Reactome | SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]

SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]

Stable Identifier

R-HSA-5334830

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Retinoic acid receptor alpha, RARA_HUMAN

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Literature References

PubMed ID	Title	Journal	Year
19850744	Small ubiquitin-like modifier-2 modification of retinoic acid receptor-alpha regulates its subcellular localization and transcriptional activity Santos, NC, Zhu, L, Kim, KH	Endocrinology	2009

External Reference Information

External Reference

UniProt:P10276 RARA

Gene Names

RARA, NR1B1

Chain

chain:1-462

Reference Genes

BioGPS Gene:5914 RARA

COSMIC (genes):RARA RARA

CTD Gene:5914 RARA

dbSNP Gene:5914 RARA

ENSEMBL:ENSG00000131759 RARA

ENSEMBL_homo_sapiens_GENE:ENSG00000131759.18 RARA

HGNC:9864 RARA

KEGG Gene (Homo sapiens):5914 RARA

Monarch:5914 RARA

NCBI Gene:5914 RARA

OMIM:180240 RARA

UCSC:P10276 RARA

Reference Transcript

Other Identifiers

11722900_s_at

11722901_a_at

11727350_x_at

11727351_a_at

11727352_x_at

11736235_x_at

11736236_s_at

11750414_s_at

11751510_s_at

1337_s_at

1565358_PM_at

1565358_at

16834071

203749_PM_s_at

203749_s_at

203750_PM_s_at

203750_s_at

211605_PM_s_at

211605_s_at

216300_PM_x_at

216300_x_at

3720922

3720924

3720929

3720930

3720935

3720936

3720937

3720945

3720946

3720948

3720949

3720950

3720951

3720952

3720953

3720954

3720955

3720956

3720957

3720958

3720959

3720960

3720961

5914

8007084

A_23_P207842

A_32_P5251

GE79425

GO:0000122

GO:0000785

GO:0000900

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0001217

GO:0001223

GO:0001657

GO:0001843

GO:0001889

GO:0001972

GO:0002068

GO:0002376

GO:0003417

GO:0003677

GO:0003682

GO:0003700

GO:0003723

GO:0004879

GO:0005102

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005730

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0007155

GO:0007281

GO:0007565

GO:0008092

GO:0008270

GO:0008284

GO:0008285

GO:0008289

GO:0008584

GO:0009755

GO:0010628

GO:0010629

GO:0012501

GO:0015629

GO:0016071

GO:0016192

GO:0017148

GO:0019899

GO:0019904

GO:0021766

GO:0022414

GO:0023052

GO:0030154

GO:0030425

GO:0030850

GO:0030852

GO:0030853

GO:0031076

GO:0031490

GO:0031641

GO:0032355

GO:0032526

GO:0032689

GO:0032720

GO:0032736

GO:0032753

GO:0032754

GO:0032991

GO:0033189

GO:0034097

GO:0035264

GO:0036211

GO:0042789

GO:0042826

GO:0042981

GO:0043226

GO:0043277

GO:0043422

GO:0043565

GO:0044323

GO:0045182

GO:0045471

GO:0045596

GO:0045630

GO:0045666

GO:0045787

GO:0045892

GO:0045893

GO:0045944

GO:0046872

GO:0048027

GO:0048167

GO:0048384

GO:0048471

GO:0048856

GO:0051018

GO:0051099

GO:0051393

GO:0055012

GO:0060010

GO:0060089

GO:0060173

GO:0060324

GO:0060348

GO:0060534

GO:0060591

GO:0061037

GO:0071222

GO:0071300

GO:0071391

GO:0090575

GO:0140110

GO:1901363

GO:1901532

GO:1902894

GO:1990837

HMNXSV003003758

Hs.250505.0.A1_3p_s_at

Hs2.433206.2.S1_3p_at

ILMN_1659206

ILMN_1677197

ILMN_1716176

ILMN_1791902

PH_hs_0017352

TC17000496.hg

X06614_at

g4506418_3p_a_at

Participates

as a component of

RARA:RXRA [nucleoplasm] (Homo sapiens)

