Reactome | LAMA4 [extracellular region]

LAMA4 [extracellular region]

Stable Identifier

R-HSA-2328105

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Laminin alpha-4 chain, LAMA4_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by MET (Homo sapiens)
    - MET promotes cell motility (Homo sapiens)
      - MET activates PTK2 signaling (Homo sapiens)
        
        PTK2 binds activated MET (Homo sapiens)
        
        Integrin alpha2beta1,alpha3:beta1:(collagen,laminin,fibronectin) [plasma membrane] (Homo sapiens)
        
        Collagen, laminin, fibronectin [extracellular region] (Homo sapiens)
        
        Laminins [extracellular region] (Homo sapiens)
        
        Laminin-411 [extracellular region] (Homo sapiens)
        
        LAMA4 [extracellular region] (Homo sapiens)
        
        Laminin-421 [extracellular region] (Homo sapiens)
        
        LAMA4 [extracellular region] (Homo sapiens)
        
        Laminin-423 [extracellular region] (Homo sapiens)
        
        LAMA4 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16363 LAMA4

Gene Names

LAMA4

Chain

signal peptide:1-24, chain:25-1823

Reference Genes

BioGPS Gene:3910 Q163633

COSMIC - genes:LAMA4 LAMA4

CTD Gene:3910 Q163633

dbSNP Gene:3910 LAMA4

ENSEMBL:ENSG00000112769 LAMA4

HGNC:6484 Q163633

KEGG:hsa:3910 Q163633

Monarch:3910 Q163633

NCBI Gene:3910 Q163633

OMIM:600133 Q163633

UCSC:Q16363 Q163633

Reference Transcript

Participates

as a component of

Inferred To

LAMA4 [extracellular region] (Sus scrofa)

Lama4 [extracellular region] (Mus musculus)

Lama4 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_001098679.1, XP_047274726.1, NP_002281.3, NP_001098677.2, XP_005267040.2, NP_001098676.2, NP_001098678.1, XP_016866343.1, XP_005267041.2, XP_047274725.1

ENSEMBL

ENST00000453937, ENSP00000357627, ENSP00000408604, ENST00000455073, ENSP00000398226, ENSG00000112769, ENST00000368638

OpenTargets

ENSG00000112769

GeneCards

LAMA4

HPA

ENSG00000112769-LAMA4

PRO

Q16363

Pharos - Targets

Q16363

GlyGen

Q16363

Orphanet

LAMA4

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.519	2

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