Reactome | CCNT1 [nucleoplasm]

CCNT1 [nucleoplasm]

Stable Identifier

R-HSA-51611

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Cyclin T1, Cyclin T, CycT1

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Nuclear Receptors (Homo sapiens)
  - ESR-mediated signaling (Homo sapiens)
    - Estrogen-dependent gene expression (Homo sapiens)
      - ESR1:ESTG:P-TEFb recruited to paused RNA polymerase II on MYB gene (Homo sapiens)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Homo sapiens)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Homo sapiens)
        
        CCNT1 [nucleoplasm] (Homo sapiens)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Homo sapiens)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Homo sapiens)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Homo sapiens)
        
        CCNT1 [nucleoplasm] (Homo sapiens)
      - Estrogen-responsive MYB gene expression (Homo sapiens)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Homo sapiens)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Homo sapiens)
        
        CCNT1 [nucleoplasm] (Homo sapiens)
        
        MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Homo sapiens)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Homo sapiens)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Homo sapiens)
        
        CCNT1 [nucleoplasm] (Homo sapiens)
      - p-TEFb phosphorylates serine 2 in RNA polymerase II CTD (Homo sapiens)
        
        MYB gene:hyperphosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Homo sapiens)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Homo sapiens)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Homo sapiens)
        
        CCNT1 [nucleoplasm] (Homo sapiens)
        
        MYB gene:hypophosphorylated RNA polymerase II:TFIIF:ESR1:ESTG:P-TEFb [nucleoplasm] (Homo sapiens)
        
        ESR1:ESTG:P-TEFb [nucleoplasm] (Homo sapiens)
        
        P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Homo sapiens)
        
        CCNT1 [nucleoplasm] (Homo sapiens)
- Signaling by TGFB family members (Homo sapiens)
  - Signaling by TGF-beta Receptor Complex (Homo sapiens)
    - Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Homo sapiens)
      - SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Homo sapiens)
        
        Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Homo sapiens)
        
        CDK8:CCNC/ CDK9:CCNT [nucleoplasm] (Homo sapiens)
        
        P-TEFb complex [nucleoplasm] (Homo sapiens)
        
        CCNT1,CCNT2,CCNK [nucleoplasm] (Homo sapiens)
        
        CCNT1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60563 CCNT1

Gene Names

CCNT1

Chain

chain:1-726

Reference Genes

BioGPS Gene:904 CCNT1

COSMIC (genes):CCNT1 CCNT1

CTD Gene:904 CCNT1

dbSNP Gene:904 CCNT1

ENSEMBL:ENSG00000129315 CCNT1

HGNC:1599 CCNT1

KEGG:hsa:904 CCNT1

Monarch:904 CCNT1

NCBI Gene:904 CCNT1

OMIM:143055 CCNT1

UCSC:O60563 CCNT1

Reference Transcript

Other Identifiers

11740231_a_at

16763970

206967_PM_at

206967_at

225493_PM_at

225493_at

3453215

3453216

3453217

3453219

3453220

3453222

3453223

3453224

3453225

3453226

3453227

3453229

3453230

3453231

3453232

3453233

3453234

3453237

3453238

3453242

3453243

36391_at

3720861

44701_at

7962831

904

A_23_P87575

A_23_P98963

A_24_P136415

GE56015

GE62659

GO:0000079

GO:0000307

GO:0000976

GO:0003677

GO:0003682

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0008024

GO:0009410

GO:0016538

GO:0017069

GO:0019901

GO:0032786

GO:0032968

GO:0043226

GO:0043923

GO:0045944

GO:0051301

GO:0060090

GO:0061575

GO:0070063

GO:0070691

GO:0097322

GO:0098772

GO:0140297

GO:0140693

HMNXSV003021496

Hs.92308.0.S1_3p_at

ILMN_1692390

ILMN_1817255

PH_hs_0005116

PH_hs_0014426

TC12001456.hg

TC12002862.hg

g4502626_3p_at

Participates

as an input of

Formation of the P-TEFb(Cyclin T1:Cdk9) complex (Homo sapiens)

as a component of

P-TEFb(Cyclin T1:Cdk9) complex [nucleoplasm] (Homo sapiens)

as a member of

CCNT1,CCNT2,CCNK [nucleoplasm] (Homo sapiens)

Inferred To

lsc1 [nucleoplasm] (Schizosaccharomyces pombe)

