Reactome | CD1B [plasma membrane]

CD1B [plasma membrane]

Stable Identifier

R-HSA-197793

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

T-cell surface glycoprotein CD1b precursor, CD1B_HUMAN

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
    - TCR binds microbial lipid-based antigen via CD1 (Homo sapiens)
      - CD1:B2M:microbial lipid [plasma membrane] (Homo sapiens)
        
        CD1B:B2M:microbial lipid [plasma membrane] (Homo sapiens)
        
        CD1B:B2M [plasma membrane] (Homo sapiens)
        
        CD1B [plasma membrane] (Homo sapiens)
      - CD1:B2M:microbial lipid:TCR [plasma membrane] (Homo sapiens)
        
        CD1:B2M:microbial lipid [plasma membrane] (Homo sapiens)
        
        CD1B:B2M:microbial lipid [plasma membrane] (Homo sapiens)
        
        CD1B:B2M [plasma membrane] (Homo sapiens)
        
        CD1B [plasma membrane] (Homo sapiens)
    - TCR binds self-lipid-based antigen via CD1 (Homo sapiens)
      - CD1:B2M:self-lipid [plasma membrane] (Homo sapiens)
        
        CD1B:B2M:self lipid [plasma membrane] (Homo sapiens)
        
        CD1B:B2M [plasma membrane] (Homo sapiens)
        
        CD1B [plasma membrane] (Homo sapiens)
      - CD1:B2M:self-lipid:TCR [plasma membrane] (Homo sapiens)
        
        CD1:B2M:self-lipid [plasma membrane] (Homo sapiens)
        
        CD1B:B2M:self lipid [plasma membrane] (Homo sapiens)
        
        CD1B:B2M [plasma membrane] (Homo sapiens)
        
        CD1B [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P29016 CD1B

Gene Names

CD1B

Chain

signal peptide:1-17, chain:18-333

Reference Genes

BioGPS Gene:910 CD1B

COSMIC (genes):CD1B CD1B

CTD Gene:910 CD1B

dbSNP Gene:910 CD1B

ENSEMBL:ENSG00000158485 CD1B

HGNC:1635 CD1B

Monarch:910 CD1B

NCBI Gene:910 CD1B

OMIM:188360 CD1B

UCSC:P29016 CD1B

Reference Transcript

Other Identifiers

11731731_a_at

11731732_x_at

11747293_a_at

16695023

206749_PM_at

206749_at

2362193

2362237

2362239

2439287

2439288

2439291

2439292

2439293

2439294

2439295

2439296

2439298

2439299

2439300

34927_at

7921346

910

GE79910

GO:0001916

GO:0002250

GO:0002376

GO:0005515

GO:0005615

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005794

GO:0005829

GO:0005886

GO:0006955

GO:0008289

GO:0009897

GO:0009986

GO:0010008

GO:0016020

GO:0030883

GO:0030884

GO:0031410

GO:0043226

GO:0043231

GO:0048006

GO:0048007

GO:0071723

HMNXSV003029496

ILMN_1726230

M28826_at

TC01003371.hg

g4502644_3p_at

Participates

as a component of

CD1B:B2M [plasma membrane] (Homo sapiens)

Inferred To

CD1.2 [plasma membrane] (Gallus gallus)

Homologues of CD1B [plasma membrane] (Gallus gallus)

CD1B5 [plasma membrane] (Bos taurus)

CD1B [plasma membrane] (Gallus gallus)

CD1B [plasma membrane] (Sus scrofa)

Cross References

OpenTargets

ENSG00000158485

ENSEMBL

ENST00000368168, ENSP00000357150

HPA

ENSG00000158485-CD1B

PRO

P29016

Pharos - Targets

P29016

GlyGen

P29016

PDB

8GLE, 5WKI, 8GLG, 8DV4, 3T8X, 8GLF, 8DV3, 8GLH, 5L2K, 6D64, 3OV6, 5L2J, 4ONO, 5WL1, 5WKE, 8GLI, 1GZQ, 6CUG, 1GZP, 5WKG, 2H26, 5C9J, 1UQS

HMDB Protein

HMDBP11448

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61769 B2M	11	B2M(21-119) [plasma membrane] (R-HSA-167743) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [early endosome membrane] (R-HSA-182298)	0.779	6
UniProt:Q7KYR7 BTN2A1	1	BTN2A1 [plasma membrane] (R-HSA-8851994)	0.527	2
UniProt:Q9NZ53 PODXL2	2	OSulf-Y97,118-PODXL2 [Golgi lumen] (R-HSA-8954273) PODXL2 [Golgi lumen] (R-HSA-8954248)	0.527	2
UniProt:Q8WVV5 BTN2A2	1	BTN2A2 [plasma membrane] (R-HSA-8851047)	0.527	2
UniProt:Q86XF0 DHFR2	1	DHFR2 [cytosol] (R-HSA-2975816)	0.527	2
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.527	3