Reactome | PPP1CC [cytosol]

PPP1CC [cytosol]

Stable Identifier

R-HSA-163443

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PP1CC, Serine/threonine protein phosphatase PP1-gamma catalytic subunit , PP-1G

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Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Amplification of signal from the kinetochores (Homo sapiens)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
        
        MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        Mad1 binds kinetochore (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        Release of activated MAD2 from kinetochores (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        Separation of sister chromatids (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - EML4 and NUDC in mitotic spindle formation (Homo sapiens)
        
        EML4 recruits NUDC to mitotic spindle (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
      - Kinetochore capture of astral microtubules (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        Kinetochore assembly (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PPP1CC [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P36873 PPP1CC

Gene Names

PPP1CC

Chain

initiator methionine:1, chain:2-323

Reference Genes

BioGPS Gene:5501 PPP1CC

COSMIC (genes):PPP1CC PPP1CC

CTD Gene:5501 PPP1CC

dbSNP Gene:5501 PPP1CC

ENSEMBL:ENSG00000186298 PPP1CC

HGNC:9283 PPP1CC

KEGG Gene (Homo sapiens):5501 PPP1CC

Monarch:5501 PPP1CC

NCBI Gene:5501 PPP1CC

OMIM:176914 PPP1CC

UCSC:P36873 PPP1CC

Reference Transcript

Other Identifiers

0005890035

11731395_a_at

11731396_s_at

11755018_a_at

16770142

200726_at

3471375

3471376

3471377

3471378

3471379

3471380

3471381

3471382

3471384

3471385

3471387

3471389

3471391

3471392

3471395

3471402

3471403

3471404

37725_at

5501

7966368

A_23_P204423

A_23_P204427

A_24_P386771

GE59987

GO:0000164

GO:0000165

GO:0000278

GO:0000775

GO:0000776

GO:0000777

GO:0000781

GO:0003674

GO:0003723

GO:0004721

GO:0004722

GO:0005515

GO:0005521

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005737

GO:0005739

GO:0005741

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0005975

GO:0005977

GO:0006091

GO:0006464

GO:0006470

GO:0006810

GO:0006913

GO:0007010

GO:0007049

GO:0007052

GO:0007165

GO:0008022

GO:0008150

GO:0008157

GO:0008283

GO:0016607

GO:0016787

GO:0016791

GO:0019899

GO:0019901

GO:0019903

GO:0019904

GO:0030154

GO:0030182

GO:0030496

GO:0032154

GO:0032922

GO:0032991

GO:0042752

GO:0043153

GO:0043167

GO:0043197

GO:0043226

GO:0044877

GO:0046822

GO:0046872

GO:0047485

GO:0048511

GO:0048856

GO:0051301

GO:0060252

GO:0072357

GO:0098793

GO:0098794

GO:0098978

GO:0106306

GO:0106307

HMNXSV003005464

HMNXSV003042582

ILMN_1701855

PH_hs_0027702

TC12001968.hg

X74008_at

g4506006_3p_at

Participates

as a member of

as a component of

Inferred To

PPP1CC [cytosol] (Gallus gallus)

PPP1CC [cytosol] (Sus scrofa)

PPP1CC [cytosol] (Xenopus tropicalis)

ppp1cc [cytosol] (Danio rerio)

Ppp1cc [cytosol] (Mus musculus)

Ppp1cc [cytosol] (Rattus norvegicus)

Ghost homologue of PPP1CC [cytosol] (Canis familiaris)

pppB [cytosol] (Dictyostelium discoideum)

gsp-2 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001231903.1, NP_002701.1

ZINC - World Drugs

PP1G_HUMAN

OpenTargets

ENSG00000186298

ZINC - Substances

PP1G_HUMAN

ZINC target

P36873

ZINC - Biogenic

PP1G_HUMAN

PRO

P36873

PDB

2BDX, 1JK7, 1U32, 5J28, 4UT3, 2BCD, 1IT6, 4UT2, 5INB

IntEnz

3.1.3.16

HPA

ENSG00000186298-PPP1CC

GeneCards

P36873

Ensembl

ENSG00000186298, ENSP00000341779, ENSP00000335084, ENST00000340766, ENST00000335007

Pharos - Targets

P36873

ZINC - Predictions - Purchasable

PP1G_HUMAN

HMDB Protein

HMDBP01893

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.807	7
UniProt:Q9UQK1 PPP1R3C	2	PPP1R3C [cytosol] (R-HSA-3777102) K48polyUb-PPP1R3C [cytosol] (R-HSA-3781005)	0.666	4
UniProt:Q8WUF5 PPP1R13L	1	PPP1R13L [nucleoplasm] (R-HSA-6799738)	0.597	3
UniProt:Q96RT1 ERBIN	1	ERBIN [plasma membrane] (R-HSA-1358718)	0.569	3
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.569	3
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.569	3
UniProt:Q5UIP0 RIF1	1	RIF1 [nucleoplasm] (R-HSA-480742)	0.569	3
UniProt:P03372 ESR1	8	Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [cytosol] (R-HSA-9020968) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) PalmS-ESR1 [cytosol] (R-HSA-9020974) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302)	0.564	3
UniProt:O95400 CD2BP2	1	CD2BP2 [nucleoplasm] (R-HSA-72054)	0.556	3
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.527	3
UniProt:P38398 BRCA1	20	BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 S1009 [nucleoplasm] (R-HSA-9702755) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 S864 [nucleoplasm] (R-HSA-9702752) BRCA1 W372* [nucleoplasm] (R-HSA-9702768) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 S451* [nucleoplasm] (R-HSA-9702754) BRCA1 P724Lfs*12 [nucleoplasm] (R-HSA-9703778)	0.524	2
UniProt:O08785 Clock	2	Clock [cytosol] (R-MMU-508720) p-S-Clock [nucleoplasm] (R-MMU-508670)	0.508	2
UniProt:O15294 OGT	2	OGT [cytosol] (R-HSA-9687814) OGT [nucleoplasm] (R-HSA-3321845)	0.499	11

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