Reactome | ARRB1 [cytosol]

ARRB1 [cytosol]

Stable Identifier

R-RNO-264470

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

P29066

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Deubiquitination (Rattus norvegicus)
    - Ub-specific processing proteases (Rattus norvegicus)
      - USP33 deubiquitinates CCP110,ARRB (Rattus norvegicus)
        
        USP33:CCP110,ARRB1,ARRB2 [cytosol] (Rattus norvegicus)
        
        CCP110,ARRB2,(ARRB1) [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
    - BAR domain proteins recruit dynamin (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
      - CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
    - Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
      - ARBB recruits GPCRs into clathrin-coated pits (Rattus norvegicus)
        
        ARBBs:ARBB-binding GPCRs:clathrin-coated pit [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
      - ARRB bind GPCRs (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
    - Clathrin recruits PIK3C2A (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
    - RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        ARRB:ARRB-binding GPCRs [plasma membrane] (Rattus norvegicus)
        
        ARRB [cytosol] (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
  - trans-Golgi Network Vesicle Budding (Rattus norvegicus)
    - Golgi Associated Vesicle Biogenesis (Rattus norvegicus)
      - Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
      - trans-Golgi Network Derived Vesicle Uncoating (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
    - Lysosome Vesicle Biogenesis (Rattus norvegicus)
      - Vamp And trans-Golgi Network AP-1 Binding Coupled With Cargo Capture On Lysosome Vesicle Destined Golgi Membrane (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)
      - trans-Golgi Network Derived Lysosomal Vesicle Uncoating (Rattus norvegicus)
        
        ARRB1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P29066

Reference Genes

BioGPS Gene:25387

ENSEMBL:ENSRNOG00000030404

KEGG:rno:25387

Monarch:25387

NCBI Gene:25387

UCSC:P29066

Reference Transcript

RefSeq:NM_012910.2

Participates

as an output of

as an input of

as a candidate of

as a component of

F2R:ARRB1 [plasma membrane] (Rattus norvegicus)

as a member of

ARRB [cytosol] (Rattus norvegicus)

Other forms of this molecule

ARRB1 [cytoplasmic vesicle membrane]

ARRB1 [Golgi membrane]

ARRB1 [lysosomal membrane]

ARRB1 [endocytic vesicle membrane]

PolyUb-ARRB1 [cytosol]

Inferred From

ARRB1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_037042.1

PRO

P29066

RGD

2156

PDB

8GP3, 8I0Q, 6KL7, 4JQI, 8I0N, 8JA3, 6U1N, 8J8Z, 8HSV, 8GO8, 8HST

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55085 F2RL1	1	F2RL1(37-397) [plasma membrane] (R-HSA-389418)	0.599	6
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.544	3
UniProt:P11345 Raf1	14	phospho-p-S338,Y340,Y341-RAF1 [cytosol] (R-RNO-5624465) phospho-p-S338-RAF1 [cytosol] (R-RNO-5624469) RAF proto-oncogene serine/threonine-protein kinase [cytosol] (R-RNO-189849) p-S,T-Raf1 [cytosol] (R-RNO-182032) phospho-hyperphosphorylated RAF1 [plasma membrane] (R-RNO-5675193) phospho-p-S621-RAF1 [plasma membrane] (R-RNO-206222) phospho-p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-RNO-5675420) phospho-p-S259,S621-RAF1 [cytosol] (R-RNO-109786) RAF1 [cytosol] (R-RNO-167205) phospho-p-Y-RAF1 [cytosol] (R-RNO-9732747) Raf1 [cytosol] (R-RNO-182075) phospho-p-S621-RAF1 [cytosol] (R-RNO-206028) phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-RNO-5672665) phospho-p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-RNO-5672664)	0.537	5
UniProt:P53667 LIMK1	3	LIMK1 [cytosol] (R-HSA-397785) p-T508-LIMK1 [cytosol] (R-HSA-399816) p-S,T508-LIMK1 [cytosol] (R-HSA-419610)	0.524	2

Cite Us!