EP300 [nucleoplasm]

Stable Identifier
R-HSA-381325
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p300, Histone acetyltransferase p300, EP300_HUMAN, KAT3B
Icon
EP300 [nucleoplasm] icon
EP300 [nucleoplasm] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:Q09472 EP300
Gene Names
EP300, P300
Chain
initiator methionine:, chain:2-2414
Reference Genes
BioGPS Gene:2033 EP300
COSMIC (genes):EP300 EP300
CTD Gene:2033 EP300
dbSNP Gene:2033 EP300
ENSEMBL:ENSG00000100393 EP300
HGNC:3373 EP300
KEGG:hsa:2033 EP300
Monarch:2033 EP300
NCBI Gene:2033 EP300
OMIM:602700 EP300
UCSC:Q09472 EP300
Reference Transcript
Other Identifiers
11725127_at
16930534
17119320
202221_PM_s_at
202221_s_at
2033
213579_PM_s_at
213579_s_at
33896_at
3946616
3946617
3946618
3946619
3946627
3946629
3946630
3946631
3946632
3946634
3946637
3946638
3946640
3946641
3946642
3946643
3946644
3946645
3946646
3946647
3946648
3946649
3946651
3946652
3946653
3946654
3946655
3946656
3946657
3946658
3946659
3946660
3946661
3946662
3946663
3946664
3946665
3946666
3946667
3946669
3946671
3946672
3946673
3946674
3946675
3946676
3946677
3946678
3946679
3946681
3946682
3946683
3946684
3946685
3946686
3946687
3946688
3946689
3946690
3946691
3946693
551_at
8073345
A_14_P108084
A_14_P127141
A_23_P40693
A_24_P7887
GE58850
GO:0000122
GO:0000123
GO:0000785
GO:0001221
GO:0001223
GO:0001666
GO:0001756
GO:0001966
GO:0002039
GO:0002209
GO:0002223
GO:0002376
GO:0003677
GO:0003682
GO:0003684
GO:0003712
GO:0003713
GO:0003723
GO:0003824
GO:0004402
GO:0004468
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0006110
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0006473
GO:0006475
GO:0006915
GO:0007249
GO:0007399
GO:0007507
GO:0007519
GO:0007611
GO:0007623
GO:0008013
GO:0008092
GO:0008270
GO:0009887
GO:0010484
GO:0010485
GO:0010506
GO:0010507
GO:0010628
GO:0010821
GO:0010976
GO:0012501
GO:0016407
GO:0016740
GO:0016746
GO:0016922
GO:0018076
GO:0018393
GO:0018394
GO:0030154
GO:0030183
GO:0030220
GO:0030324
GO:0030511
GO:0031333
GO:0031490
GO:0031648
GO:0031669
GO:0032991
GO:0032993
GO:0034212
GO:0034644
GO:0035264
GO:0035855
GO:0036268
GO:0042307
GO:0042771
GO:0043226
GO:0043627
GO:0043923
GO:0043993
GO:0044013
GO:0044017
GO:0044877
GO:0045444
GO:0045721
GO:0045815
GO:0045893
GO:0045944
GO:0046427
GO:0046872
GO:0048156
GO:0048511
GO:0048856
GO:0050681
GO:0050821
GO:0050877
GO:0051059
GO:0051091
GO:0051604
GO:0060090
GO:0060325
GO:0060765
GO:0061629
GO:0061733
GO:0061920
GO:0061921
GO:0071233
GO:0090043
GO:0097157
GO:0097677
GO:0106226
GO:0120300
GO:0120301
GO:0140033
GO:0140064
GO:0140065
GO:0140066
GO:0140067
GO:0140068
GO:0140069
GO:0140096
GO:0140110
GO:0140297
GO:0140908
GO:1900034
GO:1901796
GO:1904263
GO:2000330
HMNXSV003039205
HMNXSV003052530
Hs.25272.0.A2_3p_a_at
Hs.25272.1.A1_3p_a_at
ILMN_1744665
PH_hs_0023353
PH_hs_0032399
TC22000332.hg
U01877_at
Participates
as a component of
as an input of
as an output of
as a member of
as a candidate of
