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p-S857 NCOA3 [nucleoplasm]
Stable Identifier
R-HSA-5687005
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nuclear receptor coactivator 3, NCOA3_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
p-S MAPK6 phosphorylates NCOA3 (Homo sapiens)
p-S857 NCOA3 [nucleoplasm] (Homo sapiens)
p-S857 NCOA3 binds ETV4 (Homo sapiens)
p-S857 NCOA3 [nucleoplasm] (Homo sapiens)
p-S857 NCOA3:ETV4 [nucleoplasm] (Homo sapiens)
p-S857 NCOA3 [nucleoplasm] (Homo sapiens)
p-S857 NCOA3:ETV4 bind MMP2 and MMP10 promoter (Homo sapiens)
p-S857 NCOA3:ETV4 [nucleoplasm] (Homo sapiens)
p-S857 NCOA3 [nucleoplasm] (Homo sapiens)
p-S857 NOCA3:ETV4:MMP2,10 genes [nucleoplasm] (Homo sapiens)
p-S857 NCOA3:ETV4 [nucleoplasm] (Homo sapiens)
p-S857 NCOA3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y6Q9 NCOA3
Gene Names
NCOA3, AIB1, BHLHE42, RAC3, TRAM1
Chain
initiator methionine:, chain:2-1424
Reference Genes
COSMIC (genes):NCOA3 NCOA3
COSMIC (genes):RAC3 NCOA3
COSMIC (genes):TRAM1 NCOA3
dbSNP Gene:8202 NCOA3
ENSEMBL:ENSG00000124151 NCOA3
Participates
as an input of
p-S857 NCOA3 binds ETV4 (Homo sapiens)
as a component of
p-S857 NCOA3:ETV4 [nucleoplasm] (Homo sapiens)
as an output of
p-S MAPK6 phosphorylates NCOA3 (Homo sapiens)
Other forms of this molecule
NCOA3 [nucleoplasm]
Inferred To
phospho-Ncoa3 [nucleoplasm]
(Mus musculus)
phospho-Ncoa3 [nucleoplasm]
(Rattus norvegicus)
phospho-p-S857 NCOA3 [nucleoplasm]
(Gallus gallus)
phospho-tai [nucleoplasm]
(Drosophila melanogaster)
phospho-NCOA3 [nucleoplasm]
(Bos taurus)
phospho-NCOA3 [nucleoplasm]
(Canis familiaris)
phospho-NCOA3 [nucleoplasm]
(Sus scrofa)
phospho-ncoa3 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 857
Coordinate
857
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.688
4
UniProt:O43791 SPOP
1
SPOP [nucleoplasm]
(R-HSA-5635035)
0.632
6
UniProt:Q86X55 CARM1
1
CARM1 [nucleoplasm]
(R-HSA-400139)
0.623
13
UniProt:P61289 PSME3
1
PSME3 [cytosol]
(R-HSA-68816)
0.602
5
UniProt:P28065 PSMB9
3
pro-PSMB9 [cytosol]
(R-HSA-9908136)
PSMB9 [cytosol]
(R-HSA-68765)
PSMB9(1-20) [cytosol]
(R-HSA-9908132)
0.581
3
UniProt:P10276 RARA
3
RARA [nucleoplasm]
(R-HSA-446164)
polySUMO2-K166,K171,K399-RARA [nucleoplasm]
(R-HSA-4341042)
SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]
(R-HSA-5334830)
0.564
2
ChEBI:90954 MCB-613
0.558
2
UniProt:Q8VIM5-1 MYOCD
0.544
5
UniProt:Q09472 EP300
5
EP300 [nucleoplasm]
(R-HSA-381325)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
monoSUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
0.536
2
UniProt:Q92793 CREBBP
4
CREBBP [nucleoplasm]
(R-HSA-193545)
CREBBP [cytosol]
(R-HSA-9756493)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
0.527
12
UniProt:Q6PL18 ATAD2
1
ATAD2 [nucleoplasm]
(R-HSA-8937250)
0.524
2
UniProt:P48281
2
polySUMO2-VDR [nucleoplasm]
(R-MMU-4546376)
VDR [nucleoplasm]
(R-MMU-375512)
0.508
2
UniProt:P51157 RAB28
0.508
2
UniProt:P10275 AR
4
AR [cytosol]
(R-HSA-5618082)
AR [nucleoplasm]
(R-HSA-446174)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
0.483
3
UniProt:Q92731 ESR2
5
ESR2 [cytosol]
(R-HSA-9020970)
ESR2 [nucleoplasm]
(R-HSA-446165)
Me-PalmS-ESR2 [plasma membrane]
(R-HSA-9637787)
PalmS-ESR2 [plasma membrane]
(R-HSA-9021059)
PalmS-ESR2 [cytosol]
(R-HSA-9020979)
0.462
2
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