Reactome | apoTF [clathrin-coated endocytic vesicle membrane]

apoTF [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-8869140

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

Serotransferrin

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02787 TF

Gene Names

TF, PRO1400

Chain

signal peptide:1-19, chain:20-698

Reference Genes

BioGPS Gene:7018 TF

COSMIC (genes):TF TF

CTD Gene:7018 TF

dbSNP Gene:7018 TF

ENSEMBL:ENSG00000091513 TF

HGNC:11740 TF

KEGG:hsa:7018 TF

Monarch:7018 TF

NCBI Gene:7018 TF

OMIM:190000 TF

UCSC:P02787 TF

Reference Transcript

Participates

as a component of

holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

TF [endoplasmic reticulum lumen]

p-TF [endoplasmic reticulum lumen]

apoTF [extracellular region]

apoTF [endosome membrane]

TF [secretory granule lumen]

Inferred To

TF [clathrin-coated endocytic vesicle membrane] (Bos taurus)

TF [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

Tf [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Tf [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

apoTF [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

Cross References

RefSeq

XP_016862579.1, XP_016862578.1, NP_001054.1, NP_001054.2

OpenTargets

ENSG00000091513

ENSEMBL

ENST00000402696, ENSG00000091513, ENSP00000385834

ZINC - Substances

TRFE_HUMAN

ZINC target

P02787

PRO

P02787

GlyGen

P02787

PDB

1N7X, 6D04, 3V8X, 1OQH, 6D03, 4X1D, 5WTD, 5X5P, 3S9N, 4H0W, 1DTG, 1A8E, 1SUV, 2HAU, 1JQF, 1RYO, 3SKP, 2HAV, 5H52, 3QYT, 6SOY, 2O84, 7FFU, 1N84, 1N7W, 5DYH, 6D05, 1OQG, 1BP5, 6UJ6, 4X1B, 8BRC, 3S9L, 3VE1, 3V89, 3S9M, 1BTJ, 1A8F, 1B3E, 7Q1L, 3V83, 6SOZ, 1D4N, 1FQE, 5Y6K, 1FQF, 1D3K, 6JAS, 6CTC, 3FGS, 7FFM, 2O7U

GeneCards

HPA

ENSG00000091513-TF

Pharos - Targets

P02787

Orphanet

HMDB Protein

HMDBP02076

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02786 TFRC	5	TFRC(1-760) [plasma membrane] (R-HSA-917983) TFRC(1-760) [endosome membrane] (R-HSA-8961829) TFRC(1-760) [cytoplasmic vesicle membrane] (R-HSA-434196) TFRC(1-760) [Golgi membrane] (R-HSA-434330) TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869124)	0.852	7
UniProt:A5K736 A5K736			0.733	9
UniProt:Q9K0U9 TBPA			0.632	4
UniProt:Q09057 TBPB1			0.618	3
UniProt:Q9K0V0 TBPB			0.558	2
UniProt:O15173 PGRMC2	4	PGRMC2 [nuclear envelope] (R-HSA-9707674) PGRMC2 [nucleoplasm] (R-HSA-9707859) PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.556	3
UniProt:O43278-2 SPINT1			0.556	3
UniProt:Q8N9I0 SYT2	3	SYT2 [synaptic vesicle membrane] (R-HSA-194786) SYT2 [plasma membrane] (R-HSA-168795) SYT2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869116)	0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
UniProt:Q7Z7G2 CPLX4			0.556	3
UniProt:Q96TC7 RMD3			0.556	3
UniProt:O00501 CLDN5	2	CLDN5 [cell junction] (R-HSA-421264) CLDN5 [plasma membrane] (R-HSA-419991)	0.556	3
UniProt:Q4KMG9 TM52B			0.556	3
UniProt:Q99523 SORT1	2	SORT1 [cytoplasmic vesicle membrane] (R-HSA-434221) SORT1 [Golgi membrane] (R-HSA-434332)	0.556	3
UniProt:P08034 GJB1	2	GJB1 [endoplasmic reticulum membrane] (R-HSA-190656) GJB1 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190636)	0.556	3
UniProt:Q8TED1 GPX8	1	GPX8 [endoplasmic reticulum lumen] (R-HSA-3341303)	0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q8NBJ4 GOLM1	2	p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938) GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710)	0.556	3
UniProt:O15529 GPR42			0.556	3
UniProt:A8MZ59 LEUTX	1	LEUTX [nucleoplasm] (R-HSA-9817277)	0.556	3
UniProt:O43315 AQP9	1	AQP9 [plasma membrane] (R-HSA-431761)	0.556	3
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.556	3
UniProt:Q96KR6 F210B			0.556	3
UniProt:Q9BXS9-3 SLC26A6			0.556	3
UniProt:Q9NQZ2 UTP3	1	UTP3 [nucleoplasm] (R-HSA-6790637)	0.527	2
UniProt:Q16659 MAPK6 gene	6	p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) MAPK6 [nucleoplasm] (R-HSA-5692686) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) p-S189 MAPK6 [cytosol] (R-HSA-5687019) MAPK6 [cytosol] (R-HSA-5686979) ub-MAPK6 [cytosol] (R-HSA-5687000)	0.527	2
UniProt:O15232 MATN3	3	MATN3 [extracellular region] (R-HSA-2426297) p-MATN3 [endoplasmic reticulum lumen] (R-HSA-8957026) MATN3 [endoplasmic reticulum lumen] (R-HSA-8956719)	0.527	2
UniProt:Q9H8H2 DDX31			0.527	2
UniProt:Q9H788 SH24A			0.527	2
UniProt:P35219 CAH8			0.527	2
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.527	6
UniProt:Q8N412 STPG2			0.527	2
UniProt:Q9BSW7 SYT17			0.527	2
UniProt:P05091 ALDH2	1	ALDH2 [mitochondrial matrix] (R-HSA-71718)	0.527	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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