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ACTC1 [cytosol]
Stable Identifier
R-HSA-390536
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Actin, alpha cardiac muscle 1, ACTC_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Formation of the dystrophin-glycoprotein complex (DGC) (Homo sapiens)
DGC complex binds AGRN and HSPG2 (Homo sapiens)
DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTC1 [cytosol] (Homo sapiens)
DGC complex:laminins:F-actin:AGRN,HSPG2 [plasma membrane] (Homo sapiens)
DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTC1 [cytosol] (Homo sapiens)
DGC:laminin complex binds F-actin (Homo sapiens)
DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTC1 [cytosol] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTC1 [cytosol] (Homo sapiens)
Muscle contraction (Homo sapiens)
Striated Muscle Contraction (Homo sapiens)
ATP Hydrolysis By Myosin (Homo sapiens)
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
alpha Actin Chain [cytosol] (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTC1 [cytosol] (Homo sapiens)
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
alpha Actin Chain [cytosol] (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTC1 [cytosol] (Homo sapiens)
Calcium Binds Troponin-C (Homo sapiens)
Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
alpha Actin Chain [cytosol] (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTC1 [cytosol] (Homo sapiens)
Inactive Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament [cytosol] (Homo sapiens)
alpha Actin Chain [cytosol] (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTC1 [cytosol] (Homo sapiens)
Myosin Binds ATP (Homo sapiens)
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
alpha Actin Chain [cytosol] (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTC1 [cytosol] (Homo sapiens)
Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
alpha Actin Chain [cytosol] (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTC1 [cytosol] (Homo sapiens)
Release Of ADP From Myosin (Homo sapiens)
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
alpha Actin Chain [cytosol] (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTC1 [cytosol] (Homo sapiens)
Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
alpha Actin Chain [cytosol] (Homo sapiens)
alpha Actin [cytosol] (Homo sapiens)
ACTC1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOA GTPase cycle (Homo sapiens)
RHOA binds effectors at the plasma membrane (Homo sapiens)
RHOA plasma membrane effectors [cytosol] (Homo sapiens)
ACTC1 [cytosol] (Homo sapiens)
RHOA:GTP:cytosolic RHOA effectors [plasma membrane] (Homo sapiens)
RHOA plasma membrane effectors [cytosol] (Homo sapiens)
ACTC1 [cytosol] (Homo sapiens)
RHOB GTPase cycle (Homo sapiens)
RHOB binds effectors at the plasma membrane (Homo sapiens)
RHOB effectors (plasma membrane) [cytosol] (Homo sapiens)
ACTC1 [cytosol] (Homo sapiens)
RHOB:GTP:cytosolic RHOB effectors [plasma membrane] (Homo sapiens)
RHOB effectors (plasma membrane) [cytosol] (Homo sapiens)
ACTC1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P68032 ACTC1
Gene Names
ACTC1, ACTC
Chain
initiator methionine:, chain:2-377, chain:3-377
Reference Genes
BioGPS Gene:70 ACTC1
COSMIC (genes):ACTC1 ACTC1
CTD Gene:70 ACTC1
dbSNP Gene:70 ACTC1
ENSEMBL:ENSG00000159251 ACTC1
HGNC:143 ACTC1
Monarch:70 ACTC1
NCBI Gene:70 ACTC1
OMIM:102540 ACTC1
UCSC:P68032 ACTC1
Reference Transcript
RefSeq:NM_005159.4 ACTC1
Other Identifiers
11720489_a_at
16807014
205132_PM_at
205132_at
3617723
3617724
3617725
3617726
3617727
3617728
3617729
3617730
3617732
3617733
3617734
3617735
3617736
3617737
3617738
3617739
39063_at
53330_at
70
7987315
A_23_P205894
A_24_P121535
GE60487
GO:0000146
GO:0003013
GO:0003774
GO:0003824
GO:0005515
GO:0005524
GO:0005615
GO:0005737
GO:0005829
GO:0005856
GO:0005884
GO:0005925
GO:0007010
GO:0007015
GO:0008092
GO:0010628
GO:0016020
GO:0016787
GO:0017022
GO:0030017
GO:0030027
GO:0030048
GO:0030175
GO:0030240
GO:0031032
GO:0031674
GO:0033275
GO:0043066
GO:0043226
GO:0044297
GO:0045202
GO:0055003
GO:0055008
GO:0060047
GO:0070062
GO:0070252
GO:0072562
GO:0090131
GO:0098978
GO:0140657
HMNXSV003057505
ILMN_1658660
J00073_at
PH_hs_0006487
TC15001201.hg
g10938011_3p_at
Participates
as a candidate of
RHOA plasma membrane effectors [cytosol] (Homo sapiens)
RHOB effectors (plasma membrane) [cytosol] (Homo sapiens)
as a member of
alpha Actin [cytosol] (Homo sapiens)
Inferred To
Act88F [cytosol]
(Drosophila melanogaster)
actc1 [cytosol]
(Xenopus tropicalis)
Actc1 [cytosol]
(Mus musculus)
Actc1 [cytosol]
(Rattus norvegicus)
ACTC1 [cytosol]
(Bos taurus)
ACTC1 [cytosol]
(Canis familiaris)
ACTC1 [cytosol]
(Gallus gallus)
ACTC1 [cytosol]
(Sus scrofa)
actc2 [cytosol]
(Danio rerio)
act1 [cytosol]
(Schizosaccharomyces pombe)
ACT1 [cytosol]
(Saccharomyces cerevisiae)
Cross References
ENSEMBL
ENST00000290378
,
ENSP00000290378
OpenTargets
ENSG00000159251
HPA
ENSG00000159251-ACTC1
PRO
P68032
Pharos - Targets
P68032
GlyGen
P68032
Orphanet
ACTC1
PDB
9B3Q
,
8GT3
,
8GT1
,
8GSU
,
8GSW
,
9B3R
,
8GT5
,
8GT4
,
8GT2
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.569
9
UniProt:P23528 CFL1
3
CFL1 [cytosol]
(R-HSA-350751)
p-S3-CFL1 [cytosol]
(R-HSA-399813)
CFL1 [extracellular region]
(R-HSA-350747)
0.564
2
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.462
2
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