Reactome | 5OHK15,276-U2AF2 [nucleoplasm]

5OHK15,276-U2AF2 [nucleoplasm]

Stable Identifier

R-HSA-9630011

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

5OHK15,276-U2AF 65 kDa subunit, 5OHK15,276-Splicing factor U2AF 65 kDa subunit, 5OHK15,276-U2 auxiliary factor 65 kDa subunit, 5OHK15,276-U2 snRNP auxiliary factor large subunit, 5OHK15,276-hU2AF(65)

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P26368 U2AF2

Gene Names

U2AF2, U2AF65

Chain

initiator methionine:, chain:2-475

Reference Genes

BioGPS Gene:11338 U2AF2

COSMIC (genes):U2AF2 U2AF2

CTD Gene:11338 U2AF2

dbSNP Gene:11338 U2AF2

ENSEMBL:ENSG00000063244 U2AF2

ENSEMBL_homo_sapiens_GENE:ENSG00000063244.14 U2AF2

HGNC:23156 U2AF2

KEGG Gene (Homo sapiens):11338 U2AF2

Monarch:11338 U2AF2

NCBI Gene:11338 U2AF2

OMIM:191318 U2AF2

UCSC:P26368 U2AF2

Reference Transcript

Other Identifiers

11338

11717939_a_at

11717940_at

11717941_at

11758431_s_at

16865737

218381_PM_s_at

218381_s_at

218382_PM_s_at

218382_s_at

229508_PM_at

229508_at

2722225

32556_at

3842346

3842347

3842348

3842349

3842350

3842351

3842353

3842354

3842356

3842357

3842360

3842361

3842364

3842366

3842368

3842369

3842370

3842371

3842372

3842373

3842374

3842380

54740_at

77029_at

8031536

A_23_P431418

A_33_P3302796

GE59903

GO:0000243

GO:0000398

GO:0000974

GO:0003676

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0006397

GO:0008187

GO:0008380

GO:0016071

GO:0016607

GO:0019899

GO:0030628

GO:0031397

GO:0033120

GO:0036211

GO:0043226

GO:0048025

GO:0070742

GO:0071004

GO:0089701

GO:0098772

GO:0140678

HMNXSV003002942

Hs.143493.0.A1_3p_at

Hs.7655.0.S2_3p_a_at

ILMN_1768930

ILMN_2385173

PH_hs_0023576

TC19000906.hg

TC19002243.hg

TC19002244.hg

X64044_at

g6005925_3p_a_at

Participates

as an output of

JMJD6 dimer hydroxylates lysine residues of U2AF2 (Homo sapiens)

Other forms of this molecule

U2AF2 [nucleoplasm]

Inferred To

U2af50 [nucleoplasm] (Drosophila melanogaster)

U2AF2 [nucleoplasm] (Bos taurus)

U2AF2 [nucleoplasm] (Canis familiaris)

U2AF2 [nucleoplasm] (Sus scrofa)

5OHK15,276-U2AF2 [nucleoplasm] (Gallus gallus)

5OHK15,276-U2AF2 [nucleoplasm] (Plasmodium falciparum)

u2af2 [nucleoplasm] (Dictyostelium discoideum)

u2af2 [nucleoplasm] (Xenopus tropicalis)

uaf-1 [nucleoplasm] (Caenorhabditis elegans)

MUD2 [nucleoplasm] (Saccharomyces cerevisiae)

prp2 [nucleoplasm] (Schizosaccharomyces pombe)

U2af2 [nucleoplasm] (Mus musculus)

U2af2 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

5-hydroxy-L-lysine at 15

Coordinate

PsiMod Name

(2S,5R)-5-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to 5-hydroxy-L-lysine.

Name

5-hydroxy-L-lysine at 276

Coordinate

276

PsiMod Name

(2S,5R)-5-hydroxylysine

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to 5-hydroxy-L-lysine.

Cross References

RefSeq

NP_009210.1, NP_001012496.1

OpenTargets

ENSG00000063244

HPA

ENSG00000063244-U2AF2

GeneCards

P26368

Ensembl

ENST00000450554, ENSP00000388475, ENSP00000307863, ENSG00000063244, ENST00000308924

PRO

P26368

Pharos - Targets

P26368

PDB

4TU9, 3VAG, 2G4B, 6XLV, 3VAH, 5EV3, 5EV2, 3VAI, 4FXW, 7S3A, 3VAJ, 6XLX, 1OPI, 6TR0, 5EV4, 6XLW, 2YH0, 7SN6, 2M0G, 3VAK, 8P25, 7S3C, 5W0H, 3VAL, 2YH1, 7S3B, 5W0G, 2U2F, 4TU7, 3VAM, 3VAF, 4TU8, 1U2F, 1JMT, 1O0P, 2HZC, 5EV1

