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NCOA3 [nucleoplasm]
Stable Identifier
R-HSA-442488
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Nuclear receptor coactivator 3, NCOA3_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Activation of HOX genes during differentiation (Homo sapiens)
Activation of anterior HOX genes in hindbrain development during early embryogenesis (Homo sapiens)
HOXA1 gene is transcribed (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXA1 chromatin [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
HOXA4 gene is transcribed (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXA4 chromatin [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
HOXB1 gene is transcribed (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
HOXB1 maintains activation of HOXB1 chromatin (Homo sapiens)
atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
HOXB4 gene is transcribed (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXB4 chromatin [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
HOXD4 gene is transcribed (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXA1 chromatin (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXA1 chromatin [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXA4 chromatin (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXA4 chromatin [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXB1 chromatin (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXB4 chromatin (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXB4 chromatin [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Retinoic acid activates HOXD4 chromatin (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Expression of Adiponectin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Expression of CEBPA (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Expression of FABP4 (aP2) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Expression of Leptin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Expression of Lipoprotein lipase (LPL) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Expression of Perilipin (PLIN) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
p-S MAPK6 phosphorylates NCOA3 (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
Estrogen-responsive CTSD expression (Homo sapiens)
CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] (Homo sapiens)
NCOAs [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Estrogen-responsive GREB1 gene transcription (Homo sapiens)
GREB1 gene:nucleosome:ESR1:ESTG:ZNF217:NCOA3:NR5A2 [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Estrogen-responsive MYC gene expression (Homo sapiens)
MYC gene:HIST1H2AC nucleosome:ESR1:ESTG:EP300:NCOA3 [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Estrogen-responsive TFF1 gene expression (Homo sapiens)
ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs [nucleoplasm] (Homo sapiens)
histone acetyltransferases [nucleoplasm] (Homo sapiens)
NCOA1,NCOA3 [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
HATs and coactivators are recruited to the CTSD gene (Homo sapiens)
CTSD gene:ESR1:ESTG:SP1:USF1:USF2:NCOA:EP300:MED1 [nucleoplasm] (Homo sapiens)
NCOAs [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
NCOAs [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
Histone acetyltransferases are recruited to the TFF1 gene (Homo sapiens)
ESR1:estrogen:TFF1gene:FOXA1:GATA3:DDX5:TBP:TFIIA:CARM1,PRMT1:HATs [nucleoplasm] (Homo sapiens)
