Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ADAM21 [plasma membrane]
Stable Identifier
R-HSA-1297340
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Disintegrin and metalloproteinase domain-containing protein 21, ADA21_HUMAN
Locations in the PathwayBrowser
Expand all
Reproduction (Homo sapiens)
Fertilization (Homo sapiens)
Interaction With Cumulus Cells And The Zona Pellucida (Homo sapiens)
Association of ADAM and B4GALT1 With ZP3 (Homo sapiens)
Adam Complex [plasma membrane] (Homo sapiens)
ADAM21 [plasma membrane] (Homo sapiens)
Zona pellucida:B4GALT1 [extracellular region] (Homo sapiens)
Adam Complex [plasma membrane] (Homo sapiens)
ADAM21 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UKJ8 ADAM21
Gene Names
ADAM21
Chain
signal peptide:1-31, propeptide:32-196, chain:197-722
Reference Genes
BioGPS Gene:8747 ADAM21
COSMIC (genes):ADAM21 ADAM21
CTD Gene:8747 ADAM21
dbSNP Gene:8747 ADAM21
ENSEMBL:ENSG00000139985 ADAM21
ENSEMBL_homo_sapiens_GENE:ENSG00000139985.8 ADAM21
HGNC:200 ADAM21
KEGG Gene (Homo sapiens):8747 ADAM21
Monarch:8747 ADAM21
NCBI Gene:8747 ADAM21
OMIM:603713 ADAM21
UCSC:Q9UKJ8 ADAM21
Reference Transcript
RefSeq:NM_003813.3 ADAM21
Other Identifiers
11740740_at
11752430_s_at
1552579_PM_a_at
1552579_a_at
16785932
207665_PM_at
207665_at
31959_at
3542465
3542470
3542471
3542472
3542473
3542474
3542475
3542476
3542477
3542478
3542479
3542480
3542481
3542546
3570436
3570438
7975406
7979904
8747
A_14_P137791
A_23_P367420
GE54229
GO:0003824
GO:0004222
GO:0005515
GO:0005886
GO:0006508
GO:0007338
GO:0008233
GO:0008237
GO:0008584
GO:0009897
GO:0016020
GO:0016787
GO:0022414
GO:0030424
GO:0043005
GO:0043025
GO:0046872
GO:0048856
GO:0140096
GO:1990913
HMNXSV003010860
Hs2.178748.1.S1_3p_s_at
ILMN_1812112
PH_hs_0029338
TC14000424.hg
g11497039_3p_at
Participates
as a component of
Adam Complex [plasma membrane] (Homo sapiens)
Inferred To
ADAM21 [plasma membrane]
(Bos taurus)
ADAM21 [plasma membrane]
(Canis familiaris)
ADAM21 [plasma membrane]
(Danio rerio)
ADAM21 [plasma membrane]
(Mus musculus)
ADAM21 [plasma membrane]
(Sus scrofa)
ADAM21 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_003804.2
Guide to Pharmacology - Targets
1666
OpenTargets
ENSG00000139985
GeneCards
Q9UKJ8
HPA
ENSG00000139985-ADAM21
Ensembl
ENST00000679631
,
ENSP00000506213
,
ENSG00000139985
,
ENST00000603540
,
ENSP00000474385
PRO
Q9UKJ8
Pharos - Targets
Q9UKJ8
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BTN0 LRFN3
1
SALM4 [plasma membrane]
(R-HSA-197704)
0.527
3
UniProt:P27824 CANX
2
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
0.527
3
UniProt:Q86XF0 DHFR2
1
DHFR2 [cytosol]
(R-HSA-2975816)
0.527
3
UniProt:P62736 ACTA2
1
ACTA2 [cytosol]
(R-HSA-445792)
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text