Reactome | DAXX H26Tfs*118 [nucleoplasm]

DAXX H26Tfs*118 [nucleoplasm]

Stable Identifier

R-HSA-9673114

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Diseases of Telomere Maintenance (Homo sapiens)
    - Alternative Lengthening of Telomeres (ALT) (Homo sapiens)
      - Defective Inhibition of DNA Recombination at Telomere (Homo sapiens)
        
        Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations (Homo sapiens)
        
        Defective DAXX does not bind ATRX (Homo sapiens)
        
        DAXX Truncation Mutants (N-terminus) [nucleoplasm] (Homo sapiens)
        
        DAXX H26Tfs*118 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UER7 DAXX

Gene Names

DAXX, BING2, DAP6

Chain

chain:1-740

Reference Genes

BioGPS Gene:1616 DAXX

COSMIC - genes:DAXX DAXX

CTD Gene:1616 DAXX

dbSNP Gene:1616 DAXX

ENSEMBL:ENSG00000204209 DAXX

HGNC:2681 DAXX

KEGG:hsa:1616 DAXX

Monarch:1616 DAXX

NCBI Gene:1616 DAXX

OMIM:603186 DAXX

UCSC:Q9UER7 DAXX

Reference Transcript

Participates

as a candidate of

DAXX Truncation Mutants (N-terminus) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

DAXX [nucleoplasm]

DAXX A36Qfs*108 [nucleoplasm]

DAXX K56* [nucleoplasm]

DAXX A103Sfs*40 [nucleoplasm]

DAXX C106* [nucleoplasm]

DAXX E72Nfs*72 [nucleoplasm]

DAXX E104* [nucleoplasm]

DAXX S138* [nucleoplasm]

DAXX C74* [nucleoplasm]

DAXX R48Vfs*93 [nucleoplasm]

DAXX L98Vfs*13 [nucleoplasm]

monoSUMO1-K630,K631-DAXX [nucleoplasm]

Modified Residues

Name

Replacement of residues 26 to 142 by THSPMRPHLGQKPLAPLSLMGPEEAVVRAARNATSWRMRSCSKSSLNFVRCRQQTTLRWSHSSITGSNVPTLCFWPRRSSATSSLGSCLGPGAGQPSSMSTSMSSALFSRPTQPKRS

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
oral cavity cancer	DOID:8618	malignant tumor of lateral floor of mouth (disorder), malignant tumor of anterior floor of mouth (disorder), malignant neoplasm of other sites of floor of mouth, malignant tumor of floor of mouth (disorder), malignant neoplasm of anterior portion of floor of mouth, malignant neoplasm of lateral floor of mouth, malignant neoplasm of floor of mouth, NOS, malignant neoplasm of other sites of floor of mouth (disorder), malignant neoplasm of floor of mouth NOS (disorder), malignant neoplasm of floor of mouth, oral cavity cancer, malignant tumor of the Floor of the Mouth, malignant neoplasm of lateral portion of floor of mouth, malignant neoplasm of floor of mouth

Cross References

RefSeq

NP_001241646.1, NP_001135441.1, NP_001341.1

COSMIC

COSV56467034

OpenTargets

ENSG00000204209

ENSEMBL

ENSG00000206206, ENST00000383194, ENSP00000410772, ENST00000617660, ENST00000616312, ENST00000619421, ENSP00000394108, ENSP00000404376, ENSP00000483517, ENSP00000266000, ENSP00000479172, ENSP00000480448, ENSP00000382014, ENST00000622655, ENST00000455860, ENSG00000227046, ENST00000399344, ENSP00000478810, ENST00000399060, ENST00000612888, ENST00000414083, ENSG00000204209, ENSP00000484830, ENSP00000382281, ENST00000383062, ENSP00000404623, ENSP00000482399, ENSP00000396876, ENSP00000372681, ENSG00000206279, ENST00000613912, ENST00000620164, ENSG00000231617, ENST00000436311, ENST00000433482, ENST00000612868, ENST00000374542, ENSP00000477633, ENST00000266000, ENST00000445009, ENSP00000372539, ENSP00000483394, ENSP00000363668

