Reactome | TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane]

TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Stable Identifier

R-HSA-8863953

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

Synonyms

Antigen peptide transporter 1, TAP1_HUMAN

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External Reference Information

External Reference

UniProt:Q03518 TAP1

Gene Names

TAP1, ABCB2, PSF1, RING4, Y3

Chain

chain:1-748

Reference Genes

BioGPS Gene:6890 TAP1

COSMIC (genes):TAP1 TAP1

CTD Gene:6890 TAP1

dbSNP Gene:6890 TAP1

ENSEMBL:ENSG00000168394 TAP1

HGNC:43 TAP1

KEGG:hsa:6890 TAP1

Monarch:6890 TAP1

NCBI Gene:6890 TAP1

OMIM:170260 TAP1

UCSC:Q03518 TAP1

Reference Transcript

Other Identifiers

11730729_a_at

11757351_a_at

17017979

17027144

17029788

17032476

17034791

17037271

17039977

17042487

202307_PM_s_at

202307_s_at

2950209

2950210

2950211

2950212

2950213

2950215

2950216

2950217

2950219

2950220

2950221

2950222

2950223

2950224

2950225

2950226

2950227

2950228

2950230

2950231

2950232

2950233

2950234

2950235

2950236

2950237

40153_at

6890

8125512

8178867

8180061

A_23_P59005

GE79181

GO:0002250

GO:0002376

GO:0003824

GO:0005215

GO:0005515

GO:0005524

GO:0005783

GO:0005789

GO:0006952

GO:0015031

GO:0015433

GO:0015833

GO:0016020

GO:0016787

GO:0016887

GO:0019885

GO:0023029

GO:0030670

GO:0033116

GO:0034451

GO:0042288

GO:0042605

GO:0042803

GO:0042824

GO:0042825

GO:0043226

GO:0043531

GO:0046872

GO:0046967

GO:0046978

GO:0046979

GO:0055085

GO:0140359

GO:0140657

GO:1904680

HMNXSV003048818

ILMN_1751079

ILMN_1767006

ILMN_2284794

PH_hs_0032801

TC06001574.hg

TC6_apd_hap1000105.hg

TC6_cox_hap2000199.hg

TC6_dbb_hap3000185.hg

TC6_mann_hap4000167.hg

TC6_mcf_hap5000174.hg

TC6_qbl_hap6000187.hg

TC6_ssto_hap7000169.hg

X57522_at

g9665247_3p_a_at

Participates

as a component of

TAP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

Other forms of this molecule

TAP1 [endoplasmic reticulum membrane]

TAP1 [phagocytic vesicle membrane]

Inferred To

haf-4 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)

haf-7 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)

haf-2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)

TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)

TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)

TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)

TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)

Homologues of TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)

haf-9 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)

Ghost homologue of TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)

Ghost homologue of TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Danio rerio)

haf-8 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000584.2, NP_001278951.1

Guide to Pharmacology - Targets

769

OpenTargets

ENSG00000168394

ENSEMBL

ENSP00000415660, ENSP00000413080, ENST00000383235, ENST00000354258, ENST00000424897, ENSP00000372722, ENST00000440894, ENSP00000405356, ENSP00000402316, ENSP00000401149, ENST00000439781, ENSP00000346206, ENST00000418205, ENST00000414467

HPA

ENSG00000168394-TAP1

PRO

Q03518

Pharos - Targets

Q03518

Orphanet

TAP1

GlyGen

Q03518

HMDB Protein

HMDBP10764

PDB

8T4F, 8T46, 8T4G, 8T4E, 8T4J, 8T4H, 1JJ7, 8T4I, 5U1D

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15533 TAPBP	3	TAPBP [lumenal side of endoplasmic reticulum membrane] (R-HSA-983083) TAPBP [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863976) TAPBP [phagocytic vesicle membrane] (R-HSA-1236750)	0.803	13
UniProt:P30101 PDIA3	3	PDIA3 [phagocytic vesicle] (R-HSA-1236870) PDIA3 [recycling endosome membrane] (R-HSA-8863849) PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028)	0.623	5
UniProt:Q13769 THOC5	3	THOC5 [nucleoplasm] (R-HSA-8849111) THOC5 [cytosol] (R-HSA-9682751) p-Y-THOC5 [cytosol] (R-HSA-9682738)	0.593	4
UniProt:Q14973 SLC10A1	1	SLC10A1 [plasma membrane] (R-HSA-194116)	0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:P61769 B2M	11	B2M(21-119) [plasma membrane] (R-HSA-167743) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [early endosome membrane] (R-HSA-182298)	0.527	3
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.527	2
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.499	4
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.499	2

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