Reactome | DKC1 [nucleoplasm]

DKC1 [nucleoplasm]

Stable Identifier

R-HSA-163102

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Dyskerin

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O60832 DKC1

Gene Names

DKC1, NOLA4

Chain

initiator methionine:, chain:2-514

Reference Genes

BioGPS Gene:1736 DKC1

COSMIC (genes):DKC1 DKC1

CTD Gene:1736 DKC1

dbSNP Gene:1736 DKC1

ENSEMBL:ENSG00000130826 DKC1

HGNC:2890 DKC1

KEGG:hsa:1736 DKC1

Monarch:1736 DKC1

NCBI Gene:1736 DKC1

OMIM:300126 DKC1

UCSC:O60832 DKC1

Reference Transcript

Other Identifiers

11743467_at

11743468_at

11757159_at

17108500

17119800

17119802

1736

201478_PM_s_at

201478_s_at

201479_PM_at

201479_at

216212_PM_s_at

216212_s_at

34829_at

3996668

3996669

3996670

3996671

3996672

3996673

3996674

3996675

3996676

3996677

3996678

3996679

3996680

3996681

3996683

3996684

3996685

3996686

3996687

3996688

3996689

3996690

3996691

3996692

3996693

3996694

3996695

3996696

3996698

8170971

8170990

8170992

A_14_P126139

A_14_P134589

A_21_P0000323

A_21_P0000324

A_21_P0000338

A_23_P137143

A_32_P91906

GE54597

GO:0000455

GO:0000495

GO:0001522

GO:0001650

GO:0003720

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005697

GO:0005730

GO:0005737

GO:0006364

GO:0006396

GO:0007004

GO:0009451

GO:0009982

GO:0015030

GO:0016071

GO:0016073

GO:0016740

GO:0016853

GO:0031118

GO:0031120

GO:0031429

GO:0032200

GO:0032212

GO:0033979

GO:0034513

GO:0042254

GO:0043226

GO:0070034

GO:0072589

GO:0090661

GO:0090666

GO:0090669

GO:0140097

GO:1904867

GO:1904872

GO:1904874

GO:1990481

GO:1990904

HMNXSV003016875

HMNXSV003031242

HMNXSV003046464

Hs.4747.1.S1_3p_a_at

ILMN_1671257

PH_hs_0000480

RNA33510|snoRNA_scaRNA_106_132

RNA33526|snoRNA_scaRNA_122_129

TC0X000779.hg

g2737893_3p_a_at

g4503336_3p_at

Participates

as a component of

as an input of

Inferred To

cbf5 [nucleoplasm] (Schizosaccharomyces pombe)

Nop60B [nucleoplasm] (Drosophila melanogaster)

Dkc1 [nucleoplasm] (Mus musculus)

Dkc1 [nucleoplasm] (Rattus norvegicus)

nola4 [nucleoplasm] (Dictyostelium discoideum)

DKC1 [nucleoplasm] (Bos taurus)

DKC1 [nucleoplasm] (Caenorhabditis elegans)

DKC1 [nucleoplasm] (Canis familiaris)

DKC1 [nucleoplasm] (Gallus gallus)

DKC1 [nucleoplasm] (Plasmodium falciparum)

DKC1 [nucleoplasm] (Sus scrofa)

CBF5 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001135935.1, NP_001354.1, NP_001275676.1

OpenTargets

ENSG00000130826

ENSEMBL

ENST00000369550, ENSP00000358563

HPA

ENSG00000130826-DKC1

PRO

O60832

Pharos - Targets

O60832

GlyGen

O60832

Orphanet

DKC1

HMDB Protein

HMDBP01675

PDB

7BGB, 8OUF, 7V9A, 8OUE, 7TRC

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96HR8 NAF1			0.9	12
UniProt:Q9NPE3 NOP10	1	NOP10 [nucleoplasm] (R-HSA-6790665)	0.85	10
UniProt:Q9BUR4 WRAP53	2	WRAP53 [nucleoplasm] (R-HSA-418386) Unfolded WRAP53 [cytosol] (R-HSA-6813830)	0.835	9
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.824	10
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.812	9
UniProt:Q9NY12 GAR1	1	GAR1 [nucleoplasm] (R-HSA-6790707)	0.793	6
UniProt:O14746 TERT	1	TERT [nucleoplasm] (R-HSA-163076)	0.745	4
UniProt:Q9NX24 NHP2	1	NHP2 [nucleoplasm] (R-HSA-418325)	0.731	4
UniProt:Q6PI26 SHQ1	1	SHQ1 [nucleoplasm] (R-HSA-9671152)	0.669	5
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.643	3
UniProt:Q9NX58 LYAR			0.564	3
UniProt:P62241 RPS8	2	RPS8 [cytosol] (R-HSA-72385) RPS8 [nucleoplasm] (R-HSA-6791203)	0.527	2
UniProt:Q13247 SRSF6	1	SRSF6 [nucleoplasm] (R-HSA-72026)	0.527	3
UniProt:P08621 SNRNP70	1	SNRNP70 [nucleoplasm] (R-HSA-71913)	0.527	4
UniProt:P08865 RPSA	2	RPSA [cytosol] (R-HSA-72389) RPSA [nucleoplasm] (R-HSA-6798722)	0.527	2
UniProt:Q9NQZ8 ZNF71	1	ZNF71 [nucleoplasm] (R-HSA-2454145)	0.527	2
UniProt:P22492 H1T			0.527	3
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.527	2
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	2
UniProt:P06276 BCHE	2	BCHE [plasma membrane] (R-HSA-3640835) BCHE [extracellular region] (R-HSA-434469)	0.527	2
UniProt:P01127 PDGFB	8	PDGFB(82-241) [platelet alpha granule lumen] (R-HSA-387075) PDGFB(21-81) [platelet alpha granule lumen] (R-HSA-184200) PDGFB(191-241) [Golgi lumen] (R-HSA-396945) PDGFB(1-81) [Golgi lumen] (R-HSA-389058) PDGFB(1-241) [Golgi membrane] (R-HSA-380740) PDGFB(1-241) [endoplasmic reticulum lumen] (R-HSA-381903) PDGFB(82-241) [extracellular region] (R-HSA-381904) PDGFB (82-190) [extracellular region] (R-HSA-184201)	0.527	2
UniProt:P46779 RPL28	1	RPL28 [cytosol] (R-HSA-72444)	0.527	2
UniProt:Q07020 RPL18	1	RPL18 [cytosol] (R-HSA-72420)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	3
UniProt:Q8IXZ2 ZC3H3			0.527	2
UniProt:P50914 RPL14	1	RPL14 [cytosol] (R-HSA-72414)	0.527	3
UniProt:Q9NZM5 NOP53			0.527	3
UniProt:P42696 RBM34			0.527	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	3
UniProt:Q8WV16 DCAF4	1	DCAF4 [nucleoplasm] (R-HSA-8955191)	0.527	4
UniProt:Q6NT76 HMBX1			0.499	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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