Mondo

0005515

GeneCards

DAXX

HPA

ENSG00000204209-DAXX

PRO

Q9UER7

Pharos - Targets

Q9UER7

GlyGen

Q9UER7

PDB

2KZS, 4H9R, 4H9Q, 5Y6O, 4H9P, 4H9O, 4H9N, 5Y18, 5GRQ, 2KQS, 4HGA, 5KDM, 2KZU, 4H9S

Interactors (119)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.895	18
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.877	13
UniProt:P46100 ATRX	20	ATRX E288* [nucleoplasm] (R-HSA-9670958) ATRX K329Ifs3 [nucleoplasm] (R-HSA-9672232) ATRX Q176 [nucleoplasm] (R-HSA-9671592) ATRX C268Qfs18 [nucleoplasm] (R-HSA-9672233) ATRX Q177 [nucleoplasm] (R-HSA-9671589) ATRX K330Nfs2 [nucleoplasm] (R-HSA-9672231) ATRX G161 [nucleoplasm] (R-HSA-9671266) ATRX Q176Hfs13 [nucleoplasm] (R-HSA-9671806) ATRX R160Pfs29 [nucleoplasm] (R-HSA-9671801) ATRX K319* [nucleoplasm] (R-HSA-9671669) ATRX W222* [nucleoplasm] (R-HSA-9671670) ATRX E63* [nucleoplasm] (R-HSA-9670961) ATRX S79* [nucleoplasm] (R-HSA-9671244) ATRX H166Mfs4 [nucleoplasm] (R-HSA-9672205) ATRX Y266 [nucleoplasm] (R-HSA-9671624) ATRX L253* [nucleoplasm] (R-HSA-9671688) ATRX W263* [nucleoplasm] (R-HSA-9671685) ATRX Y187* [nucleoplasm] (R-HSA-9671622) ATRX Y204* [nucleoplasm] (R-HSA-9671619) ATRX Q292* [nucleoplasm] (R-HSA-9671581)	0.867	12
UniProt:P84243 H3-3A	20	Me2K5-H3F3A [nucleoplasm] (R-HSA-1214206) H3F3A [nucleoplasm] (R-HSA-212295) Me3K-28-H3F3A [nucleoplasm] (R-HSA-212282) Cit-R3,R9,R18,R27-H3F3A [extracellular region] (R-HSA-9855664) Me3K5-H3F3A [nucleoplasm] (R-HSA-1214216) AcK10-H3F3A [nucleoplasm] (R-HSA-5250654) Me2K-10-H3F3A [nucleoplasm] (R-HSA-427324) p-T12-H3F3A [nucleoplasm] (R-HSA-5625878) p-T12,MeK-H3F3A [nucleoplasm] (R-HSA-5625858) p-T12, Me2K-10-H3F3A [nucleoplasm] (R-HSA-5625800) p-T12,Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625758) Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625747) Me2K5,Me2aR2-H3F3A [nucleoplasm] (R-HSA-8936573) H3F3A [extracellular region] (R-HSA-977567) acK H3F3A [nucleoplasm] (R-HSA-9943919) H3R17me2a [nucleoplasm] (R-HSA-9822613) MeK28-H3-3A [nucleoplasm] (R-HSA-9822942) MeK-H3F3A [nucleoplasm] (R-HSA-427369) Me1K5-H3-3A [nucleoplasm] (R-HSA-9864864) 2xAcK-H3F3A [nucleoplasm] (R-HSA-427504)	0.85	8
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.844	16
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.806	7
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.795	8
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.793	11
UniProt:P29590 PML	5	PML [cytosol] (R-HSA-5624327) PML [nucleoplasm] (R-HSA-1031706) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386)	0.791	6
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) SUMO1 [nucleoplasm] (R-HSA-877304) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382)	0.783	7
UniProt:O43791 SPOP	3	SPOP [cytosol] (R-HSA-9929375) p-S6-SPOP [cytosol] (R-HSA-9929374) SPOP [nucleoplasm] (R-HSA-5635035)	0.757	9
UniProt:P62805 H4C1	20	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) Cit-R4-HIST1H4 [extracellular region] (R-HSA-9855681) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 2xAcK-HIST1H4A [nucleoplasm] (R-HSA-9941607) acK HIST1H4 [nucleoplasm] (R-HSA-9943852) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518)	0.744	7
