FXR1(2-784)-p-BRAF(381-766) fusion [cytosol]

Stable Identifier
R-HSA-6802530
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
23583981 Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

Lu, C, Dooling, DJ, Qaddoumi, I, Parker, M, Ellison, DW, Rusch, M, Easton, J, Miller, CP, Hedlund, E, Vadodaria, B, Downing, JR, Orisme, W, Tatevossian, RG, Wilson, RK, Wang, J, Zhao, D, Sheer, D, Kriwacki, R, Lee, R, Huether, R, Becksfort, J, Shurtleff, S, Wu, G, Boop, FA, Kandoth, C, Chen, X, Ma, J, Boggs, K, Baker, SJ, Gajjar, A, Fulton, RS, Mardis, ER, Fulton, LL, Gilbertson, RJ, Cheng, J, Wei, L, Tang, B, Punchihewa, C, Dalton, JD, Song, G, Mulder, HL, Ochoa, K, Ding, L, Tang, C, Nagahawatte, P, Mullighan, CG, Zhang, J, Li, Y

Nat. Genet. 2013
External Reference Information
External Reference
UniProt:P51114 FXR1
Gene Names
FXR1
Chain
initiator methionine:, chain:2-621
Reference Genes
COSMIC (genes):FXR1 FXR1
dbSNP Gene:8087 FXR1
ENSEMBL:ENSG00000114416 FXR1
Participates
as a component of
Other forms of this molecule
FXR1(2-784)-BRAF(381-766) fusion [cytosol]
Modified Residues
Name
Insertion of residues 381 to 766 at 785 from UniProt:P15056 BRAF
Coordinate
785
Name
O-phospho-L-serine at 446
Coordinate
446
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 599
Coordinate
599
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 602
Coordinate
602
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
astrocytoma DOID:3069 astrocytoma of Cerebrum, Astrocytic tumor, astrocytoma of brain (disorder), astroglioma, astrocytoma, no ICD-O subtype (morphologic abnormality), cerebral astrocytoma
pilocytic astrocytoma DOID:4851 Piloid astrocytoma, grade I Astrocytic tumor
Interactors (10)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P04792 HSBP1  3 0.553 2
 UniProt:P23246 SFPQ  3 0.547 2
 UniProt:O43159 RRP8  1 0.527 2
 UniProt:Q13416 ORC2  1 0.527 2
 UniProt:P07437 TUBB  3 0.508 2
 UniProt:Q674X7 KAZN  1 0.508 2
 UniProt:P04637 TP53  20 0.508 2
 UniProt:Q96CW1 AP2M1  6 0.508 2
 UniProt:P21333 FLNA  3 0.508 2
 UniProt:Q86UR5 RIMS1  1 0.499 2
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