Reactome | TOP1 [nucleoplasm]

TOP1 [nucleoplasm]

Stable Identifier

R-HSA-4641363

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA topoisomerase 1 ecNumber5.99.1.2/ecNumber, TOP1_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of DNA replication proteins (Homo sapiens)
        
        SUMOylation of TOP1 with SUMO1 (Homo sapiens)
        
        TOP1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P11387 TOP1

Gene Names

TOP1

Chain

initiator methionine:1, chain:2-765

Reference Genes

BioGPS Gene:7150 TOP1

COSMIC (genes):TOP1 TOP1

CTD Gene:7150 TOP1

dbSNP Gene:7150 TOP1

ENSEMBL:ENSG00000198900 TOP1

ENSEMBL_homo_sapiens_GENE:ENSG00000198900 TOP1

HGNC:11986 TOP1

KEGG Gene (Homo sapiens):7150 TOP1

Monarch:7150 TOP1

NCBI Gene:7150 TOP1

OMIM:126420 TOP1

UCSC:P11387 TOP1

Reference Transcript

RefSeq:NM_003286.3 TOP1

Other Identifiers

0002060670

1030_s_at

11717437_x_at

11717438_x_at

11717439_s_at

16913737

1710_s_at

19039

1A31

1A35

1A36

1EJ9

1K4S

1K4T

1LPQ

1NH3

1R49

1RR8

1RRJ

1SC7

1SEU

1T8I

1TL8

208900_s_at

208901_s_at

2367108

2367109

2367112

2367113

31680_at

3885465

3885466

3885467

3885468

3885469

3885490

3885491

3885497

3885498

3885499

3885500

3885502

3885507

3885509

3885511

3885512

3885513

3885515

3885517

3885518

3885520

3885521

3885522

3885525

3885526

3885527

3885528

7150

8062603

9058

A_23_P305507

A_33_P3371493

AAA61206

AAA61207

AAA61208

AAB60379

AAB60380

AK292943

AL022394

AL035652

BAF85632

CAA34500

CAA36834

CAB009058

CCDS13312

CH471077

EAW75994

EAW75995

ENSG00000198900

ENSP00000354522

ENST00000361337

ENST00000361337.2

EntrezGene:7150

g339805_3p_a_at

GE57478

GE60513

GO:0000228

GO:0000932

GO:0000978

GO:0001650

GO:0003674

GO:0003677

GO:0003682

GO:0003690

GO:0003697

GO:0003723

GO:0003916

GO:0003917

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0006259

GO:0006260

GO:0006265

GO:0006338

GO:0006464

GO:0007059

GO:0007623

GO:0008150

GO:0008219

GO:0009058

GO:0009330

GO:0009790

GO:0012501

GO:0016032

GO:0016301

GO:0016310

GO:0016853

GO:0018105

GO:0019904

GO:0031298

GO:0032922

GO:0032991

GO:0032993

GO:0034641

GO:0040016

GO:0042493

GO:0043167

GO:0043204

GO:0043226

GO:0044403

GO:0048511

GO:0048856

GO:0051276

GO:0051301

GO:0097100

HGNC:11986

HPA019039

Hs.317.0.S1_3p_a_at

ILMN_1735572

ILMN_1763419

ILMN_2192316

IPR001631

IPR008336

IPR011010

IPR013030

IPR013034

IPR013499

IPR013500

IPR014711

IPR014727

IPR018521

IPR025834

IPR036202

J03250

M27913

M60688

M60689

M60690

M60691

M60692

M60693

M60694

M60695

M60696

M60697

M60698

M60699

M60700

M60701

M60702

M60703

M60704

M60705

M60706

MIM:126420

NM_003286

NP_003277

PF01028

PF02919

PF14370

PH_hs_0040753

PR00416

SM00435

TC20000302.hg

TC20001221.hg

TOP1

TOP1-201

U07804

U07804_s_at

U07806

U07806_s_at

UPI000004F0B1

X16479

X52601

Participant Of

input

SUMOylation of TOP1 with SUMO1

Other forms of this molecule

SUMO1-K117-TOP1 [nucleoplasm]

Inferred To

TOP1 [nucleoplasm] (Bos taurus)

TOP1 [nucleoplasm] (Caenorhabditis elegans)

TOP1 [nucleoplasm] (Canis familiaris)

