Reactome | RYBP [nucleoplasm]

RYBP [nucleoplasm]

Stable Identifier

R-HSA-8937975

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

RING1 and YY1-binding protein, RYBP_HUMAN, Apoptin-associating protein 1, APAP-1, DED-associated factor, DED-associated factor YY1 and E4TF1-associated factor 1, DEDAF, YEAF1

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by E2F6 (Homo sapiens)
      - E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)
        
        PRC1.6 [nucleoplasm] (Homo sapiens)
        
        RYBP,YAF2 [nucleoplasm] (Homo sapiens)
        
        RYBP [nucleoplasm] (Homo sapiens)
      - E2F6 binds the PRC1 complex (Homo sapiens)
        
        E2F6:(TFDP1,TFDP2):PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
        
        PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
        
        RYBP [nucleoplasm] (Homo sapiens)
        
        PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)
        
        RYBP [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        RUNX1 binds PRC1 complexes (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.5 [nucleoplasm] (Homo sapiens)
        
        RYBP,YAF2 [nucleoplasm] (Homo sapiens)
        
        RYBP [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.5 [nucleoplasm] (Homo sapiens)
        
        RYBP,YAF2 [nucleoplasm] (Homo sapiens)
        
        RYBP [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N488 RYBP

Gene Names

RYBP, DEDAF, YEAF1

Chain

chain:1-228

Reference Genes

BioGPS Gene:23429 RYBP

COSMIC (genes):RYBP RYBP

CTD Gene:23429 RYBP

dbSNP Gene:23429 RYBP

ENSEMBL:ENSG00000163602 RYBP

ENSEMBL:ENSG00000163602.12 RYBP

ENSEMBL:ENSG00000281766.3 RYBP

HGNC:10480 RYBP

KEGG Gene (Homo sapiens):23429 RYBP

Monarch:23429 RYBP

NCBI Gene:23429 RYBP

OMIM:607535 RYBP

UCSC:Q8N488 RYBP

Reference Transcript

RefSeq:NM_012234.6 RYBP

Other Identifiers

11717538_a_at

11717539_at

11717540_a_at

11757579_s_at

16956244

201844_PM_s_at

201844_s_at

201845_PM_s_at

201845_s_at

201846_PM_s_at

201846_s_at

23429

242719_PM_at

242719_at

2682429

2682431

2682433

2682435

2682437

2682438

2682439

2682441

2682442

2682470

37732_at

46926_at

8088820

86944_at

A_23_P305711

A_24_P114459

A_32_P101775

GE473221

GE53758

GE570275

GO:0000122

GO:0003676

GO:0003677

GO:0003712

GO:0003714

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0006915

GO:0012501

GO:0030163

GO:0031519

GO:0032435

GO:0043065

GO:0043226

GO:0045893

GO:0046872

GO:0140110

HMNXSV003039644

Hs.137187.0.A1_3p_at

Hs.7910.0.S2_3p_a_at

ILMN_1721842

PH_hs_0000817

TC03001554.hg

g6714542_3p_a_at

g6912639_3p_a_at

Participates

as a component of

PRC1 (BMI1,PCGF2:RYBP:RING1:PHC1,PHC3) [nucleoplasm] (Homo sapiens)

as a member of

RYBP,YAF2 [nucleoplasm] (Homo sapiens)

Inferred To

RYBP [nucleoplasm] (Bos taurus)

RYBP [nucleoplasm] (Canis familiaris)

RYBP [nucleoplasm] (Drosophila melanogaster)

RYBP [nucleoplasm] (Gallus gallus)

RYBP [nucleoplasm] (Sus scrofa)

rybp [nucleoplasm] (Xenopus tropicalis)

LOC120102351 [nucleoplasm] (Rattus norvegicus)

Rybp [nucleoplasm] (Mus musculus)

rybpb [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_036366.3

OpenTargets

ENSG00000163602

GeneCards

Q8N488

HPA

ENSG00000163602-RYBP

Ensembl

ENSP00000419494, ENSG00000163602, ENST00000477973

PRO

Q8N488

Pharos - Targets

Q8N488

PDB

3IXS

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BYE7 PCGF6	1	PCGF6 [nucleoplasm] (R-HSA-8953572)	0.725	6
UniProt:O75461 E2F6	2	E2F6 [nucleoplasm] (R-HSA-8953089) p-S12-E2F6 [nucleoplasm] (R-HSA-9007536)	0.659	3
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.643	4
UniProt:P35227 PCGF2	1	PCGF2 [nucleoplasm] (R-HSA-389115)	0.643	4
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.643	4
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.623	4
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.616	11
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.602	3
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-215-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783002) Ub-63-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783148) Ub-139-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783012) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070)	0.556	3
UniProt:Q92597 NDRG1	1	NDRG1 [cytosol] (R-HSA-5628834)	0.556	3
UniProt:P78333 GPC5	20	GPI-cleaved GPC5 [extracellular region] (R-HSA-5362356) GPI-GPC5 [plasma membrane] (R-HSA-5362430) GPC5(25-?) [lysosomal lumen] (R-HSA-2090047) HS(6)-GPC5 [lysosomal lumen] (R-HSA-2090029) HS(2)-GPC5 [Golgi lumen] (R-HSA-2076459) HS(3)-GPC5 [Golgi lumen] (R-HSA-2076544) HS(4)-GPC5 [Golgi lumen] (R-HSA-2076518) HS(6)-GPC5 [Golgi lumen] (R-HSA-2076329) HS(5)-GPC5 [Golgi lumen] (R-HSA-2076457) HS(1)-GPC5 [Golgi lumen] (R-HSA-2076486) Heparan(4)-GPC5 [Golgi lumen] (R-HSA-2076556) Heparan(3)-GPC5 [Golgi lumen] (R-HSA-2076376) Heparan(2)-GPC5 [Golgi lumen] (R-HSA-2076482) Heparan(1)-GPC5 [Golgi lumen] (R-HSA-2076584) HS(4)-GPC5 [plasma membrane] (R-HSA-2076696) HS(6)-GPC5 [plasma membrane] (R-HSA-2076676) HS(2)-GPC5 [plasma membrane] (R-HSA-2076649) HS(1)-GPC5 [plasma membrane] (R-HSA-2076689) HS(3)-GPC5 [plasma membrane] (R-HSA-2076628) HS(5)-GPC5 [plasma membrane] (R-HSA-2076646)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:Q96JC9 EAF1	1	EAF1 [nucleoplasm] (R-HSA-8932787)	0.556	3
UniProt:P02545 LMNA	3	LMNA(1-646) [nuclear envelope] (R-HSA-535479) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537)	0.556	3
UniProt:P00441 SOD1	5	SOD1 [extracellular region] (R-HSA-350705) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [cytosol] (R-HSA-3299726)	0.556	3
UniProt:Q16143 SNCB	1	SNCB [cytosol] (R-HSA-5660390)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.556	3
UniProt:Q00403 GTF2B	1	GTF2B [nucleoplasm] (R-HSA-65888)	0.556	3
UniProt:Q01658 DR1	1	DR1 [nucleoplasm] (R-HSA-3662280)	0.556	3
UniProt:Q14186 TFDP1	1	TFDP1 [nucleoplasm] (R-HSA-68652)	0.527	2
UniProt:Q969R5 L3MBTL2	2	L3MBTL2 [nucleoplasm] (R-HSA-6804477) polySUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480)	0.527	2
UniProt:P63208 SKP1	2	SKP1 [nucleoplasm] (R-HSA-187538) SKP1 [cytosol] (R-HSA-174150)	0.527	2

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