Reactome | RFWD2 [nucleoplasm]

RFWD2 [nucleoplasm]

Stable Identifier

R-HSA-349454

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

COP1

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G1/S DNA Damage Checkpoints (Homo sapiens)
    - p53-Dependent G1/S DNA damage checkpoint (Homo sapiens)
      - p53-Dependent G1 DNA Damage Response (Homo sapiens)
        
        Stabilization of p53 (Homo sapiens)
        
        Autodegradation of the E3 ubiquitin ligase COP1 (Homo sapiens)
        
        Phosphorylation of COP1 at Ser-387 by ATM (Homo sapiens)
        
        RFWD2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8NHY2 RFWD2

Gene Names

RFWD2, COP1, RNF200

Chain

chain:1-731

Reference Genes

BioGPS Gene:64326 COP1

COSMIC (genes):COP1 RFWD2

CTD Gene:64326 COP1

dbSNP Gene:64326 COP1

ENSEMBL:ENSG00000143207 RFWD2

HGNC:17440 COP1

KEGG:hsa:64326 COP1

Monarch:64326 COP1

NCBI Gene:64326 COP1

OMIM:608067 COP1

UCSC:Q8NHY2 COP1

Reference Transcript

Participates

as a member of

DCAF protein [nucleoplasm] (Homo sapiens)

as an input of

Phosphorylation of COP1 at Ser-387 by ATM (Homo sapiens)

Other forms of this molecule

p-S387-RFWD2 [nucleoplasm]

p-S387-RFWD2 [cytosol]

Inferred To

par-2 [nucleoplasm] (Caenorhabditis elegans)

COP1 [nucleoplasm] (Bos taurus)

COP1 [nucleoplasm] (Canis familiaris)

COP1 [nucleoplasm] (Sus scrofa)

RFWD2 [nucleoplasm] (Dictyostelium discoideum)

RFWD2 [nucleoplasm] (Gallus gallus)

cop1 [nucleoplasm] (Danio rerio)

cop1 [nucleoplasm] (Xenopus tropicalis)

Cop1 [nucleoplasm] (Mus musculus)

Cop1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001001740.1, NP_001273573.1, NP_071902.2

OpenTargets

ENSG00000143207

ENSEMBL

ENST00000308769, ENSP00000310943, ENSP00000356641, ENSP00000433517, ENST00000474194, ENSG00000143207, ENST00000367669

IntEnz

2.3.2.27

HPA

ENSG00000143207-COP1

GeneCards

COP1

PRO

Q8NHY2

Pharos - Targets

Q8NHY2

GlyGen

Q8NHY2

PDB

5HQG, 5IGQ

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.725	6
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.718	6
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.717	5
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.708	5
UniProt:Q92519 TRIB2			0.623	4
UniProt:P41161 ETV5			0.604	4
UniProt:P15036 ETS2	2	p-T72-ETS2 [nucleoplasm] (R-HSA-3132735) ETS2 [nucleoplasm] (R-HSA-1629811)	0.564	2
UniProt:P50549 ETV1			0.564	4
UniProt:Q96RU7 TRIB3	3	TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [cytosol] (R-HSA-162411) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.527	2
UniProt:Q96RU8 TRIB1	1	TRIB1 [cytosol] (R-HSA-9621338)	0.527	3
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.527	2
UniProt:Q8N2I9 STK40			0.527	4
UniProt:P18850 ATF6	7	ATF6 [endoplasmic reticulum membrane] (R-HSA-381222) ATF6 [Golgi membrane] (R-HSA-381000) ATF6(1-419) [Golgi membrane] (R-HSA-420815) ATF6(1-380) [cytosol] (R-HSA-381075) ATF6(380-419) [Golgi membrane] (R-HSA-420817) ATF6(420-670) [Golgi membrane] (R-HSA-420814) ATF6(1-380) [nucleoplasm] (R-HSA-381211)	0.527	2
UniProt:P15408 FOSL2			0.527	3
UniProt:Q7L5N1 COPS6	2	COPS6 [nucleoplasm] (R-HSA-5697026) COPS6 [cytosol] (R-HSA-416961)	0.525	3
UniProt:P14921-1 ETS1			0.524	3

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