UniProt:Q9H2P0 ADNP	1	ADNP [nucleoplasm] (R-HSA-9940393)	0.725	6
UniProt:Q7Z6G3-2 NECAB2			0.718	6
UniProt:Q99497 PARK7	7	PolyUb-Misfolded PARK7 [lysosomal lumen] (R-HSA-9659997) PolyUb-Misfolded PARK7 [cytosol] (R-HSA-9641128) Ub-Misfolded PARK7 [cytosol] (R-HSA-9641123) Misfolded PARK7 [cytosol] (R-HSA-9641100) PolyUb-Misfolded PARK7 [late endosome lumen] (R-HSA-9660005) PARK7 [nucleoplasm] (R-HSA-3900141) monoSUMO1-K130-PARK7 [nucleoplasm] (R-HSA-4085351)	0.714	6
UniProt:Q8ND90 PNMA1			0.696	5
UniProt:P03179 MTP			0.693	5
UniProt:P02794 FTH1	5	FTH1 [cytosol] (R-HSA-434212) FTH1 [tertiary granule lumen] (R-HSA-6801508) FTH1 [extracellular region] (R-HSA-2187212) FTH1 [ficolin-1-rich granule lumen] (R-HSA-6801531) FTH1 [endocytic vesicle lumen] (R-HSA-2299670)	0.691	5
UniProt:P25445 FAS	1	FAS [plasma membrane] (R-HSA-66248)	0.674	3
UniProt:Q8IZU0 FAM9B			0.666	4
UniProt:P63279 UBE2I	9	monoSUMO1-K14-UBE2I [nucleoplasm] (R-HSA-4085358) UBE2I [nuclear envelope] (R-HSA-4655408) SUMO3-C93-UBE2I [nucleoplasm] (R-HSA-3730629) UBE2I [nucleoplasm] (R-HSA-912481) SUMO1-C93-UBE2I [nucleoplasm] (R-HSA-3730617) SUMO2-C93-UBE2I [nucleoplasm] (R-HSA-3730619) SUMO1-C93-UBE2I [cytosol] (R-HSA-4656909) UBE2I [cytosol] (R-HSA-4655342) SUMO2-C93-UBE2I [cytosol] (R-HSA-4656944)	0.647	3
UniProt:Q15287 RNPS1	2	RNPS1 [cytosol] (R-HSA-159256) RNPS1 [nucleoplasm] (R-HSA-156778)	0.643	4
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.643	3
UniProt:P79522 PRR3			0.643	4
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.643	3
UniProt:P25446	1	Fas [plasma membrane] (R-MMU-66248)	0.635	4
UniProt:Q9NS23 RASF1			0.628	6
UniProt:P10275 AR	4	AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.625	5
UniProt:P14672 SLC2A4	2	SLC2A4 [cytoplasmic vesicle membrane] (R-HSA-1449565) SLC2A4 [plasma membrane] (R-HSA-70383)	0.625	7
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.618	4
UniProt:Q9NS23-4 RASSF1			0.618	5
UniProt:Q8N726 CDKN2A	12	p14ARF [nucleoplasm] (R-HSA-1629813) p14ARF [cytosol] (R-HSA-9645669) p14ARF [mitochondrial matrix] (R-HSA-9645695) p14ARF R98L;R99S [cytosol] (R-HSA-9645730) p14ARF R82C [cytosol] (R-HSA-9645750) p14ARF R90H [cytosol] (R-HSA-9645755) p14ARF R88Q [cytosol] (R-HSA-9645754) p14ARF R87C [cytosol] (R-HSA-9645759) p14ARF R81G [cytosol] (R-HSA-9645741) p14ARF R98Q [cytosol] (R-HSA-9645757) p14ARF R99C [cytosol] (R-HSA-9645756) p14ARF V22Pfs*46 [cytosol] (R-HSA-9646285)	0.611	8
UniProt:Q02650	1	Pax5 [nucleoplasm] (R-MMU-158583)	0.581	4
UniProt:P15991 HSPB1			0.581	3
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-386-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783067) Ub-6-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783122)	0.573	2
UniProt:O76021 RL1D1			0.564	2
UniProt:Q7Z412 PEX26	2	PEX26 [cytosol] (R-HSA-9603779) PEX26 [peroxisomal membrane] (R-HSA-9033092)	0.556	3
UniProt:A0A6Q8PF08 A0A6Q8PF08			0.556	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.556	3
UniProt:Q9NPF5 DMAP1	1	DMAP1 [nucleoplasm] (R-HSA-212166)	0.556	3
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.556	3
UniProt:Q9P2G9-2 KLHL8			0.556	3