Other forms of this molecule

polySUMO2-K166,K171,K399-RARA [nucleoplasm]

RARA [nucleoplasm]

Inferred To

Homologues of SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (Caenorhabditis elegans)

phospho-Rara [nucleoplasm] (Rattus norvegicus)

phospho-nhr-85 [nucleoplasm] (Caenorhabditis elegans)

phospho-unc-55 [nucleoplasm] (Caenorhabditis elegans)

phospho-sex-1 [nucleoplasm] (Caenorhabditis elegans)

phospho-nhr-2 [nucleoplasm] (Caenorhabditis elegans)

phospho-Eip75B [nucleoplasm] (Drosophila melanogaster)

phospho-SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (Mus musculus)

phospho-RARA [nucleoplasm] (Bos taurus)

phospho-RARA [nucleoplasm] (Canis familiaris)

phospho-RARA [nucleoplasm] (Gallus gallus)

phospho-RARA [nucleoplasm] (Sus scrofa)

phospho-nhr-7 [nucleoplasm] (Caenorhabditis elegans)

phospho-raraa [nucleoplasm] (Danio rerio)

Modified Residues

Name

sumoylated lysine (polySUMO2 [nucleoplasm]) at 166

Coordinate

166

Modification

polySUMO2 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (polySUMO2 [nucleoplasm]) at 171

Coordinate

171

Modification

polySUMO2 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

sumoylated lysine (polySUMO2 [nucleoplasm]) at 399

Coordinate

399

Modification

polySUMO2 [nucleoplasm]

PsiMod Name

sumoylated lysine

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.

Name

O-phospho-L-serine at 219

Coordinate

219

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 369

Coordinate

369

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_005257610.1, XP_005257611.1, XP_011523397.1, NP_001138774.1, NP_001019980.1, NP_001138773.1, NP_000955.1

ZINC - World Drugs

RARA_HUMAN

Guide to Pharmacology - Targets

590

OpenTargets

ENSG00000131759

ZINC - FDA approved

RARA_HUMAN

ZINC - Substances

RARA_HUMAN

ZINC target

P10276

ZINC - Biogenic

RARA_HUMAN

PRO

P10276

PDB

3A9E, 5K13, 7AOS, 6XWG, 7APO, 7WQQ, 4DQM, 3KMR, 3KMZ, 1DKF, 7QAA, 1DSZ

ZINC - Investigational

RARA_HUMAN

ZINC - Metabolites

RARA_HUMAN

HPA

ENSG00000131759-RARA

GeneCards

P10276

Ensembl

ENSG00000131759, ENST00000394081, ENSP00000377649, ENST00000254066, ENSP00000377643, ENSP00000254066, ENST00000425707, ENST00000394089, ENSP00000389993

