Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
GNL3 [nucleoplasm]
Stable Identifier
R-HSA-8869324
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Guanine nucleotide-binding protein-like 3, GNL3_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA (Homo sapiens)
GNL3:EBNA1BP2:DDX21:PES1 [nucleoplasm] (Homo sapiens)
GNL3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BVP2 GNL3
Gene Names
GNL3, E2IG3, NS
Chain
chain:1-549
Reference Genes
BioGPS Gene:26354 GNL3
COSMIC (genes):GNL3 GNL3
CTD Gene:26354 GNL3
dbSNP Gene:26354 GNL3
ENSEMBL:ENSG00000163938 GNL3
HGNC:29931 GNL3
Monarch:26354 GNL3
NCBI Gene:26354 GNL3
OMIM:608011 GNL3
UCSC:Q9BVP2 GNL3
Reference Transcript
RefSeq:NM_014366.4 GNL3
RefSeq:NM_206825.1 GNL3
RefSeq:NM_206826.1 GNL3
Other Identifiers
11717310_a_at
11749333_a_at
16941661
16941687
17119348
217850_PM_at
217850_at
2624075
2624076
2624077
2624078
2624079
2624081
2624082
2624083
2624084
2624085
2624086
2624087
2624088
2624089
2624091
2624092
2624093
2624095
2624096
2624097
2624098
2624099
2624100
2624101
2624102
2624103
2624104
2624105
2624106
2624107
2624108
2624109
26354
2794954
45778_at
71669_at
8080419
85559_at
A_14_P112971
A_14_P119974
A_14_P124901
A_21_P0000375
A_21_P0000462
A_23_P41025
A_32_P8120
GE63028
GE81919
GE88847
GO:0003723
GO:0005515
GO:0005525
GO:0005615
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0006355
GO:0016020
GO:0016604
GO:0017145
GO:0019827
GO:0030496
GO:0032206
GO:0033235
GO:0042127
GO:0043226
GO:0048027
GO:1902895
GO:1904816
HMNXSV003019673
HMNXSV003054322
HMNXSV003055028
ILMN_1790659
ILMN_1806106
ILMN_2324056
PH_hs_0029728
RNA147247|p0351_imsncRNA769
RNA33614|snoRNA_scaRNA_210_84
RNA33678|snoRNA_scaRNA_274_76
TC03000339.hg
TC03000340.hg
g7657047_3p_at
Participates
as a component of
GNL3:EBNA1BP2:DDX21:PES1 [nucleoplasm] (Homo sapiens)
Inferred To
GNL3 [nucleoplasm]
(Bos taurus)
GNL3 [nucleoplasm]
(Caenorhabditis elegans)
GNL3 [nucleoplasm]
(Canis familiaris)
GNL3 [nucleoplasm]
(Dictyostelium discoideum)
GNL3 [nucleoplasm]
(Drosophila melanogaster)
GNL3 [nucleoplasm]
(Mus musculus)
GNL3 [nucleoplasm]
(Rattus norvegicus)
GNL3 [nucleoplasm]
(Saccharomyces cerevisiae)
GNL3 [nucleoplasm]
(Schizosaccharomyces pombe)
GNL3 [nucleoplasm]
(Sus scrofa)
GNL3 [nucleoplasm]
(Xenopus tropicalis)
Cross References
OpenTargets
ENSG00000163938
ENSEMBL
ENSP00000378278
,
ENST00000418458
,
ENSP00000395772
,
ENST00000394799
HPA
ENSG00000163938-GNL3
PRO
Q9BVP2
Pharos - Targets
Q9BVP2
GlyGen
Q9BVP2
PDB
8IPD
,
8FL0
,
8IPY
,
8IR1
,
8IR3
,
8FKV
,
8FKP
,
8IPX
,
8INK
,
8FL2
,
8FL4
,
8FKY
,
8FKT
,
8FKR
,
8FKZ
,
8FL3
,
8FKX
,
8FKU
,
8FKW
HMDB Protein
HMDBP08432
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UKV8 AGO2
2
AGO2 [cytosol]
(R-HSA-209723)
AGO2 [nucleoplasm]
(R-HSA-5578701)
0.641
3
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.597
4
UniProt:O14746 TERT
1
TERT [nucleoplasm]
(R-HSA-163076)
0.537
3
UniProt:P40763 STAT3
12
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
0.508
2
UniProt:O00410 IPO5
1
IPO5 [nucleoplasm]
(R-HSA-192675)
0.483
3
UniProt:Q12906 ILF3
3
ILF3 [nucleoplasm]
(R-HSA-9760401)
ILF3 [cytosol]
(R-HSA-450564)
p-T188,T315-ILF3 [cytosol]
(R-HSA-9836381)
0.483
2
UniProt:Q13616 CUL1
3
CUL1 [cytosol]
(R-HSA-174230)
CUL1 [nucleoplasm]
(R-HSA-187551)
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
0.483
2
UniProt:Q9Y5B9 SUPT16H
1
SUPT16H [nucleoplasm]
(R-HSA-112415)
0.483
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text