UniProt:Q9Y2J4 AMOTL2	1	AMOTL2 [cytosol] (R-HSA-2028606)	0.556	3
UniProt:Q8NCY6 MSD4			0.556	3
UniProt:P78317 RNF4	2	RNF4 [nucleoplasm] (R-HSA-5684076) RNF4 [cytosol] (R-HSA-975974)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:Q9HCK0 ZBT26			0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q96GN5 CDA7L			0.556	3
UniProt:Q96MT8-3 CEP63			0.556	3
UniProt:Q8WVF5 KCTD4			0.556	3
UniProt:Q6NXT2 H3C			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	15
UniProt:Q4G0R1 Q4G0R1			0.556	3
UniProt:Q96IK5 GMCL1			0.556	3
UniProt:Q495M9 USH1G	1	USH1G [cytosol] (R-HSA-9658869)	0.556	3
UniProt:Q86WH2 RASF3			0.556	3
UniProt:Q4V328 GRAP1			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q9H257 CARD9	3	CARD9 [cytosol] (R-HSA-561194) p-T231-CARD9 [plasma membrane] (R-HSA-5607623) CARD9 [plasma membrane] (R-HSA-5607662)	0.556	3
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.556	5
UniProt:Q8TD10 MIPO1			0.556	3
UniProt:Q96AQ6 PBIP1			0.556	3
UniProt:Q8N680 ZBTB2			0.556	3
UniProt:Q9Y2D8 ADIP			0.556	3
UniProt:O95995 DRC4	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	5
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.556	3
UniProt:Q9UJW9 SRTD3			0.556	3
UniProt:Q92870-2 Q928702			0.556	3
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) p-STAT3 [cytosol] (R-HSA-8982823) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-S727-STAT3 [cytosol] (R-HSA-198705) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.556	4
UniProt:Q9UHC7 MKRN1	2	MKRN1 [cytosol] (R-HSA-976042) p-S109-MKRN1 [cytosol] (R-HSA-8948758)	0.556	3
UniProt:Q96KE9 BTBD6	1	BTBD6 [cytosol] (R-HSA-8863208)	0.553	2
UniProt:O43918 AIRE			0.543	5
UniProt:Q9NQB0 TCF7L2	4	TCF7L2 [nucleoplasm] (R-HSA-201923) pT201,T212-TCF7L2 [nucleoplasm] (R-HSA-4411392) TCF7L2 R397W [nucleoplasm] (R-HSA-5339696) TCF7L2 K485fs*25 [nucleoplasm] (R-HSA-5334040)	0.543	5
UniProt:Q8TBK6 ZCH10			0.527	3
UniProt:Q8N9T8 KRI1			0.527	4
UniProt:O95503 CBX6	1	CBX6 [nucleoplasm] (R-HSA-3229071)	0.527	3
UniProt:P35052 GPC1	20	HS(4)-GPC1 [plasma membrane] (R-HSA-2076668) HS(6)-GPC1 [plasma membrane] (R-HSA-2076629) HS(2)-GPC1 [plasma membrane] (R-HSA-2076632) HS(1)-GPC1 [plasma membrane] (R-HSA-2076645) HS(3)-GPC1 [plasma membrane] (R-HSA-2076636) HS(5)-GPC1 [plasma membrane] (R-HSA-2076648) GPC1 [plasma membrane] (R-HSA-425952) GPC1 [Golgi lumen] (R-HSA-2054106) XylS-GPC1 [Golgi lumen] (R-HSA-2064041) Gal-Xyl-GPC1 [Golgi lumen] (R-HSA-2064076) Gal-Gal-Xyl-GPC1 [Golgi lumen] (R-HSA-2064144) GlcA-Gal-Gal-Xyl-GPC1 [Golgi lumen] (R-HSA-2064189) Heparan-GPC1 [Golgi lumen] (R-HSA-2076567) Heparan(1)-GPC1 [Golgi lumen] (R-HSA-2076476) Heparan(2)-GPC1 [Golgi lumen] (R-HSA-2076501) Heparan(3)-GPC1 [Golgi lumen] (R-HSA-2076503) Heparan(4)-GPC1 [Golgi lumen] (R-HSA-2076605) HS(1)-GPC1 [Golgi lumen] (R-HSA-2076424) HS(2)-GPC1 [Golgi lumen] (R-HSA-2076296) HS(3)-GPC1 [Golgi lumen] (R-HSA-2076340)	0.527	2
UniProt:P39019 RPS19	2	RPS19 [cytosol] (R-HSA-72343) RPS19 [nucleoplasm] (R-HSA-6798710)	0.527	3
UniProt:O75182 SIN3B	1	SIN3B [nucleoplasm] (R-HSA-3006450)	0.527	4
UniProt:P78316 NOP14	1	NOP14 [nucleoplasm] (R-HSA-6790710)	0.527	2
