Reactome | ASF1A [nucleoplasm]

ASF1A [nucleoplasm]

Stable Identifier

R-HSA-417169

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone chaperone ASF1A, ASF1A_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9Y294 ASF1A

Gene Names

ASF1A, CGI-98, HSPC146

Chain

chain:1-204

Reference Genes

BioGPS Gene:25842 ASF1A

COSMIC (genes):ASF1A ASF1A

CTD Gene:25842 ASF1A

dbSNP Gene:25842 ASF1A

ENSEMBL:ENSG00000111875 ASF1A

HGNC:20995 ASF1A

KEGG Gene (Homo sapiens):25842 ASF1A

Monarch:25842 ASF1A

NCBI Gene:25842 ASF1A

OMIM:609189 ASF1A

UCSC:Q9Y294 ASF1A

Reference Transcript

RefSeq:NM_014034.2 ASF1A

Other Identifiers

0004280048

11720788_at

11720789_at

11720790_s_at

17012108

203427_at

203428_s_at

25842

2923361

2923363

2923365

2923366

2923367

2923368

39806_at

8121734

A_23_P19219

GE79712

GO:0000228

GO:0000790

GO:0001649

GO:0003674

GO:0003682

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0006259

GO:0006281

GO:0006325

GO:0006333

GO:0006334

GO:0006335

GO:0006336

GO:0006950

GO:0008150

GO:0009058

GO:0022607

GO:0030154

GO:0031936

GO:0032991

GO:0034641

GO:0042393

GO:0042692

GO:0043226

GO:0048856

GO:0051276

GO:0065003

ILMN_1658285

ILMN_1714737

PH_hs_0023538

TC06000937.hg

g7661591_3p_at

g8439508_3p_a_at

Participant Of

input

Initiation of SAHF formation

hasComponent

HIRA:ASF1A:UBN1:CABIN1 [nucleoplasm]

Inferred To

ASF1 [nucleoplasm] (Saccharomyces cerevisiae)

asf1 [nucleoplasm] (Dictyostelium discoideum)

asf1 [nucleoplasm] (Drosophila melanogaster)

Asf1a [nucleoplasm] (Mus musculus)

Asf1a [nucleoplasm] (Rattus norvegicus)

cia1 [nucleoplasm] (Schizosaccharomyces pombe)

unc-85 [nucleoplasm] (Caenorhabditis elegans)

ASF1A [nucleoplasm] (Bos taurus)

ASF1A [nucleoplasm] (Canis familiaris)

ASF1A [nucleoplasm] (Plasmodium falciparum)

ASF1A [nucleoplasm] (Sus scrofa)

