasm]
Stable Identifier
R-HSA-8937975
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
RING1 and YY1-binding protein, RYBP_HUMAN, Apoptin-associating protein 1, APAP-1, DED-associated factor, DED-associated factor YY1 and E4TF1-associated factor 1, DEDAF, YEAF1
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)
PRC1.6 [nucleoplasm] (Homo sapiens)
RYBP,YAF2 [nucleoplasm] (Homo sapiens)
RYBP [nucleoplasm] (Homo sapiens)
E2F6 binds the PRC1 complex (Homo sapiens)
E2F6:(TFDP1,TFDP2):PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
RYBP [nucleoplasm] (Homo sapiens)
PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
RYBP [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
RUNX1 binds PRC1 complexes (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.5 [nucleoplasm] (Homo sapiens)
RYBP,YAF2 [nucleoplasm] (Homo sapiens)
RYBP [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.5 [nucleoplasm] (Homo sapiens)
RYBP,YAF2 [nucleoplasm] (Homo sapiens)
RYBP [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N488 RYBP
Gene Names
RYBP, DEDAF, YEAF1
Chain
chain:1-228
Reference Genes
BioGPS Gene:23429 RYBP
COSMIC (genes):RYBP RYBP
CTD Gene:23429 RYBP
dbSNP Gene:23429 RYBP
ENSEMBL:ENSG00000163602 RYBP
HGNC:10480 RYBP
KEGG Gene (Homo sapiens):23429 RYBP
Monarch:23429 RYBP
NCBI Gene:23429 RYBP
OMIM:607535 RYBP
UCSC:Q8N488 RYBP
Reference Transcript
RefSeq:NM_012234.6 RYBP
Other Identifiers
0005080056
0104150427
11717538_a_at
11717539_at
11717540_a_at
11757579_s_at
16956244
201844_s_at
201845_s_at
201846_s_at
23429
242719_at
2682429
2682431
2682433
2682435
2682437
2682438
2682439
2682441
2682442
2682470
37732_at
46926_at
8088820
86944_at
A_23_P305711
A_24_P114459
A_32_P101775
GE473221
GE53758
GE570275
GO:0000122
GO:0003674
GO:0003677
GO:0003712
GO:0003714
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0006355
GO:0006464
GO:0006915
GO:0007049
GO:0007275
GO:0008150
GO:0008219
GO:0009056
GO:0009058
GO:0031519
GO:0032435
GO:0032991
GO:0034641
GO:0035518
GO:0043065
GO:0043167
GO:0043226
GO:0045893
GO:0046872
GO:0048856
GO:0051276
GO:0070317
HMNXSV003039644
Hs.137187.0.A1_3p_at
Hs.7910.0.S2_3p_a_at
ILMN_1721842
PH_hs_0000817
TC03001554.hg
g6714542_3p_a_at
g6912639_3p_a_at
Participates
as a component of
PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
as a member of
RYBP,YAF2 [nucleoplasm] (Homo sapiens)
Inferred To
RYBP [nucleoplasm]
(Bos taurus)
RYBP [nucleoplasm]
(Canis familiaris)
RYBP [nucleoplasm]
(Drosophila melanogaster)
RYBP [nucleoplasm]
(Gallus gallus)
RYBP [nucleoplasm]
(Sus scrofa)
rybp [nucleoplasm]
(Xenopus tropicalis)
Rybp [nucleoplasm]
(Mus musculus)
Rybp [nucleoplasm]
(Rattus norvegicus)
rybpb [nucleoplasm]
(Danio rerio)
Cross References
RefSeq
NP_036366.3
OpenTargets
ENSG00000163602
GeneCards
Q8N488
HPA
ENSG00000163602-RYBP
Ensembl
ENSP00000419494
,
ENST00000477973
,
ENSG00000163602
PRO
Q8N488
Pharos - Targets
Q8N488
PDB
3IXS
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BYE7 PCGF6
1
PCGF6 [nucleoplasm]
(R-HSA-8953572)
0.725
6
UniProt:P35637 FUS
1
FUS [nucleoplasm]
(R-HSA-72040)
0.666
4
UniProt:O75461 E2F6
2
E2F6 [nucleoplasm]
(R-HSA-8953089)
p-S12-E2F6 [nucleoplasm]
(R-HSA-9007536)
0.659
3
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.643
4
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.643
4
UniProt:P35227 PCGF2
1
PCGF2 [nucleoplasm]
(R-HSA-389115)
0.643
4
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.623
4
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.616
11
UniProt:P0CG48 UBC
20
UBC(381-456) [endocytic vesicle membrane]
(R-HSA-939218)
UBC(533-608) [endocytic vesicle membrane]