Ccnt1 [nucleoplasm] (Mus musculus)

Ccnt1 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of CCNT1 [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of CCNT1 [nucleoplasm] (Xenopus tropicalis)

cit-1.2 [nucleoplasm] (Caenorhabditis elegans)

pch1 [nucleoplasm] (Schizosaccharomyces pombe)

CCNT1 [nucleoplasm] (Bos taurus)

CCNT1 [nucleoplasm] (Canis familiaris)

CCNT1 [nucleoplasm] (Gallus gallus)

CCNT1 [nucleoplasm] (Sus scrofa)

cit-1.1 [nucleoplasm] (Caenorhabditis elegans)

BUR2 [nucleoplasm] (Saccharomyces cerevisiae)

cycK [nucleoplasm] (Dictyostelium discoideum)

CTK2 [nucleoplasm] (Saccharomyces cerevisiae)

CycT [nucleoplasm] (Drosophila melanogaster)

Homologues of CCNT1 [nucleoplasm] (Caenorhabditis elegans)

Homologues of CCNT1 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of CCNT1 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_001231.2, NP_001264771.1

OpenTargets

ENSG00000129315

ENSEMBL

ENSP00000399845, ENST00000618666, ENST00000261900, ENST00000417344, ENSP00000261900, ENSP00000481035

HPA

ENSG00000129315-CCNT1

ZINC - Substances

CCNT1_HUMAN

ZINC target

O60563

PRO

O60563

Pharos - Targets

O60563

GlyGen

O60563

ZINC - Predictions - Purchasable

CCNT1_HUMAN

PDB

6CYT, 2PK2, 3MY1, 4BCG, 4EC8, 4BCF, 3TNI, 6Z45, 3BLQ, 3BLH, 3TN8, 4EC9, 4BCH, 3TNH, 3BLR, 4OR5, 4BCJ, 4IMY, 4BCI, 3LQ5, 5L1Z, 7NWK, 8I0L, 3MI9, 4OGR, 6GZH, 6W9E, 3MIA, 8K5R

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P50750 CDK9	1	CDK9 [nucleoplasm] (R-HSA-51801)	0.977	31
UniProt:O94992 HEXI1			0.904	13
UniProt:Q9UHB7 AFF4	1	AFF4 [nucleoplasm] (R-HSA-8932788)	0.81	8
UniProt:Q4G0J3 LARP7			0.802	9
UniProt:P04608 tat	1	Tat (P04608) [nucleoplasm] (R-HIV-175856)	0.78	9
UniProt:P48426 PIP4K2A	2	PIP4K2A [cytosol] (R-HSA-1604641) PIP4K2A [nucleoplasm] (R-HSA-6811484)	0.643	3
UniProt:O60885-1 BRD4			0.544	6
UniProt:O12161 MINT-5231871			0.544	2
UniProt:P04326 TAT			0.536	2
UniProt:P51825 AFF1			0.532	8
UniProt:Q9Y698 CACNG2	2	CACNG2 [plasma membrane] (R-HSA-210375) CACNG2 [endocytic vesicle membrane] (R-HSA-416846)	0.527	2
UniProt:Q9P0M6 H2AW			0.527	2
UniProt:Q00534 CDK6	3	p-T177-CDK6 [nucleoplasm] (R-HSA-69628) CDK6 [nucleoplasm] (R-HSA-141283) CDK6 [cytosol] (R-HSA-68336)	0.527	4
UniProt:Q8WXF1 PSPC1			0.527	2
UniProt:Q6PD62 CTR9	1	CTR9 [nucleoplasm] (R-HSA-8866694)	0.527	2
UniProt:Q86VU5 CMTD1			0.527	2
IntAct:EBI-2890930 MLL			0.527	2
UniProt:Q9HB65 ELL3	1	ELL3 [nucleoplasm] (R-HSA-6807497)	0.527	3
UniProt:Q86TG1 T150A			0.527	2
UniProt:Q03111 MLLT1	1	MLLT1 [nucleoplasm] (R-HSA-8932918)	0.527	3
UniProt:Q96MH2 HEXI2			0.527	3
UniProt:P04610 TAT			0.499	2
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.483	2
UniProt:Q8WUA2 PPIL4	1	PPIL4 [nucleoplasm] (R-HSA-8952113)	0.483	2
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.462	2

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