Reactome | UTP3 [nucleoplasm]

UTP3 [nucleoplasm]

Stable Identifier

R-HSA-6790637

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Something about silencing protein 10, SAS10_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NQZ2 UTP3

Gene Names

UTP3, CRLZ1, SAS10

Chain

chain:1-479

Reference Genes

BioGPS Gene:57050 UTP3

COSMIC (genes):UTP3 UTP3

CTD Gene:57050 UTP3

dbSNP Gene:57050 UTP3

ENSEMBL:ENSG00000132467 UTP3

HGNC:24477 UTP3

Monarch:57050 UTP3

NCBI Gene:57050 UTP3

OMIM:611614 UTP3

UCSC:Q9NQZ2 UTP3

Reference Transcript

RefSeq:NM_020368.2 UTP3

Other Identifiers

11722418_at

11722419_s_at

16967557

209486_PM_at

209486_at

2730532

2730533

2730534

2730535

2730536

2730537

2730538

2730539

2730540

33150_at

57050

8095539

A_14_P129584

A_23_P92424

GE61890

GO:0000462

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0006325

GO:0007420

GO:0032040

GO:0042274

GO:0043226

GO:0048856

HMNXSV003009249

ILMN_1745423

ILMN_2090987

PH_hs_0016082

TC04000390.hg

g13528698_3p_at

Participates

as a component of

SSU Processome [nucleoplasm] (Homo sapiens)

Inferred To

Utp3 [nucleoplasm] (Mus musculus)

Utp3 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of UTP3 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of UTP3 [nucleoplasm] (Plasmodium falciparum)

SAS10 [nucleoplasm] (Saccharomyces cerevisiae)

UTP3 [nucleoplasm] (Bos taurus)

UTP3 [nucleoplasm] (Caenorhabditis elegans)

UTP3 [nucleoplasm] (Canis familiaris)

UTP3 [nucleoplasm] (Gallus gallus)

UTP3 [nucleoplasm] (Schizosaccharomyces pombe)

UTP3 [nucleoplasm] (Sus scrofa)

Sas10 [nucleoplasm] (Drosophila melanogaster)

Cross References

ENSEMBL

ENSP00000254803, ENST00000254803

OpenTargets

ENSG00000132467

HPA

ENSG00000132467-UTP3

PRO

Q9NQZ2

Pharos - Targets

Q9NQZ2

PDB

7MQA, 7MQ8, 7MQ9

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.615	4
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.536	3
UniProt:P02787 TF	6	TF [endoplasmic reticulum lumen] (R-HSA-8956763) p-TF [endoplasmic reticulum lumen] (R-HSA-8957001) apoTF [endosome membrane] (R-HSA-917974) apoTF [extracellular region] (R-HSA-350754) TF [secretory granule lumen] (R-HSA-350704) apoTF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869140)	0.527	2
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.483	2
UniProt:P36507 MAP2K2	12	p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073) MAP2K2 Y134C [cytosol] (R-HSA-9652089) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334)	0.483	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	2

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