Interactors (45)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01081 U2AF1	1	U2AF1 [nucleoplasm] (R-HSA-71985)	0.948	14
UniProt:Q15637 SF1	1	SF1 [nucleoplasm] (R-HSA-8865928)	0.948	23
UniProt:Q9UHX1 PUF60	1	PUF60 [nucleoplasm] (R-HSA-8865910)	0.849	7
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.803	8
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.727	6
UniProt:Q8IWZ8 SUGP1	1	SUGP1 [nucleoplasm] (R-HSA-72043)	0.713	4
UniProt:O43395 PRPF3	1	PRPF3 [nucleoplasm] (R-HSA-6806806)	0.707	4
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.703	5
UniProt:P54253 ATX1			0.674	5
UniProt:Q9NVV9 THAP1			0.666	4
UniProt:Q99590 SCAFB			0.64	5
UniProt:Q8IX12 CCAR1	1	CCAR1 [nucleoplasm] (R-HSA-72048)	0.64	3
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.64	4
UniProt:P98175 RBM10	1	RBM10 [nucleoplasm] (R-HSA-9770262)	0.632	3
UniProt:P52756 RBM5	1	RBM5 [nucleoplasm] (R-HSA-72049)	0.629	3
UniProt:Q8IWX8 CHERP	1	CHERP [nucleoplasm] (R-HSA-8865901)	0.618	3
UniProt:Q8N684 CPSF7	2	CPSF7 [cytosol] (R-HSA-9715140) CPSF7 [nucleoplasm] (R-HSA-72012)	0.618	3
UniProt:Q9UKV3 ACIN1	4	ACIN1 [cytosol] (R-HSA-212519) ACIN1(1094-1341) [cytosol] (R-HSA-212516) ACIN1(1-1093) [cytosol] (R-HSA-212520) ACIN1 [nucleoplasm] (R-HSA-9770238)	0.615	5
UniProt:Q9NWB6 ARGL1			0.583	4
UniProt:Q15287 RNPS1	2	RNPS1 [nucleoplasm] (R-HSA-156778) RNPS1 [cytosol] (R-HSA-159256)	0.564	4
UniProt:Q9UI36-2 DACH1			0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q96SB4 SRPK1	2	SRPK1 [nucleoplasm] (R-HSA-9821984) SRPK1 [cytosol] (R-HSA-9729349)	0.527	4
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	3
UniProt:P62995 TRA2B	2	TRA2B [cytosol] (R-HSA-9715137) TRA2B [nucleoplasm] (R-HSA-8850859)	0.527	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.527	2
UniProt:Q7Z7F0 KHDC4			0.519	2
UniProt:P61978 HNRNPK	2	polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.519	2
UniProt:Q9BWF3 RBM4	1	RBM4 [cytosol] (R-HSA-8878898)	0.519	2
UniProt:Q96PU8 QKI	2	QKI(1-504)-RAF1(278-648) fusion [cytosol] (R-HSA-6802466) QKI(1-504)-p-RAF1(278- 648) fusion [cytosol] (R-HSA-6802546)	0.519	2
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.519	2
UniProt:Q86VM9 ZCH18			0.483	3
UniProt:Q9NW64 RBM22	1	RBM22 [nucleoplasm] (R-HSA-5215975)	0.483	2
UniProt:Q9NYF8 BCLF1			0.483	3
UniProt:Q9UKJ3 GPTC8			0.483	2
UniProt:P46013 KI67			0.483	2
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.483	3
UniProt:Q6P2Q9 PRPF8	1	PRPF8 [nucleoplasm] (R-HSA-83810)	0.483	2
UniProt:O15042 U2SURP	1	U2SURP [nucleoplasm] (R-HSA-8865950)	0.483	4
UniProt:Q86XP3 DDX42	1	DDX42 [nucleoplasm] (R-HSA-8867894)	0.483	2
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.483	2
UniProt:O43290 SART1	1	SART1 [nucleoplasm] (R-HSA-4615999)	0.483	2
UniProt:P82979 SARNP	1	SARNP [nucleoplasm] (R-HSA-8849146)	0.471	3
UniProt:P15941 MUC1	19	MUC1(24-1255) [plasma membrane] (R-HSA-6793976) Core 8 (MUC1) [Golgi lumen] (R-HSA-1462219) Core 2S (MUC1) [Golgi lumen] (R-HSA-6786333) Core 5 (MUC1) [Golgi lumen] (R-HSA-1462231) Core 4 (MUC1) [Golgi lumen] (R-HSA-1462154) Core 3 (MUC1) [Golgi lumen] (R-HSA-1462068) Core 7 (MUC1) [Golgi lumen] (R-HSA-1462105) extended Core 6 (MUC1) [Golgi lumen] (R-HSA-1967019) Core 6 (MUC1) [Golgi lumen] (R-HSA-1462085) MUC1(24-1255) [Golgi lumen] (R-HSA-913611) Disialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463518) Sialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463531) Sialyl-2,3 T-antigen (MUC1) [Golgi lumen] (R-HSA-1463483) T-antigen (MUC1) [Golgi lumen] (R-HSA-1462359) Sialyl Tn antigen (MUC1) [Golgi lumen] (R-HSA-1463526) GalNAc-MUC1(24-1255) [Golgi lumen] (R-HSA-913642) Core 2a (MUC1) [Golgi lumen] (R-HSA-6784286) Core 2 (MUC1) [Golgi lumen] (R-HSA-1462167) GalNAc-MUC1(24-1255) [plasma membrane] (R-HSA-8858449)	0.471	2
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.462	2

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