Reactome | NCOA3 [nucleoplasm]

NCOA3 [nucleoplasm]

Stable Identifier

R-HSA-442488

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Nuclear receptor coactivator 3, NCOA3_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9Y6Q9 NCOA3

Gene Names

NCOA3, AIB1, BHLHE42, RAC3, TRAM1

Chain

initiator methionine:1, chain:2-1424

Reference Genes

BioGPS Gene:8202 NCOA3

COSMIC (genes):NCOA3 NCOA3

CTD Gene:8202 NCOA3

dbSNP Gene:8202 NCOA3

ENSEMBL:ENSG00000124151 NCOA3

ENSEMBL:ENSG00000124151.19 NCOA3

HGNC:7670 NCOA3

KEGG Gene (Homo sapiens):8202 NCOA3

Monarch:8202 NCOA3

NCBI Gene:8202 NCOA3

OMIM:601937 NCOA3

UCSC:Q9Y6Q9 NCOA3

Reference Transcript

Other Identifiers

11721401_a_at

11721402_a_at

11721403_s_at

11721404_s_at

11721405_s_at

11752022_s_at

11758328_s_at

16914509

207700_PM_s_at

207700_s_at

209060_PM_x_at

209060_x_at

209061_PM_at

209061_at

209062_PM_x_at

209062_x_at

211352_PM_s_at

211352_s_at

33381_at

3887636

3887655

3887661

3887664

3887665

3887666

3887668

3887669

3887670

3887671

3887674

3887675

3887676

3887677

3887678

3887679

3887680

3887681

3887682

3887683

3887684

3887685

3887686

3887688

3887689

3887690

3887691

3887693

3887694

3887695

3887696

3887697

3887698

3887699

3887701

3887702

3887703

3887704

3887705

3887706

3887707

3887708

3887709

3887710

3887711

3887716

3887717

50379_at

8063211

8202

A_14_P129385

A_14_P135867

A_23_P120442

A_23_P313560

A_23_P313568

GE56107

GO:0000785

GO:0000993

GO:0003713

GO:0003824

GO:0004402

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0016740

GO:0016746

GO:0016922

GO:0023052

GO:0030154

GO:0030374

GO:0032870

GO:0032991

GO:0035624

GO:0043226

GO:0043697

GO:0045618

GO:0045944

GO:0046966

GO:0046983

GO:0048856

GO:0060090

GO:0061629

GO:0070062

GO:0071392

GO:0097718

GO:0140096

GO:0140110

GO:1902459

GO:2000035

HMNXSV003035886

Hs.225977.1.A2_3p_a_at

Hs.225977.1.A4_3p_at

ILMN_1708805

ILMN_2347693

PH_hs_0024353

TC20000372.hg

g2318005_3p_a_at

g2565049_3p_a_at

g5729725_3p_a_at

Participates

as a member of

as a component of

as an input of

Other forms of this molecule

p-S857 NCOA3 [nucleoplasm]

Inferred To

Ncoa3 [nucleoplasm] (Mus musculus)

Ncoa3 [nucleoplasm] (Rattus norvegicus)

NCOA3 [nucleoplasm] (Bos taurus)

NCOA3 [nucleoplasm] (Canis familiaris)

NCOA3 [nucleoplasm] (Danio rerio)

NCOA3 [nucleoplasm] (Gallus gallus)

NCOA3 [nucleoplasm] (Sus scrofa)

ncoa3 [nucleoplasm] (Xenopus tropicalis)

tai [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_858045.1, NP_006525.2, NP_001167559.1

Guide to Pharmacology - Targets

2695

OpenTargets

ENSG00000124151

GeneCards

Q9Y6Q9

HPA

ENSG00000124151-NCOA3

Ensembl

ENST00000371998, ENST00000371997, ENST00000372004, ENSP00000361073, ENSG00000124151, ENSP00000361065, ENSP00000361066

PRO

Q9Y6Q9

Pharos - Targets

Q9Y6Q9

Orphanet

25755

HMDB Protein

HMDBP00026

PDB

6SQC, 3L3X, 6ES7, 1KBH, 3L3Z

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03372 ESR1	8	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.688	4
UniProt:O43791 SPOP	1	SPOP [nucleoplasm] (R-HSA-5635035)	0.632	6
UniProt:Q86X55 CARM1	1	CARM1 [nucleoplasm] (R-HSA-400139)	0.623	13
UniProt:P61289 PSME3	2	PSME3 [nucleoplasm] (R-HSA-174310) PSME3 [cytosol] (R-HSA-68816)	0.602	5
UniProt:P28065 PSMB9	2	PSMB9 [nucleoplasm] (R-HSA-174334) PSMB9 [cytosol] (R-HSA-68765)	0.581	3
UniProt:P10276 RARA	3	SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm] (R-HSA-5334830) polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.564	2
ChEBI:90954 MCB-613			0.558	2
UniProt:Q8VIM5-1 MYOCD			0.544	5
UniProt:Q09472 EP300	5	monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) EP300 [nucleoplasm] (R-HSA-381325)	0.536	2
UniProt:Q92793 CREBBP	4	monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877) FOXO4-S-S-CREBBP [nucleoplasm] (R-HSA-9617684) CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545)	0.527	12
UniProt:Q6PL18 ATAD2	1	ATAD2 [nucleoplasm] (R-HSA-8937250)	0.524	2
UniProt:P51157 RAB28			0.508	2
UniProt:P48281	2	polySUMO2-VDR [nucleoplasm] (R-MMU-4546376) VDR [nucleoplasm] (R-MMU-375512)	0.508	2
UniProt:P10275 AR	4	PolyUb-AR [nucleoplasm] (R-HSA-6782984) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174)	0.483	3
UniProt:Q92731 ESR2	5	PalmS-ESR2 [cytosol] (R-HSA-9020979) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.462	2

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