histone acetyltransferases [nucleoplasm] (Homo sapiens)
NCOA1,NCOA3 [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
histone acetyltransferases [nucleoplasm] (Homo sapiens)
NCOA1,NCOA3 [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
NCOA3 binds ESR1:estrogen:TFGA gene (Homo sapiens)
ESR1:estrogen:ERE:NCOA3:TFGA gene [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
NCOA3 recruits EP300 to ESR1:estrogen:TFGA gene:NCOA3 (Homo sapiens)
ESR1:estrogen:ERE:NCOA3:EP300 [nucleoplasm] (Homo sapiens)
ESR1:estrogen:ERE:NCOA3:TFGA gene [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
ESR1:estrogen:ERE:NCOA3:TFGA gene [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
NR5A2, ZNF217 and NCOA3 bind GREB1 promoter (Homo sapiens)
GREB1 gene:nucleosome:ESR1:ESTG:ZNF217:NCOA3:NR5A2 [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
TGFA gene expression is stimulated by the CITED1:EP300:ESR1:estrogen (Homo sapiens)
ESR1:estrogen:ERE:NCOA3:EP300 [nucleoplasm] (Homo sapiens)
ESR1:estrogen:ERE:NCOA3:TFGA gene [nucleoplasm] (Homo sapiens)
NCOA3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y6Q9 NCOA3
Gene Names
NCOA3, AIB1, BHLHE42, RAC3, TRAM1
Chain
initiator methionine:1, chain:2-1424
Reference Genes
BioGPS Gene:8202 NCOA3
COSMIC (genes):NCOA3 NCOA3
CTD Gene:8202 NCOA3
dbSNP Gene:8202 NCOA3
ENSEMBL:ENSG00000124151 NCOA3
ENSEMBL_homo_sapiens_GENE:ENSG00000124151 NCOA3
HGNC:7670 NCOA3
KEGG Gene (Homo sapiens):8202 NCOA3
Monarch:8202 NCOA3
NCBI Gene:8202 NCOA3
OMIM:601937 NCOA3
UCSC:Q9Y6Q9 NCOA3
Reference Transcript
RefSeq:NM_001174088.1 NCOA3
RefSeq:NM_006534.3 NCOA3
RefSeq:NM_181659.2 NCOA3
Other Identifiers
0001410079
11721401_a_at
11721402_a_at
11721403_s_at
11721404_s_at
11721405_s_at
11752022_s_at
11758328_s_at
16914509
1KBH
207700_s_at
209060_x_at
209061_at
209062_x_at
211352_s_at
24210
33381_at
3887636
3887655
3887661
3887664
3887665
3887666
3887668
3887669
3887670
3887671
3887674
3887675
3887676
3887677
3887678
3887679
3887680
3887681
3887682
3887683
3887684
3887685
3887686
3887688
3887689
3887690
3887691
3887693
3887694
3887695
3887696
3887697
3887698
3887699
3887701
3887702
3887703
3887704
3887705
3887706
3887707
3887708
3887709
3887710
3887711
3L3X
3L3Z
50379_at
8063211
8202
9800
A_14_P135867
A_23_P120442
A_23_P313560
A_23_P313568
AAB92368
AAC51663
AAC51677
AAC51849
AAI19002
ABO43042
AF010227
AF012108
AF016031
AF036892
AL034418
BC119001
CAB009800
CCDS13406
CCDS13407
CCDS54472
CH471077
EAW75698
EAW75702
EF488684
ENSG00000124151
ENSP00000361065
ENSP00000361066
ENSP00000361073
ENST00000371997
ENST00000371998
ENST00000372004
EntrezGene:8202
g2318005_3p_a_at
g2565049_3p_a_at
g5729725_3p_a_at
GE56107
GO:0000228
GO:0000790
GO:0000981
GO:0000988
GO:0000993
GO:0003674
GO:0003700
GO:0003713
GO:0004402
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006355
GO:0006464
GO:0007165
GO:0008134
GO:0008150
GO:0009058
GO:0010628
GO:0016573
GO:0016740
GO:0016746
GO:0016922
GO:0019899
GO:0030154
GO:0030374
GO:0030521
GO:0032870
GO:0032991
GO:0034641
GO:0035257
GO:0035624
GO:0043226
GO:0043697
GO:0045618
GO:0045893
GO:0045944
GO:0046966
GO:0046982
GO:0046983
GO:0047485
GO:0048856
GO:0050681
GO:0051276
GO:0051301
GO:0070062
GO:0071392
GO:0097718
GO:1902459
GO:2000035
GO:2001141
HGNC:7670
HPA024210
Hs.225977.1.A2_3p_a_at
Hs.225977.1.A4_3p_at
ILMN_1708805
ILMN_2347693
IPR000014
IPR009110
IPR010011
IPR011598
IPR013767
IPR014920
IPR014935
IPR017426
IPR028818
IPR032565
IPR035965
IPR036638
IPR037077
MIM:601937
NCOA3
NCOA3-201
NCOA3-202