ASF1A [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_054753.1

OpenTargets

ENSG00000111875

ZINC - Substances

ASF1A_HUMAN

HPA

ENSG00000111875-ASF1A

GeneCards

Q9Y294

Ensembl

ENSP00000229595, ENSG00000111875, ENST00000229595

ZINC target

Q9Y294

PRO

Q9Y294

ZINC - Predictions - Purchasable

ASF1A_HUMAN

PDB

2IO5, 5C3I, 1TEY, 6F0H, 2IIJ, 6F0F, 6F0G, 2I32, 3AAD

Interactors (27)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62805 H4C1	19	SUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) HIST1H4A [extracellular region] (R-HSA-977569) SUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-4568749) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK-HIST1H4A [nucleoplasm] (R-HSA-2172676) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.951	15
UniProt:P54198 HIRA	1	HIRA [nucleoplasm] (R-HSA-2532790)	0.868	14
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.855	10
UniProt:P68431 H3C1	59	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) HIST1H3A [extracellular region] (R-HSA-977570) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) AcK19-HIST1H3A [nucleoplasm] (R-HSA-4568761) AcK5-HIST1H3A [nucleoplasm] (R-HSA-4568751) AcK24-HIST1H3A [nucleoplasm] (R-HSA-4568754) AcK15-HIST1H3A [nucleoplasm] (R-HSA-4568743) Ack15-HIST1H3A [nucleoplasm] (R-HSA-4549217) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) MeR27-HIST1H3A [nucleoplasm] (R-HSA-5229050) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4754188) Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4754169) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791) Me3K80-HIST1H3A [nucleoplasm] (R-HSA-5649795) Me2K80-HIST1H3A [nucleoplasm] (R-HSA-5649768) Me3K37-HIST1H3A [nucleoplasm] (R-HSA-5638160) Me2K37-HIST1H3A [nucleoplasm] (R-HSA-4722125) MeK10-HIST1H3A [nucleoplasm] (R-HSA-212105) MeK28-HIST1H3A [nucleoplasm] (R-HSA-5638327) MeK-10-HIST1H3A [cytosol] (R-HSA-8943830) HIST1H3A [cytosol] (R-HSA-8943829) Me2aR3-HIST1H3A [nucleoplasm] (R-HSA-5244526) MeK5-HIST1H3A [nucleoplasm] (R-HSA-4687016) Cit27-HIST1H3A [nucleoplasm] (R-HSA-5246532) Cit3-HIST1H3A [nucleoplasm] (R-HSA-5246544) Cit9-HIST1H3A [nucleoplasm] (R-HSA-5246530) Cit18-HIST1H3A [nucleoplasm] (R-HSA-5246534) MeR18-HIST1H3A [nucleoplasm] (R-HSA-5229059) MeR3-HIST1H3A [nucleoplasm] (R-HSA-5244529) MeR27-HIST1H3A [nucleoplasm] (R-HSA-5244801) MeR9-HIST1H3A [nucleoplasm] (R-HSA-5244806) Ack10-HIST1H3A [nucleoplasm] (R-HSA-4568939) Me2K10-HIST1H3A [nucleoplasm] (R-HSA-427378) Me2K5,Me2aR3-HIST1H3A [nucleoplasm] (R-HSA-8936572) p-T12, Me2K-10-HIST1H3A [nucleoplasm] (R-HSA-5625790) p-T12-HIST1H3A [nucleoplasm] (R-HSA-5625872) p-T12,MeK-10-HIST1H3A [nucleoplasm] (R-HSA-5625859) p-T12, Me3K-10-HIST1H3A [nucleoplasm] (R-HSA-5625757) Me3K-10-HIST1H3A [nucleoplasm] (R-HSA-427734) Me3K5-HIST1H3A [nucleoplasm] (R-HSA-1214186) HIST1H3A [nucleoplasm] (R-HSA-212070) Me3K-28-HIST1H3A [nucleoplasm] (R-HSA-212220) Me2K5-HIST1H3A [nucleoplasm] (R-HSA-1214170)	0.855	9
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.725	4
UniProt:P79522 PRR3			0.718	6
UniProt:Q13112 CAF1B			0.656	3
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.647	4
UniProt:Q9Y6J0 CABIN1	1	CABIN1 [nucleoplasm] (R-HSA-3878125)	0.643	3
UniProt:Q8IWY9 CDAN1			0.643	4
UniProt:Q9Y2V0 CDIN1			0.643	3
UniProt:P62799 H4			0.632	4
UniProt:P84233 Histone H3.2	2	Histone H3.2 [nucleoplasm] (R-XLA-4549227) Ack15-histone H3.2 [nucleoplasm] (R-XLA-4549248)	0.632	4
