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GABRG2 [plasma membrane]
Stable Identifier
R-HSA-975350
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Gamma-aminobutyric acid receptor subunit gamma-2, GBRG2_HUMAN
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
GABA receptor activation (Homo sapiens)
GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol (Homo sapiens)
GABR heteropentamers:GABA [plasma membrane] (Homo sapiens)
GABR heteropentamers [plasma membrane] (Homo sapiens)
2GABRA:2GABRB:GABRG [plasma membrane] (Homo sapiens)
GABRGs [plasma membrane] (Homo sapiens)
GABRG2 [plasma membrane] (Homo sapiens)
2GABRA:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
GABRGs [plasma membrane] (Homo sapiens)
GABRG2 [plasma membrane] (Homo sapiens)
NPTN binds GABA A receptors (Homo sapiens)
GABR heteropentamers:GABA [plasma membrane] (Homo sapiens)
GABR heteropentamers [plasma membrane] (Homo sapiens)
2GABRA:2GABRB:GABRG [plasma membrane] (Homo sapiens)
GABRGs [plasma membrane] (Homo sapiens)
GABRG2 [plasma membrane] (Homo sapiens)
2GABRA:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
GABRGs [plasma membrane] (Homo sapiens)
GABRG2 [plasma membrane] (Homo sapiens)
GABR heteropentamers:GABA:NPTN [plasma membrane] (Homo sapiens)
GABR heteropentamers:GABA [plasma membrane] (Homo sapiens)
GABR heteropentamers [plasma membrane] (Homo sapiens)
2GABRA:2GABRB:GABRG [plasma membrane] (Homo sapiens)
GABRGs [plasma membrane] (Homo sapiens)
GABRG2 [plasma membrane] (Homo sapiens)
2GABRA:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
GABRGs [plasma membrane] (Homo sapiens)
GABRG2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB4 (Homo sapiens)
NRG2-activated ERBB4 binds GABA receptors through GABRA1 (Homo sapiens)
GABRA1 heteropentamers:GABA [plasma membrane] (Homo sapiens)
GABRA1 heteropentamers [plasma membrane] (Homo sapiens)
2GABRA1:2GABRB:GABRG [plasma membrane] (Homo sapiens)
GABRGs [plasma membrane] (Homo sapiens)
GABRG2 [plasma membrane] (Homo sapiens)
2GABRA1:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
GABRGs [plasma membrane] (Homo sapiens)
GABRG2 [plasma membrane] (Homo sapiens)
NRG2:p-ERBB4 homodimers:GABRA1 heteropentamers:GABA [plasma membrane] (Homo sapiens)
GABRA1 heteropentamers:GABA [plasma membrane] (Homo sapiens)
GABRA1 heteropentamers [plasma membrane] (Homo sapiens)
2GABRA1:2GABRB:GABRG [plasma membrane] (Homo sapiens)
GABRGs [plasma membrane] (Homo sapiens)
GABRG2 [plasma membrane] (Homo sapiens)
2GABRA1:GABRB:GABRG:GABRQ [plasma membrane] (Homo sapiens)
GABRGs [plasma membrane] (Homo sapiens)
GABRG2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P18507 GABRG2
Gene Names
GABRG2
Chain
signal peptide:1-39, chain:40-475
Reference Genes
BioGPS Gene:2566 GABRG2
COSMIC (genes):GABRG2 GABRG2
CTD Gene:2566 GABRG2
dbSNP Gene:2566 GABRG2
ENSEMBL:ENSG00000113327 GABRG2
ENSEMBL_homo_sapiens_GENE:ENSG00000113327.17 GABRG2
HGNC:4087 GABRG2
KEGG Gene (Homo sapiens):2566 GABRG2
Monarch:2566 GABRG2
NCBI Gene:2566 GABRG2
OMIM:137164 GABRG2
UCSC:P18507 GABRG2
Reference Transcript
RefSeq:NM_198904.2 GABRG2
RefSeq:NM_198903.2 GABRG2
RefSeq:NM_000816.3 GABRG2
Other Identifiers
11729599_a_at
11736261_a_at
11750156_a_at
1568612_PM_at
1568612_at
16991816
206849_3p_at
206849_PM_at
206849_at
2566
2838465
2838466
2838467
2838468
2838473
2838475
2838477
2838478
2838479
2838480
2838481
2838482
2838485
2838490
2838496
2838497
2838498
36762_at
8109677
84886_at
A_14_P105434
A_23_P213920
A_23_P410482
A_32_P25514
GE59724
GO:0004888
GO:0004890
GO:0005215
GO:0005216
GO:0005230
GO:0005237
GO:0005254
GO:0005515
GO:0005886
GO:0006811
GO:0006821
GO:0007214
GO:0007268
GO:0008503
GO:0009791
GO:0016020
GO:0022851
GO:0023052
GO:0030424
GO:0030425
GO:0030534
GO:0030594
GO:0030659
GO:0031410
GO:0032590
GO:0034220
GO:0034330
GO:0034707
GO:0042995
GO:0043005
GO:0043226
GO:0045202
GO:0045211
GO:0048856
GO:0051932
GO:0055085
GO:0060078
GO:0060089
GO:0071420
GO:0098794
GO:0098982
GO:1902476
GO:1902711
GO:1904315
GO:1904862
HMNXSV003010631
Hs2.355851.1.S1_3p_at
ILMN_1800270
ILMN_2413964
PH_hs_0000739
TC05000904.hg
X15376_at
g4557610_3p_at
g4557610_3p_s_at
Participates
as a member of
GABRGs [plasma membrane] (Homo sapiens)
Inferred To
gabrg2 [plasma membrane]
(Xenopus tropicalis)
Homologues of GABRG2 [plasma membrane]
(Caenorhabditis elegans)
Homologues of GABRG2 [plasma membrane]
(Drosophila melanogaster)
Gabrg2 [plasma membrane]
(Mus musculus)
Gabrg2 [plasma membrane]
(Rattus norvegicus)
Lcch-14A [plasma membrane]
(Drosophila melanogaster)
Grd [plasma membrane]
(Drosophila melanogaster)
GABRG2 [plasma membrane]
(Bos taurus)
GABRG2 [plasma membrane]
(Canis familiaris)
GABRG2 [plasma membrane]
(Gallus gallus)
GABRG2 [plasma membrane]
(Sus scrofa)
lgc-36 [plasma membrane]
(Caenorhabditis elegans)
lgc-37 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_944494.1
,
NP_000807.2
,
NP_944493.2
Guide to Pharmacology - Targets
414
OpenTargets
ENSG00000113327
HPA
ENSG00000113327-GABRG2
GeneCards
P18507
Ensembl
ENSP00000491909
,
ENSP00000492125
,
ENSG00000113327
,
ENSP00000410732
,
ENST00000639213
,
ENST00000639111
,
ENST00000414552
PRO
P18507
Pharos - Targets
P18507
Orphanet
16091
HMDB Protein
HMDBP02260
PDB
6X40
,
6HUO
,
6X3U
,
8SI9
,
6D6T
,
7T0Z
,
6X3Z
,
7QNE
,
6X3T
,
7T0W
,
8DD3
,
6X3X
,
6HUK
,
8DD2
,
6X3S
,
6I53
,
7QNB
,
6X3W
,
6HUJ
,
8SID
,
6HUP
,
6X3V
,
6D6U
,
6HUG
,
8SGO
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27824 CANX
2
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
0.527
2
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