NCOA3-203
NM_001174087
NM_001174088
NM_006534
NM_181659
NP_001167558
NP_001167559
NP_006525
NP_858045
PF00989
PF07469
PF08815
PF08832
PF14598
PF16279
PF16665
PH_hs_0024353
SM00091
SM00353
SM01151
TC20000372.hg
uc002xtk.4
uc002xtl.4
uc010ght.3
UPI000002AEE1
UPI000002AEE3
UPI000012FE45
Participant Of
hasMember
NCOA1,NCOA3 [nucleoplasm]
NCOAs [nucleoplasm]
input
NCOA3 binds ESR1:estrogen:TFGA gene
NR5A2, ZNF217 and NCOA3 bind GREB1 promoter
p-S MAPK6 phosphorylates NCOA3
PPARG:RXRA heterodimer binds to fatty acid-like ligands
Retinoic acid activates HOXA1 chromatin
Retinoic acid activates HOXA4 chromatin
Retinoic acid activates HOXB1 chromatin
Retinoic acid activates HOXB4 chromatin
Retinoic acid activates HOXD4 chromatin
hasComponent
atRA:RARA,B:RXRA at active HOXA4 chromatin [nucleoplasm]
atRA:RARA,B:RXRA at active HOXB4 chromatin [nucleoplasm]
atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm]
atRA:RARA,G:RXRA at active HOXA1 chromatin [nucleoplasm]
atRA:RARA,G:RXRA at active HOXB1 chromatin [nucleoplasm]
ESR1:estrogen:ERE:NCOA3:TFGA gene [nucleoplasm]
GREB1 gene:nucleosome:ESR1:ESTG:ZNF217:NCOA3:NR5A2 [nucleoplasm]
MYC gene:HIST1H2AC nucleosome:ESR1:ESTG:EP300:NCOA3 [nucleoplasm]
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm]
Other forms of this molecule
p-S857 NCOA3 [nucleoplasm]
Inferred To
NCOA3 [nucleoplasm] (Bos taurus)
NCOA3 [nucleoplasm] (Canis familiaris)
NCOA3 [nucleoplasm] (Danio rerio)
NCOA3 [nucleoplasm] (Gallus gallus)
NCOA3 [nucleoplasm] (Mus musculus)
NCOA3 [nucleoplasm] (Rattus norvegicus)
NCOA3 [nucleoplasm] (Sus scrofa)
NCOA3 [nucleoplasm] (Taeniopygia guttata)
NCOA3 [nucleoplasm] (Xenopus tropicalis)
Homologues of NCOA3 [nucleoplasm] (Danio rerio)
Homologues of NCOA3 [nucleoplasm] (Mus musculus)
Homologues of NCOA3 [nucleoplasm] (Sus scrofa)
Cross References
RefSeq
NP_001167559.1
,
NP_006525.2
,
NP_858045.1
OpenTargets
ENSG00000124151
GeneCards
Q9Y6Q9
DOCK Blaster
3L3Z
,
3L3X
PRO
Q9Y6Q9
BRENDA (Homo sapiens)
2.3.1.48
Orphanet
25755
PDB
3L3X
,
1KBH
,
3L3Z
HMDB Protein
HMDBP00026
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P03372 ESR1
4
SUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.688
4
UniProt:O43791 SPOP
1
SPOP [nucleoplasm]
(R-HSA-5635035)
0.632
6
UniProt:Q86X55 CARM1
1
CARM1 [nucleoplasm]
(R-HSA-400139)
0.623
13
UniProt:P61289 PSME3
2
PSME3 [cytosol]
(R-HSA-68816)
PSME3 [nucleoplasm]
(R-HSA-174310)
0.602
5
UniProt:Q09472 EP300
5
Foxo4-S-S-EP300 [nucleoplasm]
(R-HSA-9617720)
SUMO1-K1020,1024-EP300 [nucleoplasm]
(R-HSA-3899306)
FOXO4-S-S-EP300 [nucleoplasm]
(R-HSA-9617691)
p-S,T-EP300 [nucleoplasm]
(R-HSA-8878072)
EP300 [nucleoplasm]
(R-HSA-381325)
0.589
2
UniProt:P28065 PSMB9
2
PSMB9 [cytosol]
(R-HSA-68765)
PSMB9 [nucleoplasm]
(R-HSA-174334)
0.581
3
UniProt:P10276 RARA
3
SUMO2-K166,K171,K399-RARA [nucleoplasm]
(R-HSA-4341042)
SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]
(R-HSA-5334830)
RARA [nucleoplasm]
(R-HSA-446164)
0.564
2
ChEBI:90954 MCB-613
0.558
2
UniProt:Q8VIM5-1 MYOCD
0.544
5
UniProt:Q92793 CREBBP
3
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
SUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.527
12
UniProt:Q6PL18 ATAD2
1
ATAD2 [nucleoplasm]
(R-HSA-8937250)
0.524
2
UniProt:P51157 RAB28
0.508
2
UniProt:P48281
2
VDR [nucleoplasm]
(R-MMU-375512)
SUMO2-VDR [nucleoplasm]
(R-MMU-4546376)
0.508
2
UniProt:Q92731 ESR2
2
ESR2 [cytosol]
(R-HSA-9020970)
ESR2 [nucleoplasm]
(R-HSA-446165)
0.462
2
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