This entity regulates
Negatively
Other forms of this molecule
p-S,T-EP300 [nucleoplasm]
FOXO4-S-S-EP300 [nucleoplasm]
Foxo4-S-S-EP300 [nucleoplasm]
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
Inferred To
Ep300 [nucleoplasm] (Rattus norvegicus)
Ghost homologue of EP300 [nucleoplasm] (Danio rerio)
Ghost homologue of EP300 [nucleoplasm] (Dictyostelium discoideum)
EP300 [nucleoplasm] (Bos taurus)
EP300 [nucleoplasm] (Caenorhabditis elegans)
EP300 [nucleoplasm] (Canis familiaris)
EP300 [nucleoplasm] (Gallus gallus)
EP300 [nucleoplasm] (Mus musculus)
EP300 [nucleoplasm] (Sus scrofa)
ep300 [nucleoplasm] (Xenopus tropicalis)
nej [nucleoplasm] (Drosophila melanogaster)
Cross References
RefSeq
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
GlyGen
PDB
ZINC - Metabolites
HPA
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (61)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P04637 TP53  20 0.976 22
 UniProt:Q16665 HIF1A  7 0.962 20
 UniProt:P24941 CDK2  5 0.784 7
 UniProt:Q96EB6 SIRT1  1 0.734 4
 UniProt:P27695 APEX1  1 0.724 8
 UniProt:P03255 E1A      0.702 3
 UniProt:P03255-2      0.702 3
 UniProt:Q8WXX7 AUTS2  1 0.677 6
 UniProt:Q6ZUJ4 CC062      0.671 5
 UniProt:Q9QXM1  2 0.66 16
 UniProt:P06790 VE2      0.658 6
 UniProt:Q04206 RELA  7 0.658 4
 UniProt:O15350 TP73  3 0.653 3
 UniProt:P03259 E1A      0.646 3
 UniProt:Q9UBL3 ASH2L  1 0.623 5
 UniProt:P17844 DDX5  4 0.61 4
 UniProt:P03126 VE6      0.602 8
 UniProt:O60934 NBN  3 0.602 5
 UniProt:P20265 POU3F2  1 0.602 3
 UniProt:Q9H2X6 HIPK2  3 0.602 4
 UniProt:P03129 VE7      0.593 14
 UniProt:P35637 FUS  1 0.591 4
 UniProt:Q9NPI1 BRD7  1 0.591 3
 UniProt:P04608 tat  1 0.576 3
 UniProt:Q01844 EWS      0.573 2
 UniProt:P61201 COPS2  2 0.558 2
 UniProt:Q13761 RUNX3  7 0.558 7
 UniProt:P62993 GRB2  1 0.553 2
 UniProt:P11473 VDR  2 0.547 3
 UniProt:P55209 NP1L1      0.544 3
 UniProt:P06422 VE2      0.544 7
 UniProt:Q08369 Gata4  2 0.544 2
 UniProt:Q9Y6Q9 NCOA3  2 0.536 2
 UniProt:P03372 ESR1  10 0.536 2
 UniProt:Q9Y463 DYR1B      0.527 2
 IntAct:EBI-1550784 CDKN1A      0.527 3
 IntAct:EBI-1776214 KLK3      0.527 2
 UniProt:Q12834 CDC20  3 0.527 3
 UniProt:P29279 CTGF  1 0.527 2
 UniProt:Q13627 DYRK1A  1 0.527 2
 UniProt:Q92793 CREBBP  4 0.527 2
 UniProt:P20248 CCNA2  3 0.527 3
 UniProt:P11142 HSPA8  10 0.527 2
 UniProt:O95863 SNAI1  1 0.525 3
 UniProt:K4P3M7 K4P3M7      0.524 4
 UniProt:P56279 TCL1A      0.524 4
 UniProt:Q13309 SKP2  3 0.524 3
 UniProt:Q92831 KAT2B  1 0.524 2
 UniProt:Q99967 CITED2  1 0.508 3
 UniProt:P05549 TFAP2A  1 0.508 7
 UniProt:Q13625 TP53BP2  1 0.499 2
 UniProt:P03070 LT      0.499 2
 UniProt:Q9UL17 TBX21      0.499 5
 UniProt:Q96KQ4 PPP1R13B  1 0.499 2
 UniProt:Q61221  7 0.499 2
 UniProt:Q8WUF5 PPP1R13L  1 0.499 2
 UniProt:Q9UMX0 UBQLN1  1 0.488 2
 UniProt:P06930 VE6      0.462 2
 UniProt:P06428 VE6      0.462 2
 UniProt:Q9P0U4 CXXC1  1 0.462 2
 UniProt:Q12905 ILF2  5 0.462 2
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