Reactome | PLOD3 [endoplasmic reticulum membrane]

PLOD3 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-1981135

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3, PLOD3_HUMAN, Lysyl hydroxylase 3

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O60568 PLOD3

Gene Names

PLOD3

Chain

signal peptide:1-24, chain:25-738

Reference Genes

BioGPS Gene:8985 PLOD3

COSMIC (genes):PLOD3 PLOD3

CTD Gene:8985 PLOD3

dbSNP Gene:8985 PLOD3

ENSEMBL:ENSG00000106397 PLOD3

HGNC:9083 PLOD3

KEGG:hsa:8985 PLOD3

Monarch:8985 PLOD3

NCBI Gene:8985 PLOD3

OMIM:603066 PLOD3

UCSC:O60568 PLOD3

Reference Transcript

RefSeq:NM_001084.4 PLOD3

Other Identifiers

11715786_at

11747563_a_at

11749505_a_at

11749506_x_at

11758519_s_at

17060857

202185_PM_at

202185_at

3064542

3064543

3064545

3064547

3064548

3064549

3064550

3064551

3064552

3064553

3064554

3064555

3064556

3064557

3064558

3064559

3064560

3064561

3064562

3064563

3064564

3064565

3064566

3064567

3064568

3064569

3064570

3064571

3064572

3064573

39801_at

8141688

8985

A_23_P168788

GE54960

GO:0001701

GO:0001886

GO:0003013

GO:0003824

GO:0005506

GO:0005515

GO:0005576

GO:0005615

GO:0005783

GO:0005788

GO:0005789

GO:0005791

GO:0005794

GO:0005802

GO:0006486

GO:0006493

GO:0006520

GO:0006575

GO:0008104

GO:0008475

GO:0016020

GO:0016491

GO:0016705

GO:0016740

GO:0016757

GO:0017185

GO:0021915

GO:0030198

GO:0030199

GO:0030312

GO:0031012

GO:0031418

GO:0032963

GO:0033823

GO:0036094

GO:0042311

GO:0043226

GO:0046872

GO:0046947

GO:0048730

GO:0048856

GO:0050211

GO:0051213

GO:0060425

GO:0062023

GO:0070062

GO:0070831

GO:0140096

HMNXSV003054741

ILMN_1774836

PH_hs_0009226

TC07001687.hg

g4505890_3p_at

Participates

as a component of

PLOD3:Fe2+ dimer [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

plod3 [endoplasmic reticulum membrane] (Danio rerio)

plod3 [endoplasmic reticulum membrane] (Xenopus tropicalis)

PLOD3 [endoplasmic reticulum membrane] (Bos taurus)

PLOD3 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

PLOD3 [endoplasmic reticulum membrane] (Canis familiaris)

PLOD3 [endoplasmic reticulum membrane] (Drosophila melanogaster)

PLOD3 [endoplasmic reticulum membrane] (Mus musculus)

PLOD3 [endoplasmic reticulum membrane] (Rattus norvegicus)

PLOD3 [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

ENSEMBL

ENSG00000106397, ENST00000223127, ENSP00000223127

OpenTargets

ENSG00000106397

IntEnz

2.4.1.66, 1.14.11.4

GeneCards

PLOD3

HPA

ENSG00000106397-PLOD3

PRO

O60568

Pharos - Targets

O60568

GlyGen

O60568

Orphanet

PLOD3

HMDB Protein

HMDBP00462

PDB

6FXK, 6TEC, 6TEZ, 6TEU, 8ONE, 6FXT, 6WFV, 6FXX, 6TE3, 6TES, 6FXR, 6FXM, 6FXY, 6TEX

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96KQ7 EHMT2	1	EHMT2 [nucleoplasm] (R-HSA-212151)	0.831	8
UniProt:Q96QF0 RAB3IP	1	RAB3IP [cytosol] (R-HSA-5617610)	0.666	4
UniProt:Q9UMD9 COL17A1	20	GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173102) GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173084) 3x4Hyp-GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173190) 3x4Hyp-3Hyp-GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173237) 3x4Hyp-GalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173184) 3x4Hyp-3Hyp-GlcGalHyl-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2173264) 3x4Hyp-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2172934) 3x4Hyp-3Hyp-COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2172989) COL17A1(1-1497) [plasma membrane] (R-HSA-445994) COL17A1(1-1497) [endoplasmic reticulum lumen] (R-HSA-2172232) GlcGalHyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192833) GalHyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192832) 3x4Hyp-GalHyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192834) 3x4Hyp-3Hyp-GlcGalHyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192837) 3x4Hyp-COL17A1(1-1497) [plasma membrane] (R-HSA-2192836) 3x4Hyp-3Hyp-5Hyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192839) 3x4Hyp-5Hyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192841) 3x4Hyp-GlcGalHyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192840) 3x4Hyp-3Hyp-COL17A1(1-1497) [plasma membrane] (R-HSA-2192843) 5Hyl-COL17A1(1-1497) [plasma membrane] (R-HSA-2192842)	0.556	3
UniProt:Q9UHH9 IP6K2	1	IP6K2 [nucleoplasm] (R-HSA-1015687)	0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	2