Reactome | EMC3 [endoplasmic reticulum membrane]

EMC3 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9714347

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

ER membrane protein complex subunit 3

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOA GTPase cycle (Homo sapiens)
        
        RHOA binds effectors at the ER membrane (Homo sapiens)
        
        RHOA endoplasmic reticulum effectors [endoplasmic reticulum membrane] (Homo sapiens)
        
        EMC3 [endoplasmic reticulum membrane] (Homo sapiens)
        
        RHOA:GTP:RHOA endoplasmic reticulum effectors [endoplasmic reticulum membrane] (Homo sapiens)
        
        RHOA endoplasmic reticulum effectors [endoplasmic reticulum membrane] (Homo sapiens)
        
        EMC3 [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9P0I2 EMC3

Gene Names

EMC3, TMEM111

Chain

initiator methionine:, chain:2-261

Reference Genes

BioGPS Gene:55831 EMC3

COSMIC (genes):EMC3 EMC3

CTD Gene:55831 EMC3

dbSNP Gene:55831 EMC3

ENSEMBL:ENSG00000125037 EMC3

HGNC:23999 EMC3

Monarch:55831 EMC3

NCBI Gene:55831 EMC3

OMIM:620273 EMC3

UCSC:Q9P0I2 EMC3

Reference Transcript

RefSeq:NM_018447.3 EMC3

Other Identifiers

11716729_a_at

16950632

217882_PM_at

217882_at

228775_PM_at

228775_at

2662492

2662493

2662494

2662495

2662496

2662498

2662499

2662500

2662501

2662502

2662503

2662504

2662506

2662507

2662508

2662510

2662511

2662513

2662534

45604_at

55831

65717_at

72161_at

8085263

A_23_P69218

A_23_P69226

A_32_P194095

GE82376

GO:0005515

GO:0005783

GO:0005789

GO:0016020

GO:0032977

GO:0043226

GO:0045050

GO:0071816

GO:0072546

GO:0140104

HMNXSV003013211

HMNXSV003055560

Hs.44754.0.A1_3p_at

PH_hs_0026004

TC03003327.hg

g8923856_3p_at

Participates

as a candidate of

RHOA endoplasmic reticulum effectors [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

EMC3 [endoplasmic reticulum membrane] (Bos taurus)

EMC3 [endoplasmic reticulum membrane] (Canis familiaris)

EMC3 [endoplasmic reticulum membrane] (Gallus gallus)

EMC3 [endoplasmic reticulum membrane] (Sus scrofa)

Emc3 [endoplasmic reticulum membrane] (Mus musculus)

Emc3 [endoplasmic reticulum membrane] (Rattus norvegicus)

emc3 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

ENSEMBL

ENST00000245046, ENST00000470827, ENSP00000474771, ENSP00000245046

OpenTargets

ENSG00000125037

HPA

ENSG00000125037-EMC3

PRO

Q9P0I2

Pharos - Targets

Q9P0I2

PDB

7ADP, 8S9S, 8EOI, 8J0N, 6WW7, 8J0O, 7ADO, 6Z3W

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.725	7
UniProt:Q13126 MTAP	1	MTAP [cytosol] (R-HSA-1237091)	0.556	3
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.483	3

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