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PPP1CC [cytosol]
Stable Identifier
R-HSA-163443
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PP1CC, Serine/threonine protein phosphatase PP1-gamma catalytic subunit , PP-1G
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Mad1 binds kinetochore (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Mad1:kinetochore complex [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Separation of Sister Chromatids (Homo sapiens)
ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Separation of sister chromatids (Homo sapiens)
Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Mitotic Prometaphase (Homo sapiens)
EML4 and NUDC in mitotic spindle formation (Homo sapiens)
EML4 recruits NUDC to mitotic spindle (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Resolution of Sister Chromatid Cohesion (Homo sapiens)
CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Kinetochore assembly (Homo sapiens)
Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Circadian Clock (Homo sapiens)
CSNK1E,CSNK1D phosphorylate CRY and PER proteins (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by MRAS-complex mutants (Homo sapiens)
Mutant MRAS:SHOC2:PPP1CC complexes dephosphorylate inactive RAFs (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
mutant MRAS:SHOC2:PP1 complexes [plasma membrane] (Homo sapiens)
S-GCC MRAS mutants:GTP:SHOC2:PP1 [plasma membrane] (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
S-GCC MRAS:GTP:SHOC2 S2G:PP1 [plasma membrane] (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
SHOC2 M173I disrupts the SHOC2:MRAS:PP1 complex (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
SHOC2 M173I:MRAS:PP1 [plasma membrane] (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Triglyceride metabolism (Homo sapiens)
Triglyceride catabolism (Homo sapiens)
phosphorylated perilipin + H2O -> perilipin + orthophosphate (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAF activation (Homo sapiens)
MRAS:SHOC2:PPP1CC dephosphorylates inactive RAFs (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
S-GCC MRAS:GTP:SHOC2:PP1 [plasma membrane] (Homo sapiens)
PPP1CB, PPP1CB [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Microtubule-bound kinetochore [cytosol] (Homo sapiens)
Kinetochore [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
PP1 dephosphorylates TGFBR1 (Homo sapiens)
GADD34:PP1 [cytosol] (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] (Homo sapiens)
GADD34:PP1 [cytosol] (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR (Homo sapiens)
GADD34:PP1 [cytosol] (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] (Homo sapiens)
GADD34:PP1 [cytosol] (Homo sapiens)
PP1 catalytic subunit [cytosol] (Homo sapiens)
PPP1CC [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P36873 PPP1CC
Gene Names
PPP1CC
Chain
initiator methionine:1, chain:2-323
Reference Genes
BioGPS Gene:5501 PPP1CC
COSMIC (genes):PPP1CC PPP1CC
CTD Gene:5501 PPP1CC
dbSNP Gene:5501 PPP1CC
ENSEMBL:ENSG00000186298 PPP1CC
HGNC:9283 PPP1CC
KEGG Gene (Homo sapiens):5501 PPP1CC
Monarch:5501 PPP1CC
NCBI Gene:5501 PPP1CC
OMIM:176914 PPP1CC
UCSC:P36873 PPP1CC
Reference Transcript
RefSeq:NM_002710.3 PPP1CC
RefSeq:NM_001244974.1 PPP1CC
Other Identifiers
0005890035
11731395_a_at
11731396_s_at
11755018_a_at
16770142
200726_at
3471375
3471376
3471377
3471378
3471379
3471380
3471381
3471382
3471384
3471385
3471387
3471389
3471391
3471392
3471395
3471402
3471403
3471404
37725_at
5501
7966368
A_23_P204423
A_23_P204427
A_24_P386771
GE59987
GO:0000164
GO:0000228
GO:0000775
GO:0000776
GO:0000777
GO:0000784
GO:0003674
GO:0003723
GO:0004721
GO:0004722
GO:0005515
GO:0005521
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005739
GO:0005741
GO:0005829
GO:0005886
GO:0005925
GO:0005975
GO:0005977
GO:0006091
GO:0006464
GO:0006470
GO:0006810
GO:0006913
GO:0007049
GO:0008022
GO:0008150
GO:0008157
GO:0008283
GO:0016607
GO:0016787
GO:0016791
GO:0019899
GO:0019901
