Reactome | RPL13A [cytosol]

RPL13A [cytosol]

Stable Identifier

R-HSA-72412

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

60S ribosomal protein L13a, 23 kDa highly basic protein

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        Viral mRNA Translation (Homo sapiens)
        
        Synthesis of PB1-F2 (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
        
        Viral Protein Synthesis (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL13A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P40429 RPL13A

Gene Names

RPL13A

Chain

initiator methionine:, chain:2-203

Reference Genes

BioGPS Gene:23521 RPL13A

COSMIC (genes):RPL13A RPL13A

CTD Gene:23521 RPL13A

dbSNP Gene:23521 RPL13A

ENSEMBL:ENSG00000142541 RPL13A

ENSEMBL_homo_sapiens_GENE:ENSG00000142541.18 RPL13A

HGNC:10304 RPL13A

KEGG Gene (Homo sapiens):23521 RPL13A

Monarch:23521 RPL13A

NCBI Gene:23521 RPL13A

OMIM:619225 RPL13A

UCSC:P40429 RPL13A

Reference Transcript

Other Identifiers

11755250_x_at

11757331_x_at

11757385_x_at

16707927

200715_PM_x_at

200715_x_at

200716_PM_x_at

200716_x_at

210646_PM_x_at

210646_x_at

211942_3p_x_at

211942_PM_x_at

211942_x_at

212790_PM_x_at

212790_x_at

23521

2865361

3017977

3141962

3259616

3259619

3405583

3449689

3449690

35119_at

3515420

3515421

3537038

3562984

3838576

3838579

3838585

3838587

3838588

3838591

3838595

3838599

3838600

3838602

3838603

3838604

3916472

3916474

3916475

3957510

8030351

A_23_P90143

GE81797

GO:0002181

GO:0002376

GO:0003723

GO:0003729

GO:0003735

GO:0005198

GO:0005634

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0005925

GO:0006412

GO:0006417

GO:0015934

GO:0016020

GO:0017148

GO:0022625

GO:0022626

GO:0032496

GO:0042592

GO:0043226

GO:0045202

GO:0048246

GO:0048856

GO:0048870

GO:0060425

GO:0065003

GO:0071346

GO:0097452

GO:0098542

GO:1901194

GO:1990904

HMNXSV003026143

ILMN_1713369

PH_hs_0030383

PH_hs_0033702

TC19002198.hg

X56932_at

g12653484_3p_s_at

g12804528_3p_x_at

Participates

as an input of

INF-gamma induced phosphorylation of L13a (Homo sapiens)

as an output of

Dissociation of L13a from the 60s ribosomal subunit (Homo sapiens)

as a component of

60S ribosomal complex [cytosol] (Homo sapiens)

Other forms of this molecule

p-RPL13A [cytosol]

Inferred To

rpl1601 [cytosol] (Schizosaccharomyces pombe)

Homologues of RPL13A [cytosol] (Schizosaccharomyces pombe)

Ghost homologue of RPL13A [cytosol] (Gallus gallus)

rpl-16 [cytosol] (Caenorhabditis elegans)

rpl13a [cytosol] (Danio rerio)

rpl13a [cytosol] (Dictyostelium discoideum)

rpl13a [cytosol] (Xenopus tropicalis)

RPL16A [cytosol] (Saccharomyces cerevisiae)

RPL13A [cytosol] (Bos taurus)

RPL13A [cytosol] (Canis familiaris)

RPL13A [cytosol] (Plasmodium falciparum)

RPL13A [cytosol] (Sus scrofa)

rpl1602 [cytosol] (Schizosaccharomyces pombe)

Rpl13a [cytosol] (Mus musculus)

Rpl13a [cytosol] (Rattus norvegicus)

RpL13A [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_036555.1, NP_001257420.1

OpenTargets

ENSG00000142541

GeneCards

P40429

HPA

ENSG00000142541-RPL13A

Ensembl

ENSP00000375730, ENSG00000142541, ENST00000391857

PRO

P40429

Pharos - Targets

P40429

PDB

8INF, 8FKQ, 8INE, 8G5Z, 6OLZ, 5AJ0, 6Y0G, 8Y0X, 8IFD, 6OM7, 6IP6, 8FKR, 6IP5, 8IFE, 8G60, 8IDT, 8IPY, 8FL6, 7XNY, 6ZME, 8FL7, 8IPX, 6OM0, 7XNX, 6ZM7, 8FKU, 8GLP, 6Y6X, 6LSR, 6OLG, 8FL4, 6OLI, 8JDM, 8FKV, 8JDL, 4UG0, 8FKS, 6OLF, 6LQM, 6OLE, 8FL3, 8JDK, 8FL2, 8JDJ, 8OJ0, 6IP8, 8FKT, 8IPD, 8IDY, 7BHP, 6ZMI, 8FLA, 7F5S, 8FL0, 8QFD, 8FL9, 6ZMO, 8G5Y, 6Y2L, 8FKZ, 6LU8, 8FKY, 8IE3, 8FKP, 8Y0W, 6Z6N, 6W6L, 8FKX, 6QZP, 8A3D, 8FLF, 8FKW, 6Z6M, 8FLE, 8OHD, 8OJ8, 6Z6L, 8G6J, 6XA1, 8OJ5, 6LSS, 4V6X, 8FLD, 7QVP, 8FLC, 8IR1, 8IR3, 5T2C, 8INK, 5LKS, 6Y57, 8G61, 8FLB, 7OW7

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49711 CTCF	1	CTCF [nucleoplasm] (R-HSA-3782562)	0.643	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P62888 RPL30	1	RPL30 [cytosol] (R-HSA-72452)	0.547	2
UniProt:P06428 VE6			0.547	2
UniProt:Q15050 RRS1			0.527	3
UniProt:Q15397 PUM3			0.527	3
UniProt:P36578 RPL4	1	RPL4 [cytosol] (R-HSA-72474)	0.527	3
UniProt:P42696 RBM34			0.527	3
UniProt:Q15020 SART3			0.527	3
UniProt:Q9UHB9 SRP68	1	SRP68 [cytosol] (R-HSA-445234)	0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	6
UniProt:P84098 RPL19	1	RPL19 [cytosol] (R-HSA-72424)	0.527	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.527	2
UniProt:O75607 NPM3			0.527	2
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.527	2
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.527	3
UniProt:Q14684 RRP1B			0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q12906 ILF3	3	p-T188,T315-ILF3 [cytosol] (R-HSA-9836381) ILF3 [cytosol] (R-HSA-450564) ILF3 [nucleoplasm] (R-HSA-9760401)	0.527	2
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	2
UniProt:P62753 RPS6	4	RPS6 [nucleoplasm] (R-HSA-6790606) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) p-5S-RPS6 [cytosol] (R-HSA-165727) RPS6 [cytosol] (R-HSA-72381)	0.483	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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