Pharos - Targets

P10276

Orphanet

15188

ZINC - Predictions - Purchasable

RARA_HUMAN

HMDB Protein

HMDBP01910

Interactors (42)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19793 RXRA	4	RXRA [cytosol] (R-HSA-9619757) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) RXRA [nucleoplasm] (R-HSA-381319)	0.951	15
UniProt:P28702 RXRB	1	RXRB [nucleoplasm] (R-HSA-446163)	0.949	16
UniProt:P48443 RXRG	1	RXRG [nucleoplasm] (R-HSA-446170)	0.944	18
UniProt:Q15788 NCOA1	3	monoSUMO1-K732,K774-NCOA1 [nucleoplasm] (R-HSA-4085291) NCOA1 (868-1441) [nucleoplasm] (R-HSA-5603230) NCOA1 [nucleoplasm] (R-HSA-442496)	0.869	7
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.818	6
UniProt:O75376 NCOR1	2	NCOR1 [cytosol] (R-HSA-1253310) NCOR1 [nucleoplasm] (R-HSA-442501)	0.802	6
UniProt:P48552 NRIP1	2	monoSUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057) NRIP1 [nucleoplasm] (R-HSA-4086031)	0.666	4
UniProt:Q8WW24 TEKT4			0.666	4
UniProt:Q91XC0 Ajuba	3	Ajuba [nucleoplasm] (R-MMU-5687969) phospho-Ajuba [cytosol] (R-MMU-2574841) Ajuba [cytosol] (R-MMU-2564698)	0.653	7
UniProt:Q9Y618 NCOR2	2	monoSUMO1-K672-NCOR2 [nucleoplasm] (R-HSA-3927904) NCOR2 [nucleoplasm] (R-HSA-442469)	0.647	4
UniProt:P59598	1	Asxl1 [nucleoplasm] (R-MMU-5689645)	0.61	4
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.597	4
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.577	3
UniProt:Q9Y6Q9 NCOA3	2	NCOA3 [nucleoplasm] (R-HSA-442488) p-S857 NCOA3 [nucleoplasm] (R-HSA-5687005)	0.564	2
UniProt:P50148 GNAQ	1	GNAQ [plasma membrane] (R-HSA-55453)	0.563	4
UniProt:O15296 ALOX15B	1	ALOX15B [cytosol] (R-HSA-2142725)	0.556	3
UniProt:Q15699 ALX1			0.556	3
UniProt:O95273 CCDB1			0.556	3
UniProt:P13056-2 P130562			0.556	3
UniProt:P63165 SUMO1	11	lysyl-G97-SUMO1 [plasma membrane] (R-HSA-9762382) lysyl-G97-SUMO1 [nucleolus] (R-HSA-9762385) lysyl-G97-SUMO1 [viral capsid] (R-HSA-9762386) UBE2I-G97-SUMO1 [cytosol] (R-HSA-4656941) lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9762380) lysyl-G97-SUMO1 [cytosol] (R-HSA-9762266) UBE2I-G97-SUMO1 [nucleoplasm] (R-HSA-3730622) UBA2-G97-SUMO1 [nucleoplasm] (R-HSA-3730616) SUMO1 [nucleoplasm] (R-HSA-877304) SUMO1(2-101) [nucleoplasm] (R-HSA-2990831) lysyl-G97-SUMO1 [nucleoplasm] (R-HSA-9761562)	0.556	5
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:P28702-3 RXRB			0.556	3
UniProt:Q96RK4 BBS4	1	BBS4 [cytosol] (R-HSA-5617635)	0.556	3
UniProt:P37231 PPARG	2	monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444) PPARG [nucleoplasm] (R-HSA-446172)	0.556	3
UniProt:P51946 CCNH	1	CCNH [nucleoplasm] (R-HSA-69220)	0.544	2
UniProt:Q92754 TFAP2C	3	monoSUMO1-K10-TFAP2C [nucleoplasm] (R-HSA-3234071) TFAP2C [cytosol] (R-HSA-8864579) TFAP2C [nucleoplasm] (R-HSA-3234058)	0.532	4
UniProt:P42224 STAT1	8	p-STAT1 [nucleoplasm] (R-HSA-8987140) p-STAT1 [cytosol] (R-HSA-8950418) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622)	0.532	4
UniProt:P55317 FOXA1	1	FOXA1 [nucleoplasm] (R-HSA-453074)	0.532	4
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.532	5
UniProt:P13631 RARG	1	RARG [nucleoplasm] (R-HSA-446161)	0.527	2
UniProt:O43707-1 ACTN4			0.524	2
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.524	3
UniProt:Q2M1K9 ZNF423	1	ZNF423 [nucleoplasm] (R-HSA-3222318)	0.524	2
UniProt:Q16236 NFE2L2	13	p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-NFE2L2 [cytosol] (R-HSA-9758077) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109)	0.524	2
UniProt:Q71SY5 MED25	1	MED25 [nucleoplasm] (R-HSA-212414)	0.508	10
UniProt:P78527 PRKDC	4	K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [cytosol] (R-HSA-3134816) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302) PRKDC [nucleoplasm] (R-HSA-62161)	0.499	3
UniProt:Q9UKP3 ITBP2			0.499	2
UniProt:Q9UPP1-2 PHF8	2	p-S33,84-PHF8-2 [nucleoplasm] (R-HSA-2245220) PHF8-2 [nucleoplasm] (R-HSA-2245222)	0.499	2
UniProt:O75376-2 NCOR1			0.488	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.463	2
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.462	3

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