TOP1 [nucleoplasm] (Danio rerio)

TOP1 [nucleoplasm] (Dictyostelium discoideum)

TOP1 [nucleoplasm] (Drosophila melanogaster)

TOP1 [nucleoplasm] (Gallus gallus)

TOP1 [nucleoplasm] (Mus musculus)

TOP1 [nucleoplasm] (Plasmodium falciparum)

TOP1 [nucleoplasm] (Rattus norvegicus)

TOP1 [nucleoplasm] (Saccharomyces cerevisiae)

TOP1 [nucleoplasm] (Schizosaccharomyces pombe)

TOP1 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_003277.1

ZINC - World Drugs

TOP1_HUMAN

OpenTargets

ENSG00000198900

ZINC - FDA approved

TOP1_HUMAN

ZINC - Substances

TOP1_HUMAN

GeneCards

P11387

ZINC - Biogenic

TOP1_HUMAN

ZINC target

P11387

PRO

P11387

ZINC - Predictions - Purchasable

TOP1_HUMAN

PDB

1RRJ, 1RR8, 1EJ9, 1LPQ, 1A36, 1NH3, 1A31, 1T8I, 1R49, 1K4S, 1SC7, 1TL8, 1K4T, 1A35, 1SEU

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03070 LT			0.734	12
UniProt:Q99801 NKX31			0.626	6
UniProt:P00519 ABL1	5	p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [nucleoplasm] (R-HSA-5686579) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610)	0.602	7
UniProt:P19338 NCL	1	NCL [nucleoplasm] (R-HSA-6791213)	0.59	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.564	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P16403 HIST1H1C	1	HIST1H1C [nucleoplasm] (R-HSA-211237)	0.462	3
UniProt:Q15233 NONO			0.462	2
UniProt:Q6P2Q9 PRPF8	1	PRPF8 [nucleoplasm] (R-HSA-83810)	0.462	2
UniProt:O75643 SNRNP200	1	SNRNP200 [nucleoplasm] (R-HSA-71885)	0.462	2
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2
UniProt:P06748 NPM1	5	p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [cytosol] (R-HSA-3008211) NPM1 [nucleoplasm] (R-HSA-606320) SUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) SUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.462	3
UniProt:Q15717 ELAVL1	6	p-S221,S318-ELAVL1 [cytosol] (R-HSA-450448) p-S158,S221-ELAVL1 [cytosol] (R-HSA-450376) ELAVL1 [cytosol] (R-HSA-450582) p-S221,S318-ELAVL1 [nucleoplasm] (R-HSA-450532) p-S158,S221-ELAVL1 [nucleoplasm] (R-HSA-450576) ELAVL1 [nucleoplasm] (R-HSA-450601)	0.462	3
UniProt:P07910 HNRNPC	2	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543)	0.462	3
UniProt:Q92841 DDX17	2	SUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104) DDX17 [nucleoplasm] (R-HSA-3900090)	0.462	3
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.462	3
UniProt:P09874 PARP1	4	SUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) SUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.462	3
UniProt:Q08211 DHX9	2	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700)	0.462	3
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.462	3
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [nucleoplasm] (R-HSA-71929) HNRNPA2B1 [extracellular exosome] (R-HSA-8950304)	0.462	3
UniProt:P61978 HNRNPK	2	SUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.462	2
UniProt:P11388 TOP2A	3	SUMO2,3-TOP2A [nucleoplasm] (R-HSA-4641298) TOP2A [nucleoplasm] (R-HSA-1362276) SUMO1-K-TOP2A [nucleoplasm] (R-HSA-4641367)	0.462	3
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.462	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.462	3
UniProt:P78527 PRKDC	4	PRKDC [nucleoplasm] (R-HSA-62161) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [cytosol] (R-HSA-3134816) K48polyUb-PRKDC [cytosol] (R-HSA-8938766)	0.462	2
UniProt:P09651 HNRNPA1	1	HNRNPA1 [nucleoplasm] (R-HSA-71927)	0.462	3
UniProt:O43390 HNRNPR	1	HNRNPR [nucleoplasm] (R-HSA-71951)	0.462	3
UniProt:P23246 SFPQ	2	p-Y-SFPQ [nucleoplasm] (R-HSA-8849461) SFPQ [nucleoplasm] (R-HSA-3900138)	0.462	2