Reactome | TFRC(1-760) [cytoplasmic vesicle membrane]

TFRC(1-760) [cytoplasmic vesicle membrane]

Stable Identifier

R-HSA-434196

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytoplasmic vesicle membrane

Synonyms

Transferrin receptor protein 1, TFRC, TFR1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P02786 TFRC

Gene Names

TFRC

Chain

chain:1-760, chain:101-760

Reference Genes

BioGPS Gene:7037 TFRC

COSMIC (genes):TFRC TFRC

CTD Gene:7037 TFRC

dbSNP Gene:7037 TFRC

ENSEMBL:ENSG00000072274 TFRC

HGNC:11763 TFRC

KEGG:hsa:7037 TFRC

Monarch:7037 TFRC

NCBI Gene:7037 TFRC

OMIM:190010 TFRC

UCSC:P02786 TFRC

Reference Transcript

Other Identifiers

11715477_at

11715478_a_at

11756156_s_at

16963241

207332_PM_s_at

207332_s_at

208691_PM_at

208691_at

237214_PM_at

237214_at

237215_PM_s_at

237215_s_at

2712629

2712631

2712633

2712634

2712635

2712636

2712637

2712638

2712639

2712640

2712641

2712642

2712643

2712644

2712645

2712646

2712647

2712648

2712649

2712650

2712652

2712653

2712654

2712655

2712657

2712658

2712659

2712660

2712661

2712662

2712663

2712664

2712665

2712666

2712668

2712669

2712671

2712672

2712673

2712674

2712675

2712676

2712677

2712678

2712679

2712681

2712682

2712683

2712684

2712685

2712692

37324_at

51674_at

63276_r_at

7037

8093053

89367_at

AFFX-HUMTFRR/M11507_3_at

AFFX-HUMTFRR/M11507_5_at

AFFX-HUMTFRR/M11507_M_at

A_23_P212617

A_24_P669329

GE81249

GO:0001618

GO:0001666

GO:0001934

GO:0003013

GO:0003723

GO:0003725

GO:0004998

GO:0005515

GO:0005576

GO:0005615

GO:0005768

GO:0005769

GO:0005886

GO:0005905

GO:0006355

GO:0006826

GO:0006879

GO:0006897

GO:0006953

GO:0006954

GO:0007165

GO:0007584

GO:0009897

GO:0009986

GO:0010008

GO:0010039

GO:0010042

GO:0010628

GO:0010637

GO:0016020

GO:0016192

GO:0016323

GO:0019901

GO:0030154

GO:0030316

GO:0030544

GO:0030669

GO:0030890

GO:0031334

GO:0031410

GO:0031623

GO:0032526

GO:0033138

GO:0033572

GO:0035556

GO:0038024

GO:0042102

GO:0042470

GO:0042802

GO:0042803

GO:0043066

GO:0043123

GO:0043226

GO:0043231

GO:0044877

GO:0045780

GO:0045830

GO:0046688

GO:0046718

GO:0048471

GO:0051087

GO:0051092

GO:0055037

GO:0055038

GO:0060586

GO:0070062

GO:0071466

GO:0072562

GO:0098794

GO:0098944

GO:0098978

GO:0099072

GO:0150104

GO:1900182

GO:1903561

GO:1990712

GO:1990830

HMNXSV003030758

Hs.185726.0.A1_3p_at

PH_hs_0022877

TC03002155.hg

X01060_at

g4507456_3p_a_at

Participates

as a candidate of

Golgi-associated Vesicle Cargo [cytoplasmic vesicle membrane] (Homo sapiens)

Other forms of this molecule

TFRC(1-760) [plasma membrane]

TFRC(1-760) [endosome membrane]

TFRC(1-760) [Golgi membrane]

TFRC(1-760) [clathrin-coated endocytic vesicle membrane]

Inferred To

TRE2 [cytoplasmic vesicle membrane] (Saccharomyces cerevisiae)

Homologues of TFRC(1-760) [cytoplasmic vesicle membrane] (Caenorhabditis elegans)

Homologues of TFRC(1-760) [cytoplasmic vesicle membrane] (Saccharomyces cerevisiae)

Homologues of TFRC(1-760) [cytoplasmic vesicle membrane] (Sus scrofa)

TRE1 [cytoplasmic vesicle membrane] (Saccharomyces cerevisiae)

TFRC(1-760) [cytoplasmic vesicle membrane] (Caenorhabditis elegans)

TFRC(1-760) [cytoplasmic vesicle membrane] (Gallus gallus)

TFRC(1-760) [cytoplasmic vesicle membrane] (Saccharomyces cerevisiae)

TFRC [cytoplasmic vesicle membrane] (Bos taurus)

TFRC [cytoplasmic vesicle membrane] (Canis familiaris)

TFRC [cytoplasmic vesicle membrane] (Sus scrofa)

Tfrc [cytoplasmic vesicle membrane] (Mus musculus)

Tfrc [cytoplasmic vesicle membrane] (Rattus norvegicus)

gcp-2.2 [cytoplasmic vesicle membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_003225.2, NP_001300894.1, NP_001300895.1, NP_001121620.1

Guide to Pharmacology - Targets

3196

OpenTargets

ENSG00000072274

ENSEMBL

ENSP00000513654, ENSP00000376197, ENSP00000353224, ENST00000698291, ENST00000698280, ENST00000392396, ENSP00000513646

HPA

ENSG00000072274-TFRC

PRO

P02786

Pharos - Targets

P02786

Orphanet

TFRC

GlyGen

P02786

HMDB Protein

HMDBP02577

PDB

3S9N, 6W3H, 2NSU, 3S9M, 6WRX, 6D05, 7ZQS, 6WRW, 3S9L, 6OKD, 6H5I, 6D04, 1CX8, 6GSR, 6D03, 6WRV, 3KAS, 8P0Z, 6Y76, 1SUV, 1DE4

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02787 TF	6	TF [endoplasmic reticulum lumen] (R-HSA-8956763) p-TF [endoplasmic reticulum lumen] (R-HSA-8957001) apoTF [endosome membrane] (R-HSA-917974) apoTF [extracellular region] (R-HSA-350754) TF [secretory granule lumen] (R-HSA-350704) apoTF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869140)	0.852	7
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.671	4
UniProt:Q9P0V3 SH3BP4	1	SH3BP4 [cytosol] (R-HSA-8866227)	0.668	6
UniProt:Q30201 HFE	1	HFE [plasma membrane] (R-HSA-5691126)	0.621	3
UniProt:P21926 CD9	4	CD9 [plasma membrane] (R-HSA-51717) CD9 [endocytic vesicle membrane] (R-HSA-5334774) CD9 [clathrin-coated endocytic vesicle membrane] (R-HSA-5334779) CD9 [platelet alpha granule membrane] (R-HSA-114585)	0.597	3
UniProt:P61769 B2M	11	B2M(21-119) [plasma membrane] (R-HSA-167743) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [early endosome membrane] (R-HSA-182298)	0.564	3
UniProt:P02768 ALB	7	ALB(19-609) [extracellular region] (R-HSA-114609) ALB [platelet alpha granule lumen] (R-HSA-49865) salicyl-ALB [extracellular region] (R-HSA-9750694) acetyl-ALB [extracellular region] (R-HSA-9749660) ALB [extracellular region] (R-HSA-194115) p-ALB [endoplasmic reticulum lumen] (R-HSA-8956930) ALB [endoplasmic reticulum lumen] (R-HSA-8956690)	0.558	2
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:Q14973 SLC10A1	1	SLC10A1 [plasma membrane] (R-HSA-194116)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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