GO:0019903
GO:0019904
GO:0030154
GO:0030182
GO:0030496
GO:0032154
GO:0032922
GO:0032991
GO:0042752
GO:0043153
GO:0043167
GO:0043197
GO:0043226
GO:0044877
GO:0046822
GO:0046872
GO:0047485
GO:0048511
GO:0048856
GO:0051301
GO:0060252
GO:0072357
GO:0098793
ILMN_1701855
PH_hs_0027702
TC12001968.hg
X74008_at
g4506006_3p_at
Participant Of
hasMember
PP1 catalytic subunit [cytosol]
PPP1CB, PPP1CB [cytosol]
hasComponent
GADD34:PP1CC [cytosol]
Kinetochore [cytosol]
Inferred To
PPP1CC [cytosol] (Gallus gallus)
PPP1CC [cytosol] (Sus scrofa)
ppp1cc [cytosol] (Danio rerio)
ppp1cc [cytosol] (Xenopus tropicalis)
Ppp1cc [cytosol] (Mus musculus)
Ppp1cc [cytosol] (Rattus norvegicus)
Ghost homologue of PPP1CC [cytosol] (Canis familiaris)
Cross References
RefSeq
NP_002701.1
,
NP_001231903.1
ZINC - World Drugs
PP1G_HUMAN
OpenTargets
ENSG00000186298
ZINC - Substances
PP1G_HUMAN
ZINC - Biogenic
PP1G_HUMAN
ZINC target
P36873
PRO
P36873
PDB
1IT6
,
4UT2
,
1U32
,
2BDX
,
1JK7
,
5INB
,
2BCD
,
4UT3
,
5J28
Target Pathogen
57c09033be737e1cc0a96a78
IntEnz
3.1.3.16
HPA
ENSG00000186298-PPP1CC
GeneCards
P36873
Ensembl
ENSG00000186298
,
ENST00000340766
,
ENSP00000341779
,
ENSP00000335084
,
ENST00000335007
ZINC - Predictions - Purchasable
PP1G_HUMAN
HMDB Protein
HMDBP01893
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.814
7
UniProt:Q9UQK1 PPP1R3C
2
PPP1R3C [cytosol]
(R-HSA-3777102)
K48polyUb-PPP1R3C [cytosol]
(R-HSA-3781005)
0.666
4
UniProt:Q8WUF5 PPP1R13L
1
PPP1R13L [nucleoplasm]
(R-HSA-6799738)
0.597
3
UniProt:Q9Y230 RUVBL2
1
RUVBL2 [nucleoplasm]
(R-HSA-418321)
0.597
3
UniProt:Q96RT1 ERBIN
1
ERBIN [plasma membrane]
(R-HSA-1358718)
0.597
3
UniProt:P19388 POLR2E
2
POLR2E [cytosol]
(R-HSA-1964438)
POLR2E [nucleoplasm]
(R-HSA-83713)
0.597
3
UniProt:Q5UIP0 RIF1
1
RIF1 [nucleoplasm]
(R-HSA-480742)
0.597
3
UniProt:P03372 ESR1
8
SUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.564
3
UniProt:O95400 CD2BP2
1
CD2BP2 [nucleoplasm]
(R-HSA-72054)
0.556
3
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.527
3
UniProt:P38398 BRCA1
27
SUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
SUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
BRCA1 C64R [nucleoplasm]
(R-HSA-9700907)
BRCA1 C61G [nucleoplasm]
(R-HSA-9700890)
BRCA1 C39Y [nucleoplasm]
(R-HSA-9700938)
BRCA1 H41R [nucleoplasm]
(R-HSA-9700921)
BRCA1 C24R [nucleoplasm]
(R-HSA-9663198)
BRCA1 H41A [nucleoplasm]
(R-HSA-9700927)
BRCA1 M18T [nucleoplasm]
(R-HSA-9700911)
BRCA1 C47G [nucleoplasm]
(R-HSA-9700941)
BRCA1 C64G [nucleoplasm]
(R-HSA-9700899)
BRCA1 C44F [nucleoplasm]
(R-HSA-9700944)
BRCA1 T37R [nucleoplasm]
(R-HSA-9700934)
BRCA1 C27A [nucleoplasm]
(R-HSA-9700916)
BRCA1 H41Q [nucleoplasm]
(R-HSA-9700923)
BRCA1 Q12Tfs*5 [nucleoplasm]
(R-HSA-9700953)
BRCA1 E23Afs*18 [nucleoplasm]
(R-HSA-9700959)
BRCA1 C61Y [nucleoplasm]
(R-HSA-9700894)
BRCA1 C24F [nucleoplasm]
(R-HSA-9663206)
BRCA1 E23Rfs*18 [nucleoplasm]
(R-HSA-9700960)
BRCA1 E23Vfs*17 [nucleoplasm]
(R-HSA-9700967)
p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-5683800)
K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-9707298)
BRCA1 [nucleoplasm]
(R-HSA-50949)
K6PolyUb-BRCA1 [nucleoplasm]
(R-HSA-9701022)
K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-9707290)
p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-75234)
0.524
2
UniProt:O08785 Clock
2
p-S-Clock [nucleoplasm]
(R-MMU-508670)
Clock [cytosol]
(R-MMU-508720)
0.508
2
UniProt:O15294 OGT
2
OGT [cytosol]
(R-HSA-9687814)
OGT [nucleoplasm]
(R-HSA-3321845)
0.499
11
UniProt:Q14974 KPNB1
5
KPNB1 [nucleoplasm]
(R-HSA-180714)
KPNB1 [cytosol]
(R-HSA-180733)
KPNB1 [specific granule lumen]
(R-HSA-6799646)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
0.462
2
UniProt:P62280 RPS11
2
RPS11 [cytosol]
(R-HSA-72327)
RPS11 [nucleoplasm]
(R-HSA-6791212)
0.462
2
UniProt:Q9UBK9 UXT
1
UXT [nucleoplasm]
(R-HSA-9007484)
0.462
2
UniProt:P52292 KPNA2
2
KPNA2 [nucleoplasm]
(R-HSA-206045)
KPNA2 [cytosol]
(R-HSA-205976)
0.462
2
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