Reactome | apoTF [endosome membrane]

apoTF [endosome membrane]

Stable Identifier

R-HSA-917974

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

Serotransferrin

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P02787 TF

Gene Names

TF, PRO1400

Chain

signal peptide:1-19, chain:20-698

Reference Genes

BioGPS Gene:7018 TF

COSMIC (genes):TF TF

CTD Gene:7018 TF

dbSNP Gene:7018 TF

ENSEMBL:ENSG00000091513 TF

HGNC:11740 TF

KEGG:hsa:7018 TF

Monarch:7018 TF

NCBI Gene:7018 TF

OMIM:190000 TF

UCSC:P02787 TF

Reference Transcript

RefSeq:NM_001063.3 TF

Other Identifiers

11719658_a_at

11751529_a_at

11756783_a_at

11762218_at

16945870

16945907

203400_PM_s_at

203400_s_at

214063_PM_s_at

214063_s_at

214064_PM_at

214064_at

220109_PM_at

220109_at

2555254

2643235

2643236

2643237

2643240

2643241

2643243

2643244

2643245

2643246

2643247

2643248

2643249

2643250

2643251

2643252

2643253

2643254

2643255

2643257

2643264

2643265

2643266

2643267

2643268

2643271

2643273

2643274

2643275

2643277

2643278

2643279

2643280

2643281

2643282

2643283

2643284

2643285

2643286

2643287

2643288

2643289

2643290

2643291

2643292

2643293

2643294

2643313

2643314

2643315

2643317

2643319

2643321

2643323

2643325

2643326

2643327

2643328

2643329

2643330

2643331

2643332

32538_at

55329_at

7018

8082797

8082816

A_14_P126348

A_14_P129777

A_14_P202351

A_23_P212500

A_23_P212508

A_23_P69368

A_23_P69372

GE58556

GE58831

GO:0002376

GO:0005515

GO:0005576

GO:0005615

GO:0005768

GO:0005769

GO:0005770

GO:0005788

GO:0005886

GO:0005905

GO:0006355

GO:0006826

GO:0006879

GO:0007015

GO:0008198

GO:0008199

GO:0009617

GO:0009925

GO:0009986

GO:0010008

GO:0016020

GO:0016324

GO:0019731

GO:0019899

GO:0030139

GO:0030154

GO:0030316

GO:0030669

GO:0031410

GO:0031647

GO:0031982

GO:0032436

GO:0034756

GO:0034774

GO:0034986

GO:0042327

GO:0043226

GO:0044325

GO:0045178

GO:0045780

GO:0045893

GO:0046872

GO:0048260

GO:0048471

GO:0055037

GO:0060586

GO:0070062

GO:0070371

GO:0071281

GO:0072562

GO:0098542

GO:0140104

GO:1990459

GO:1990712

GO:2000147

HMNXSV003052276

Hs.284176.3.A1_3p_at

ILMN_1768425

PH_hs_0025298

S95936_at

g4557870_3p_s_at

g7662634_3p_at

Participates

as a component of

Other forms of this molecule

TF [endoplasmic reticulum lumen]

p-TF [endoplasmic reticulum lumen]

apoTF [extracellular region]

TF [secretory granule lumen]

apoTF [clathrin-coated endocytic vesicle membrane]

Inferred To

TF [endosome membrane] (Bos taurus)

TF [endosome membrane] (Sus scrofa)

apoTF [endosome membrane] (Gallus gallus)

apoTF [endosome membrane] (Mus musculus)

apoTF [endosome membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001054.1

OpenTargets

ENSG00000091513

ENSEMBL

ENSP00000385834, ENST00000402696

HPA

ENSG00000091513-TF

ZINC - Substances

TRFE_HUMAN

ZINC target

P02787

PRO

P02787

Pharos - Targets

P02787

GlyGen

P02787

Orphanet

HMDB Protein

HMDBP02076

PDB

1RYO, 1D3K, 3QYT, 5H52, 1A8E, 6SOY, 2HAU, 2HAV, 1JQF, 1DTG, 5X5P, 1SUV, 4H0W, 3S9N, 5WTD, 4X1D, 3VE1, 1OQH, 6D03, 6D04, 1N7X, 3FGS, 6CTC, 2O7U, 7FFM, 3SKP, 5Y6K, 1B3E, 1A8F, 3V8X, 3V83, 6JAS, 1FQF, 7Q1L, 1FQE, 6SOZ, 1D4N, 1BTJ, 8BRC, 3S9L, 3S9M, 1BP5, 1OQG, 4X1B, 6D05, 6UJ6, 1N7W, 3V89, 7FFU, 2O84, 5DYH, 1N84