UniProt:O15417 TNC18			0.527	4
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.527	2
UniProt:Q6ZN17 LN28B			0.527	3
UniProt:Q9H0E3 SAP130	1	SAP130 [nucleoplasm] (R-HSA-3006732)	0.527	3
UniProt:P19784 CSNK2A2	2	CSNK2A2 [cytosol] (R-HSA-201721) CSNK2A2 [nucleoplasm] (R-HSA-6805065)	0.527	2
UniProt:O15479 MAGB2			0.527	2
UniProt:Q7Z4V5 HDGR2			0.527	2
UniProt:Q9UL40 ZN346			0.527	2
UniProt:P84098 RPL19	1	RPL19 [cytosol] (R-HSA-72424)	0.527	3
UniProt:P03244 E1B55			0.527	4
UniProt:Q96JM3 CHAP1			0.527	2
UniProt:Q9UIG0 BAZ1B	1	BAZ1B [nucleoplasm] (R-HSA-417153)	0.527	3
UniProt:Q9BVI4 NOC4L	1	NOC4L [nucleoplasm] (R-HSA-6790616)	0.527	2
UniProt:O60264 SMARCA5	1	SMARCA5 [nucleoplasm] (R-HSA-417140)	0.527	2
UniProt:Q96HA7 TONSL			0.527	3
UniProt:Q96T58 SPEN	1	SPEN [cytosol] (R-HSA-9715142)	0.527	3
UniProt:Q9Y3E7 CHMP3	2	CHMP3 [cytosol] (R-HSA-917722) CHMP3 [endosome membrane] (R-HSA-9631191)	0.527	3
UniProt:Q9UGY1 NOL12	1	NOL12 [nucleoplasm] (R-HSA-6791195)	0.527	2
UniProt:P23396 RPS3	2	RPS3 [cytosol] (R-HSA-72369) RPS3 [nucleoplasm] (R-HSA-6798714)	0.527	2
UniProt:Q9UQ35 SRRM2	1	SRRM2 [nucleoplasm] (R-HSA-8865888)	0.527	3
UniProt:Q7Z3K3 POGZ			0.527	4
UniProt:Q9UPS6 SETD1B	1	SETD1B [nucleoplasm] (R-HSA-5244714)	0.527	2
UniProt:Q13601 KRR1	1	KRR1 [nucleoplasm] (R-HSA-6790611)	0.527	3
UniProt:P18827 SDC1	20	HS(4)-SDC1 [plasma membrane] (R-HSA-2076693) HS(6)-SDC1 [plasma membrane] (R-HSA-2076652) HS(2)-SDC1 [plasma membrane] (R-HSA-2076666) HS(1)-SDC1 [plasma membrane] (R-HSA-2076672) HS(3)-SDC1 [plasma membrane] (R-HSA-2076691) HS(5)-SDC1 [plasma membrane] (R-HSA-2076626) SDC1 [plasma membrane] (R-HSA-174758) SDC1 [Golgi lumen] (R-HSA-2054105) XylS-SDC1 [Golgi lumen] (R-HSA-2064146) Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064148) Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064247) GlcA-Gal-Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064082) Heparan-SDC1 [Golgi lumen] (R-HSA-2076561) Heparan(1)-SDC1 [Golgi lumen] (R-HSA-2076349) Heparan(2)-SDC1 [Golgi lumen] (R-HSA-2076558) Heparan(3)-SDC1 [Golgi lumen] (R-HSA-2076314) Heparan(4)-SDC1 [Golgi lumen] (R-HSA-2076339) HS(1)-SDC1 [Golgi lumen] (R-HSA-2076321) HS(2)-SDC1 [Golgi lumen] (R-HSA-2076309) HS(3)-SDC1 [Golgi lumen] (R-HSA-2076444)	0.527	2
UniProt:Q9P0U4 CXXC1	1	CXXC1 [nucleoplasm] (R-HSA-535610)	0.527	3
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.524	2
UniProt:Q9P243 ZFAT			0.524	5
UniProt:Q9BZ95 NSD3	1	WHSC1L1 [nucleoplasm] (R-HSA-1183230)	0.508	2
UniProt:P37173 TGFBR2	9	TGFBR2 [plasma membrane] (R-HSA-170842) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 Y470D [plasma membrane] (R-HSA-3640905)	0.508	2
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.499	2
IntAct:EBI-70800930 BCR-ABL1 E13A2 FUSION PROTEIN			0.499	6
UniProt:P35659 DEK	1	DEK [nucleoplasm] (R-HSA-5250643)	0.499	2
UniProt:Q92793 CREBBP	4	CREBBP [nucleoplasm] (R-HSA-193545) CREBBP [cytosol] (R-HSA-9756493) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.499	2
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.483	2
UniProt:P03243 E1B55			0.463	4

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