Reactome | TOP2B [nucleoplasm]

TOP2B [nucleoplasm]

Stable Identifier

R-HSA-4641359

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA topoisomerase 2-beta ecNumber5.99.1.3/ecNumber, TOP2B_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q02880 TOP2B

Gene Names

TOP2B

Chain

initiator methionine:, chain:2-1626

Reference Genes

BioGPS Gene:7155 TOP2B

COSMIC (genes):TOP2B TOP2B

CTD Gene:7155 TOP2B

dbSNP Gene:7155 TOP2B

ENSEMBL:ENSG00000077097 TOP2B

HGNC:11990 TOP2B

KEGG:hsa:7155 TOP2B

Monarch:7155 TOP2B

NCBI Gene:7155 TOP2B

OMIM:126431 TOP2B

UCSC:Q02880 TOP2B

Reference Transcript

Participates

as an input of

SUMOylation of TOP2B with SUMO1 (Homo sapiens)

Other forms of this molecule

monoSUMO1-K-TOP2B [nucleoplasm]

Inferred To

cin-4 [nucleoplasm] (Caenorhabditis elegans)

top2b [nucleoplasm] (Xenopus tropicalis)

Top2b [nucleoplasm] (Rattus norvegicus)

Homologues of TOP2B [nucleoplasm] (Caenorhabditis elegans)

Homologues of TOP2B [nucleoplasm] (Dictyostelium discoideum)

TOP2B [nucleoplasm] (Bos taurus)

TOP2B [nucleoplasm] (Caenorhabditis elegans)

TOP2B [nucleoplasm] (Canis familiaris)

TOP2B [nucleoplasm] (Dictyostelium discoideum)

TOP2B [nucleoplasm] (Drosophila melanogaster)

TOP2B [nucleoplasm] (Gallus gallus)

TOP2B [nucleoplasm] (Mus musculus)

TOP2B [nucleoplasm] (Plasmodium falciparum)

TOP2B [nucleoplasm] (Saccharomyces cerevisiae)

TOP2B [nucleoplasm] (Schizosaccharomyces pombe)

TOP2B [nucleoplasm] (Sus scrofa)

Cross References

OpenTargets

ENSG00000077097

ENSEMBL

ENST00000435706, ENSP00000396704, ENSG00000077097, ENSP00000264331, ENST00000264331

HPA

ENSG00000077097-TOP2B

GeneCards

TOP2B

ZINC - Substances

TOP2B_HUMAN

ZINC target

Q02880

PRO

Q02880

Pharos - Targets

Q02880

Orphanet

TOP2B

GlyGen

Q02880

PDB

4G0W, 5ZQF, 7QFN, 7ZBG, 7QFO, 5ZAD, 8KE7, 5GWJ, 5GWI, 7YQ8, 5ZEN, 4G0U, 4J3N, 3QX3, 5ZRF, 4G0V

HMDB Protein

HMDBP02207

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22415 USF1	2	USF1 [nucleoplasm] (R-HSA-9023562) pT153 USF1 [nucleoplasm] (R-HSA-9855887)	0.558	3
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	2
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.527	2
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.499	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2
UniProt:P46531 NOTCH1	20	NOTCH1 L1678P S2 cleavage fragment [extracellular region] (R-HSA-2730745) NOTCH1 I1680N S2 cleavage fragment [extracellular region] (R-HSA-2730744) NOTCH1 I1718T S2 cleavage fragment [extracellular region] (R-HSA-2730757) NOTCH1 A1701P S2 cleavage fragment [plasma membrane] (R-HSA-2730742) NOTCH1 V1676D S2 cleavage fragment [extracellular region] (R-HSA-2730755) NOTCH1 I1680N Transmembrane Fragment [plasma membrane] (R-HSA-2684869) NOTCH1 I1718T Transmembrane Fragment [plasma membrane] (R-HSA-2684881) NOTCH1 I1616T Extracellular Fragment [extracellular region] (R-HSA-2684866) NOTCH1 L1596H Extracellular Fragment [extracellular region] (R-HSA-2684853) NOTCH1 L1678P Transmembrane Fragment [plasma membrane] (R-HSA-1485591) NOTCH1 A1701P Transmembrane Fragment [plasma membrane] (R-HSA-1485585) NOTCH1 I1616N Extracellular Fragment [extracellular region] (R-HSA-2684862) NOTCH1 L1593P Extracellular Fragment [extracellular region] (R-HSA-1485584) NOTCH1 R1598P Extracellular Fragment [extracellular region] (R-HSA-1485592) NOTCH1 V1576E Extracellular Fragment [extracellular region] (R-HSA-2684852) NOTCH1 V1676D Transmembrane Fragment [plasma membrane] (R-HSA-2684874) NOTCH1 F1592S Extracellular Fragment [extracellular region] (R-HSA-2684847) NOTCH1 L1574Q Extracellular Fragment [extracellular region] (R-HSA-2691203) p-NICD1 Q2440* [nucleoplasm] (R-HSA-2902207) p-NICD1 Q2395* [nucleoplasm] (R-HSA-2902205)	0.462	2