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p-T2055-NUMA1 [nucleoplasm]
Stable Identifier
R-HSA-380473
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
phosphorylated NuMA
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prophase (Homo sapiens)
CCNB1:p-T160-CDK1 phosphorylates NUMA1 (Homo sapiens)
p-T2055-NUMA1 homodimer [nucleoplasm] (Homo sapiens)
p-T2055-NUMA1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14980 NUMA1
Gene Names
NUMA1, NMP22, NUMA
Chain
chain:1-2115
Reference Genes
BioGPS Gene:4926 NUMA1
COSMIC (genes):NUMA1 NUMA1
CTD Gene:4926 NUMA1
dbSNP Gene:4926 NUMA1
ENSEMBL:ENSG00000137497 NUMA1
HGNC:8059 NUMA1
KEGG:hsa:4926 NUMA1
Monarch:4926 NUMA1
NCBI Gene:4926 NUMA1
OMIM:164009 NUMA1
UCSC:Q14980 NUMA1
Reference Transcript
RefSeq:XM_011545066.1 NUMA1
RefSeq:XM_017017830.1 NUMA1
RefSeq:XM_006718564.1 NUMA1
RefSeq:NM_001286561.1 NUMA1
RefSeq:XM_017017831.1 NUMA1
RefSeq:NM_006185.3 NUMA1
Other Identifiers
11744332_a_at
11762593_x_at
1554663_PM_a_at
1554663_a_at
16741587
200747_PM_s_at
200747_s_at
214250_PM_at
214250_at
214251_PM_s_at
214251_s_at
329_s_at
3380903
3380904
3380905
3380906
3380907
3380908
3380909
3380910
3380911
3380912
3380913
3380914
3380915
3380917
3380918
3380919
3380920
3380921
3380922
3380924
3380925
3380926
3380927
3380928
3380929
3380930
3380931
3380932
3380933
3380934
3380935
3380936
3380937
3380938
3380939
3380940
3380941
3380942
3380943
3380944
3380945
3380946
3380947
3380948
3380949
3380950
3380951
3380953
3380954
3380955
3380956
3380958
3380959
3380960
3380961
3380968
3380969
3380970
3380971
3380972
3380973
3380975
3380976
33822_at
4926
7950086
A_23_P162120
GE81605
GO:0000132
GO:0000922
GO:0001578
GO:0005198
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005874
GO:0005876
GO:0005886
GO:0005938
GO:0006997
GO:0007010
GO:0007059
GO:0008017
GO:0008092
GO:0008289
GO:0015631
GO:0016328
GO:0016363
GO:0019904
GO:0022414
GO:0030425
GO:0030513
GO:0030953
GO:0031116
GO:0031616
GO:0032388
GO:0032991
GO:0035091
GO:0035371
GO:0036449
GO:0043025
GO:0043226
GO:0043227
GO:0043229
GO:0044877
GO:0045618
GO:0051010
GO:0051011
GO:0051301
GO:0051321
GO:0051798
GO:0051984
GO:0055028
GO:0055048
GO:0060236
GO:0061673
GO:0070062
GO:0070840
GO:0072686
GO:0090235
GO:0097427
GO:0097431
GO:0097575
GO:0097718
GO:0099738
GO:1902365
GO:1902846
GO:1904778
GO:1905720
GO:1905820
GO:1905832
GO:1990023
HMNXSV003045036
Hs.301512.2.S1_3p_at
Hs2.301512.3.S1_3p_a_at
ILMN_1757085
ILMN_2160005
PH_hs_0023837
TC11002049.hg
g5453819_3p_a_at
Participates
as a component of
p-T2055-NUMA1 homodimer [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-NUMA1 [cytosol]
NUMA1 [nucleoplasm]
Inferred To
phospho-p-T2055-NUMA1 [nucleoplasm]
(Gallus gallus)
phospho-Numa1 [nucleoplasm]
(Mus musculus)
phospho-Numa1 [nucleoplasm]
(Rattus norvegicus)
phospho-NUMA1 [nucleoplasm]
(Bos taurus)
phospho-NUMA1 [nucleoplasm]
(Canis familiaris)
phospho-NUMA1 [nucleoplasm]
(Sus scrofa)
phospho-numa1 [nucleoplasm]
(Xenopus tropicalis)
phospho-mud [nucleoplasm]
(Drosophila melanogaster)
Modified Residues
Name
O-phospho-L-threonine at 2055
Coordinate
2055
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_006718627.1
,
XP_016873320.1
,
NP_001273490.1
,
XP_011543368.1
,
XP_016873319.1
,
NP_006176.2
OpenTargets
ENSG00000137497
ENSEMBL
ENST00000393695
,
ENSP00000351851
,
ENSP00000478624
,
ENSP00000260051
,
ENSP00000377298
,
ENST00000351960
,
ENSP00000480172
,
ENST00000358965
,
ENST00000613205
,
ENST00000620566
HPA
ENSG00000137497-NUMA1
PRO
Q14980
Pharos - Targets
Q14980
Orphanet
NUMA1
GlyGen
Q14980
PDB
6QJA
,
6HC2
,
3RO2
,
5GXW
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UIL1 SCOC
1
SCOC [cytosol]
(R-HSA-6813911)
0.527
3
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.462
2
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