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02786 TFRC	5	TFRC(1-760) [plasma membrane] (R-HSA-917983) TFRC(1-760) [endosome membrane] (R-HSA-8961829) TFRC(1-760) [cytoplasmic vesicle membrane] (R-HSA-434196) TFRC(1-760) [Golgi membrane] (R-HSA-434330) TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869124)	0.852	7
UniProt:A5K736 A5K736			0.733	9
UniProt:Q9K0U9 TBPA			0.632	4
UniProt:P01350 GAST	1	GAST(76-92) [extracellular region] (R-HSA-870266)	0.618	5
UniProt:Q09057 TBPB1			0.618	3
UniProt:Q9K0V0 TBPB			0.558	2
UniProt:O15173 PGRMC2	4	PGRMC2 [nuclear envelope] (R-HSA-9707674) PGRMC2 [nucleoplasm] (R-HSA-9707859) PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.556	3
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.556	3
UniProt:P08034 GJB1	2	GJB1 [endoplasmic reticulum membrane] (R-HSA-190656) GJB1 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190636)	0.556	3
UniProt:A8MZ59 LEUTX	1	LEUTX [nucleoplasm] (R-HSA-9817277)	0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:O00501 CLDN5	2	CLDN5 [cell junction] (R-HSA-421264) CLDN5 [plasma membrane] (R-HSA-419991)	0.556	3
UniProt:O43278-2 SPINT1			0.556	3
UniProt:Q8N9I0 SYT2	3	SYT2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869116) SYT2 [plasma membrane] (R-HSA-168795) SYT2 [synaptic vesicle membrane] (R-HSA-194786)	0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
UniProt:Q7Z7G2 CPLX4			0.556	3
UniProt:Q96TC7 RMD3			0.556	3
UniProt:Q4KMG9 TM52B			0.556	3
UniProt:Q99523 SORT1	2	SORT1 [Golgi membrane] (R-HSA-434332) SORT1 [cytoplasmic vesicle membrane] (R-HSA-434221)	0.556	3
UniProt:Q8TED1 GPX8	1	GPX8 [endoplasmic reticulum lumen] (R-HSA-3341303)	0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.556	3
UniProt:O15529 GPR42			0.556	3
UniProt:O43315 AQP9	1	AQP9 [plasma membrane] (R-HSA-431761)	0.556	3
UniProt:Q96KR6 F210B			0.556	3
UniProt:Q9BXS9-3 SLC26A6			0.556	3
UniProt:Q16659 MAPK6 gene	6	p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) MAPK6 [nucleoplasm] (R-HSA-5692686) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) p-S189 MAPK6 [cytosol] (R-HSA-5687019) MAPK6 [cytosol] (R-HSA-5686979) ub-MAPK6 [cytosol] (R-HSA-5687000)	0.527	2
UniProt:Q9NQZ2 UTP3	1	UTP3 [nucleoplasm] (R-HSA-6790637)	0.527	2
UniProt:O15232 MATN3	3	MATN3 [extracellular region] (R-HSA-2426297) p-MATN3 [endoplasmic reticulum lumen] (R-HSA-8957026) MATN3 [endoplasmic reticulum lumen] (R-HSA-8956719)	0.527	2
UniProt:Q9H8H2 DDX31			0.527	2
UniProt:Q9H788 SH24A			0.527	2
UniProt:P35219 CAH8			0.527	2
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.527	6
UniProt:Q8N412 STPG2			0.527	2
UniProt:Q9BSW7 SYT17			0.527	2
UniProt:P05091 ALDH2	1	ALDH2 [mitochondrial matrix] (R-HSA-71718)	0.527	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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