Reactome | apoTF [clathrin-coated endocytic vesicle membrane]

apoTF [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-8869140

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

Serotransferrin

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P02787 TF

Gene Names

TF, PRO1400

Chain

signal peptide:1-19, chain:20-698

Reference Genes

BioGPS Gene:7018 TF

COSMIC (genes):TF TF

CTD Gene:7018 TF

dbSNP Gene:7018 TF

ENSEMBL:ENSG00000091513 TF

HGNC:11740 TF

KEGG Gene (Homo sapiens):7018 TF

Monarch:7018 TF

NCBI Gene:7018 TF

OMIM:190000 TF

UCSC:P02787 TF

Reference Transcript

Other Identifiers

0005670739

11719658_a_at

11751529_a_at

11756783_a_at

16945870

16945907

203400_s_at

214063_s_at

2555254

2643236

2643237

2643240

2643241

2643243

2643244

2643248

2643249

2643251

2643252

2643254

2643257

2643264

2643265

2643267

2643268

2643271

2643273

2643274

2643275

2643277

2643279

2643280

2643281

2643282

2643283

2643284

2643285

2643286

2643287

2643288

2643289

2643290

2643291

2643292

2643293

2643294

2643321

2643323

2643325

2643326

2643327

2643328

2643329

2643330

2643331

2643332

32538_at

7018

8082797

8082816

A_14_P129777

A_23_P212500

A_23_P212508

GE58831

GO:0001895

GO:0002376

GO:0002576

GO:0003674

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005768

GO:0005769

GO:0005770

GO:0005783

GO:0005788

GO:0005886

GO:0005905

GO:0006464

GO:0006810

GO:0006811

GO:0006826

GO:0006879

GO:0006950

GO:0007010

GO:0007015

GO:0007165

GO:0007257

GO:0008150

GO:0008198

GO:0008199

GO:0009058

GO:0009617

GO:0009925

GO:0009986

GO:0010008

GO:0015031

GO:0016020

GO:0016192

GO:0016324

GO:0019731

GO:0030139

GO:0030154

GO:0030316

GO:0030669

GO:0031232

GO:0031410

GO:0031647

GO:0031982

GO:0032991

GO:0033572

GO:0034641

GO:0034756

GO:0034774

GO:0034986

GO:0040011

GO:0042327

GO:0042592

GO:0043167

GO:0043226

GO:0043687

GO:0044267

GO:0045178

GO:0045780

GO:0045893

GO:0046872

GO:0048260

GO:0048471

GO:0048856

GO:0048870

GO:0055037

GO:0055072

GO:0060395

GO:0061024

GO:0070062

GO:0070371

GO:0071281

GO:0072562

GO:1990459

GO:1990712

GO:2000147

HMNXSV003052276

ILMN_1768425

PH_hs_0025298

S95936_at

g4557870_3p_s_at

Participates

as a component of

holoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

TF [secretory granule lumen]

apoTF [endosome membrane]

apoTF [extracellular region]

p-TF [endoplasmic reticulum lumen]

TF [endoplasmic reticulum lumen]

Inferred To

TF [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

Tf [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Tf [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

tfa [clathrin-coated endocytic vesicle membrane] (Danio rerio)

Cross References

RefSeq

XP_016862578.1, NP_001054.1, XP_016862579.1

OpenTargets

ENSG00000091513

HPA

ENSG00000091513-TF

GeneCards

P02787

ZINC target

P02787

Ensembl

ENSG00000091513, ENSP00000385834, ENST00000402696

PRO

P02787

Pharos - Targets

P02787

GlyGen

P02787

Orphanet

15600

HMDB Protein

HMDBP02076

PDB

3VE1, 6JAS, 5Y6K, 3S9L, 1BP5, 2O84, 2O7U, 3S9M, 3SKP, 4H0W, 6SOY, 6SOZ, 1DTG, 1N7X, 5H52, 3V89, 1JQF, 1SUV, 2HAV, 6CTC, 1D3K, 2HAU, 6UJ6, 1N84, 3V83, 4X1D, 1FQE, 1BTJ, 5X5P, 1RYO, 1FQF, 6D05, 1N7W, 3FGS, 4X1B, 1OQH, 3QYT, 1A8E, 3V8X, 1A8F, 5WTD, 1B3E, 5DYH, 6D04, 1OQG, 3S9N, 6D03, 1D4N

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02786 TFRC	5	TFRC(1-760) [Golgi membrane] (R-HSA-434330) TFRC(1-760) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869124) TFRC(1-760) [cytoplasmic vesicle membrane] (R-HSA-434196) TFRC(1-760) [endosome membrane] (R-HSA-8961829) TFRC(1-760) [plasma membrane] (R-HSA-917983)	0.935	11
UniProt:A5K736 A5K736			0.733	9
UniProt:Q9K0U9 TBPA			0.632	4
UniProt:Q09057 TBPB1			0.618	3
UniProt:P01350 GAST	1	GAST(76-92) [extracellular region] (R-HSA-870266)	0.618	5
UniProt:Q9K0V0 TBPB			0.558	2
UniProt:Q9BXS9-3 SLC26A6			0.556	3
UniProt:Q96KR6 F210B			0.556	3
UniProt:Q7Z5P4 HSD17B13	1	HSD17B13 [cytosol] (R-HSA-8862029)	0.556	3
UniProt:O15173 PGRMC2	2	PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.556	3
UniProt:O43315 AQP9	1	AQP9 [plasma membrane] (R-HSA-431761)	0.556	3
UniProt:A8MZ59 LEUTX			0.556	3
UniProt:O15529 GPR42			0.556	3
UniProt:Q8NBJ4 GOLM1	2	GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956710) p-GOLM1 [endoplasmic reticulum lumen] (R-HSA-8956938)	0.556	3
UniProt:Q9Y282 ERGI3			0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:Q8TED1 GPX8	1	GPX8 [endoplasmic reticulum lumen] (R-HSA-3341303)	0.556	3
UniProt:P08034 GJB1	2	GJB1 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190636) GJB1 [endoplasmic reticulum membrane] (R-HSA-190656)	0.556	3
UniProt:Q99523 SORT1	2	SORT1 [Golgi membrane] (R-HSA-434332) SORT1 [cytoplasmic vesicle membrane] (R-HSA-434221)	0.556	3
UniProt:Q4KMG9 TM52B			0.556	3
UniProt:Q96TC7 RMD3			0.556	3
UniProt:Q7Z7G2 CPLX4			0.556	3
UniProt:Q9GZR5 ELOVL4	1	ELOVL4 [endoplasmic reticulum membrane] (R-HSA-548705)	0.556	3
UniProt:Q8N9I0 SYT2	3	SYT2 [plasma membrane] (R-HSA-168795) SYT2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869116) SYT2 [synaptic vesicle membrane] (R-HSA-194786)	0.556	3
UniProt:O43278-2 SPINT1			0.556	3
UniProt:O00501 CLDN5	2	CLDN5 [plasma membrane] (R-HSA-419991) CLDN5 [cell junction] (R-HSA-421264)	0.556	3
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.527	6
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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