(R-HSA-939220)
UBC(609-684) [endocytic vesicle membrane]
(R-HSA-939223)
UBC(457-532) [endocytic vesicle membrane]
(R-HSA-939195)
UBC(153-228) [endocytic vesicle membrane]
(R-HSA-939194)
UBC(305-380) [endocytic vesicle membrane]
(R-HSA-939228)
UBC(229-304) [endocytic vesicle membrane]
(R-HSA-939177)
UBC(77-152) [endocytic vesicle membrane]
(R-HSA-939210)
UBC(1-76) [endocytic vesicle membrane]
(R-HSA-939245)
Ub-566-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783166)
Ub-338-UBC(305-380) [mitochondrial outer membrane]
(R-HSA-6783121)
Ub-186-UBC(153-228) [mitochondrial outer membrane]
(R-HSA-6783154)
Ub-262-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783028)
Ub-414-UBC(381-456) [mitochondrial outer membrane]
(R-HSA-6783061)
Ub-110-UBC(77-152) [mitochondrial outer membrane]
(R-HSA-6783158)
Ub-642-UBC(609-684) [mitochondrial outer membrane]
(R-HSA-6783182)
Ub-33-UBC(1-76) [mitochondrial outer membrane]
(R-HSA-6783073)
Ub-488-UBC(457-532) [mitochondrial outer membrane]
(R-HSA-6783078)
Ub-291-UBC(229-304) [mitochondrial outer membrane]
(R-HSA-6783193)
Ub-595-UBC(533-608) [mitochondrial outer membrane]
(R-HSA-6783130)
0.602
3
UniProt:P78333 GPC5
20
GPI-cleaved GPC5 [extracellular region]
(R-HSA-5362356)
GPI-GPC5 [plasma membrane]
(R-HSA-5362430)
GPC5(25-?) [plasma membrane]
(R-HSA-2090042)
GPC5(25-?) [lysosomal lumen]
(R-HSA-2090047)
HS(6)-GPC5 [lysosomal lumen]
(R-HSA-2090029)
HS(6)-GPC5 [Golgi lumen]
(R-HSA-2076329)
HS(5)-GPC5 [Golgi lumen]
(R-HSA-2076457)
Heparan-GPC5 [Golgi lumen]
(R-HSA-2076472)
Heparan(1)-GPC5 [Golgi lumen]
(R-HSA-2076584)
Heparan(2)-GPC5 [Golgi lumen]
(R-HSA-2076482)
Heparan(3)-GPC5 [Golgi lumen]
(R-HSA-2076376)
Heparan(4)-GPC5 [Golgi lumen]
(R-HSA-2076556)
HS(1)-GPC5 [Golgi lumen]
(R-HSA-2076486)
HS(4)-GPC5 [plasma membrane]
(R-HSA-2076696)
HS(6)-GPC5 [plasma membrane]
(R-HSA-2076676)
HS(2)-GPC5 [plasma membrane]
(R-HSA-2076649)
HS(1)-GPC5 [plasma membrane]
(R-HSA-2076689)
HS(3)-GPC5 [plasma membrane]
(R-HSA-2076628)
HS(5)-GPC5 [plasma membrane]
(R-HSA-2076646)
XylS-GPC5(25-?) [Golgi lumen]
(R-HSA-2064160)
0.556
3
UniProt:P02545 LMNA
3
LMNA(1-664) [nucleoplasm]
(R-HSA-535479)
LMNA(1-567)-RAF1(279-648) fusion [cytosol]
(R-HSA-6802399)
LMNA(1-567)-p-RAF1(279-648) fusion [cytosol]
(R-HSA-6802537)
0.556
3
UniProt:P07196 NEFL
1
NEFL [cytosol]
(R-HSA-432284)
0.556
3
UniProt:P00441 SOD1
5
SOD1 [extracellular region]
(R-HSA-350705)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
SOD1 [cytosol]
(R-HSA-350697)
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
0.556
3
UniProt:Q96JC9 EAF1
1
EAF1 [nucleoplasm]
(R-HSA-8932787)
0.556
3
UniProt:P37840 SNCA
4
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [extracellular region]
(R-HSA-976954)
SNCA [cytosol]
(R-HSA-5658500)
Ub-SNCA [cytosol]
(R-HSA-5660754)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
9
UniProt:P0CG47 UBB
20
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-110-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-186-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-182-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:Q16143 SNCB
1
SNCB [cytosol]
(R-HSA-5660390)
0.556
3
UniProt:Q92597 NDRG1
1
NDRG1 [cytosol]
(R-HSA-5628834)
0.556
3
UniProt:Q00403 GTF2B
1
GTF2B [nucleoplasm]
(R-HSA-65888)
0.556
3
UniProt:Q969R5 L3MBTL2
2
L3MBTL2 [nucleoplasm]
(R-HSA-6804477)
polySUMO2-K675,K700-L3MBTL2 [nucleoplasm]
(R-HSA-6804480)
0.527
2
UniProt:Q14186 TFDP1
1
TFDP1 [nucleoplasm]
(R-HSA-68652)
0.527
2
UniProt:P63208 SKP1
2
SKP1 [nucleoplasm]
(R-HSA-187538)
SKP1 [cytosol]
(R-HSA-174150)
0.527
2
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