UniProt:Q71DI3 H3C15	57	MeK-HIST2H3A [nucleoplasm] (R-HSA-417240) HIST2H3A [extracellular region] (R-HSA-977578) 2xAcK-HIST2H3A [nucleoplasm] (R-HSA-427525) AcK24-HIST2H3A [nucleoplasm] (R-HSA-4568747) AcK19-HIST2H3A [nucleoplasm] (R-HSA-4568750) AcK15-HIST2H3A [nucleoplasm] (R-HSA-4568755) AcK5-HIST2H3A [nucleoplasm] (R-HSA-4568752) Ack15-HIST2H3A [nucleoplasm] (R-HSA-4549224) Me2aR27-HIST2H3A [nucleoplasm] (R-HSA-5229057) MeR27-HIST2H3A [nucleoplasm] (R-HSA-5229060) Me2aR18-HIST2H3A [nucleoplasm] (R-HSA-5229063) Me2sR9-HIST2H3A [nucleoplasm] (R-HSA-5211327) Me2sR3-HIST2H3A [nucleoplasm] (R-HSA-5218930) AcK9,14-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8870892) AcK14,18,79-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8871273) AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871304) AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871292) AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8865607) AcK14,18-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8871296) AcK14,18,79-p-T11-HIST2H3A [nucleoplasm] (R-HSA-8871290) AcK14,18-p-T11-HIST2H3A [nucleoplasm] (R-HSA-8871302) AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871289) Me3K10-HIST2H3A [nucleoplasm] (R-HSA-4754191) Me3K28-HIST2H3A [nucleoplasm] (R-HSA-4754178) Me2K28-HIST2H3A [nucleoplasm] (R-HSA-4754197) Me2K10-HIST2H3A [nucleoplasm] (R-HSA-4724280) MeK37-HIST2H3A [nucleoplasm] (R-HSA-4722131) MeK80-HIST2H3A [nucleoplasm] (R-HSA-5649805) Me3K80-HIST2H3A [nucleoplasm] (R-HSA-5649798) Me2K80-HIST2H3A [nucleoplasm] (R-HSA-5649803) Me3K37-HIST2H3A [nucleoplasm] (R-HSA-5638140) Me2K37-HIST2H3A [nucleoplasm] (R-HSA-4722126) MeK10-HIST2H3A [nucleoplasm] (R-HSA-4724283) MeK28-HIST2H3A [nucleoplasm] (R-HSA-5638326) MeK10-HIST2H3A [cytosol] (R-HSA-8943828) HIST2H3A [cytosol] (R-HSA-8943831) Me2aR3-HIST2H3A [nucleoplasm] (R-HSA-5244518) MeK5-HIST2H3A [nucleoplasm] (R-HSA-4687009) Cit27-HIST2H3A [nucleoplasm] (R-HSA-5246539) Cit9-HIST2H3A [nucleoplasm] (R-HSA-5246545) Cit18-HIST2H3A [nucleoplasm] (R-HSA-5246536) MeR18-HIST2H3A [nucleoplasm] (R-HSA-5229044) MeR3-HIST2H3A [nucleoplasm] (R-HSA-5244520) MeR27-HIST2H3A [nucleoplasm] (R-HSA-5244804) MeR9-HIST2H3A [nucleoplasm] (R-HSA-5244803) Ack10-HIST2H3A [nucleoplasm] (R-HSA-4568924) Me2K-10-HIST2H3A [nucleoplasm] (R-HSA-427407) Me2K5,Me2aR3-HIST2H3A [nucleoplasm] (R-HSA-8936570) p-T12, Me2K-10-HIST2H3A [nucleoplasm] (R-HSA-5625792) p-T12-HIST2H3A [nucleoplasm] (R-HSA-5625871) p-T12,MeK-HIST2H3A [nucleoplasm] (R-HSA-5625857) p-T12, Me3K-10-HIST2H3A [nucleoplasm] (R-HSA-5625754) Me3K-10-HIST2H3A [nucleoplasm] (R-HSA-427744) Me3K5-HIST2H3A [nucleoplasm] (R-HSA-1214223) HIST2H3A [nucleoplasm] (R-HSA-212281) Me3K-28-HIST2H3A [nucleoplasm] (R-HSA-212253) Me2K5-HIST2H3A [nucleoplasm] (R-HSA-1214225)	0.576	4
UniProt:P49321-2 NASP			0.556	3
UniProt:Q12161 PSH1			0.556	3
UniProt:P02309	14	HHF2 [nucleoplasm] (R-SCE-212078) HHF2 [nucleoplasm] (R-SCE-4570518) HHF2 [nucleoplasm] (R-SCE-4568744) HHF2 [nucleoplasm] (R-SCE-4568748) HHF2 [nucleoplasm] (R-SCE-427469) HHF2 [nucleoplasm] (R-SCE-4568758) HHF2 [nucleoplasm] (R-SCE-5229015) HHF2 [nucleoplasm] (R-SCE-4754243) HHF2 [nucleoplasm] (R-SCE-4754240) HHF2 [nucleoplasm] (R-SCE-5651656) HHF2 [nucleoplasm] (R-SCE-3451124) HHF2 [nucleoplasm] (R-SCE-2172676) HHF2 [nucleoplasm] (R-SCE-181902) HHF2 [nucleoplasm] (R-SCE-5651652)	0.556	3
UniProt:Q9NPG3 UBN1	1	UBN1 [nucleoplasm] (R-HSA-2532791)	0.527	5
UniProt:P49321 NASP			0.527	3
UniProt:Q86UE8-2 TLK2			0.527	2
UniProt:O14929 HAT1	1	HAT1 [nucleoplasm] (R-HSA-3662337)	0.527	2
UniProt:Q5UIP0-2 RIF1			0.527	2
UniProt:Q9NPG3-2 UBN1			0.527	2
UniProt:Q9NVP2 ASF1B			0.527	2
UniProt:Q6ZU65 UBN2			0.527	2
UniProt:Q96HA7 TONSL			0.527	3
UniProt:P84243 H3-3A	15	MeK-H3F3A [nucleoplasm] (R-HSA-427369) H3F3A [extracellular region] (R-HSA-977567) 2xAcK-H3F3A [nucleoplasm] (R-HSA-427504) AcK10-H3F3A [nucleoplasm] (R-HSA-5250654) Me2K-10-H3F3A [nucleoplasm] (R-HSA-427324) Me2K5,Me2aR2-H3F3A [nucleoplasm] (R-HSA-8936573) p-T12, Me2K-10-H3F3A [nucleoplasm] (R-HSA-5625800) p-T12-H3F3A [nucleoplasm] (R-HSA-5625878) p-T12,MeK-H3F3A [nucleoplasm] (R-HSA-5625858) p-T12,Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625758) Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625747) Me3K5-H3F3A [nucleoplasm] (R-HSA-1214216) H3F3A [nucleoplasm] (R-HSA-212295) Me3K-28-H3F3A [nucleoplasm] (R-HSA-212282) Me2K5-H3F3A [nucleoplasm] (R-HSA-1214206)	0.462	3