Reactome | EIF4A1 [cytosol]

EIF4A1 [cytosol]

Stable Identifier

R-HSA-72573

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF4A-I, eIF4AI, eIF-4A-I, eukaryotic initiation factor 4A-I, Eukaryotic initiation factor 4A-I

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External Reference Information

External Reference

UniProt:P60842 EIF4A1

Gene Names

EIF4A1, DDX2A, EIF4A

Chain

initiator methionine:1, chain:2-406, initiator methionine:1

Reference Genes

BioGPS Gene:1973 EIF4A1

COSMIC (genes):EIF4A1 EIF4A1

CTD Gene:1973 EIF4A1

dbSNP Gene:1973 EIF4A1

ENSEMBL:ENSG00000161960 EIF4A1

HGNC:3282 EIF4A1

KEGG:hsa:1973 EIF4A1

Monarch:1973 EIF4A1

NCBI Gene:1973 EIF4A1

OMIM:602641 EIF4A1

UCSC:P60842 EIF4A1

Reference Transcript

Participates

as a component of

eIF4A subunits complex [cytosol] (Homo sapiens)

as a member of

eIF4A [cytosol] (Homo sapiens)

Inferred To

inf-1 [cytosol] (Caenorhabditis elegans)

Eif4a1 [cytosol] (Mus musculus)

Eif4a1 [cytosol] (Rattus norvegicus)

EIF4A1 [cytosol] (Bos taurus)

EIF4A1 [cytosol] (Canis familiaris)

EIF4A1 [cytosol] (Plasmodium falciparum)

EIF4A1 [cytosol] (Sus scrofa)

eif4a1b [cytosol] (Danio rerio)

Ghost homologue of EIF4A1 [cytosol] (Gallus gallus)

Ghost homologue of EIF4A1 [cytosol] (Xenopus tropicalis)

ifdA [cytosol] (Dictyostelium discoideum)

eIF4A [cytosol] (Drosophila melanogaster)

tif1 [cytosol] (Schizosaccharomyces pombe)

TIF1; TIF2 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001407.1, NP_001191439.1

OpenTargets

ENSG00000161960

ENSEMBL

ENSP00000293831, ENST00000577269, ENST00000293831, ENSG00000161960, ENSP00000463486

ZINC - Substances

IF4A1_HUMAN

ZINC - Biogenic

IF4A1_HUMAN

ZINC target

P60842

PRO

P60842

GlyGen

P60842

PDB

7PQ0, 3EIQ, 8HUJ, 8XXN, 9DTS, 6ZMW, 2G9N, 7PPZ, 9AVR, 8OZ0, 5ZBZ, 9BLN, 5ZC9, 2ZU6

HPA

ENSG00000161960-EIF4A1

GeneCards

EIF4A1

Pharos - Targets

P60842

ZINC - Predictions - Purchasable

IF4A1_HUMAN

HMDB Protein

HMDBP11793

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04637 EIF4G1	2	EIF4G1 [cytosol] (R-HSA-72584) p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762)	0.966	18
UniProt:Q53EL6 PDCD4	1	PDCD4 [cytosol] (R-HSA-5432887)	0.955	12
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.848	6
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.569	10
UniProt:Q15056 EIF4H	1	EIF4H [cytosol] (R-HSA-72591)	0.544	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.527	3
UniProt:P38919 EIF4A3	2	EIF4A3 [cytosol] (R-HSA-927868) EIF4A3 [nucleoplasm] (R-HSA-8849149)	0.527	2

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