Reactome | ATP6AP1 [endoplasmic reticulum membrane]

ATP6AP1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-9714332

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

V-type proton ATPase subunit S1, VAS1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15904 ATP6AP1

Gene Names

ATP6AP1, ATP6IP1, ATP6S1, VATPS1, XAP3

Chain

signal peptide:1-41, chain:42-470, propeptide:42-231

Reference Genes

BioGPS Gene:537 ATP6AP1

COSMIC (genes):ATP6AP1 ATP6AP1

CTD Gene:537 ATP6AP1

dbSNP Gene:537 ATP6AP1

ENSEMBL:ENSG00000071553 ATP6AP1

ENSEMBL_homo_sapiens_GENE:ENSG00000071553.18 ATP6AP1

HGNC:868 ATP6AP1

KEGG Gene (Homo sapiens):537 ATP6AP1

Monarch:537 ATP6AP1

NCBI Gene:537 ATP6AP1

OMIM:300197 ATP6AP1

UCSC:Q15904 ATP6AP1

Reference Transcript

Other Identifiers

11749258_a_at

11754958_s_at

17108354

207809_PM_s_at

207809_s_at

35770_at

3996382

3996383

3996384

3996385

3996386

3996388

3996390

3996391

3996392

3996393

3996394

3996395

3996396

3996397

3996398

3996399

3996400

3996401

3996402

3996403

3996405

537

8170882

A_23_P250462

D16469_at

GE79783

GO:0000139

GO:0001671

GO:0005515

GO:0005576

GO:0005615

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0006811

GO:0006879

GO:0006886

GO:0007035

GO:0007040

GO:0007042

GO:0010008

GO:0016020

GO:0016192

GO:0016469

GO:0030154

GO:0030641

GO:0030665

GO:0030672

GO:0031267

GO:0031410

GO:0033116

GO:0033176

GO:0036035

GO:0036295

GO:0043226

GO:0045202

GO:0048388

GO:0048856

GO:0051452

GO:0055065

GO:0055085

GO:0061795

GO:0070062

GO:0072659

GO:0097401

GO:0098772

GO:0098793

GO:0099638

GO:0141109

GO:1902600

HMNXSV003029783

ILMN_1697694

TC0X000771.hg

TC0X001937.hg

g4557340_3p_s_at

Participates

as a candidate of

RHOA endoplasmic reticulum effectors [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

ATP6AP1 [endosome membrane]

Inferred To

ATP6AP1 [endoplasmic reticulum membrane] (Bos taurus)

ATP6AP1 [endoplasmic reticulum membrane] (Canis familiaris)

ATP6AP1 [endoplasmic reticulum membrane] (Sus scrofa)

atp6ap1.2 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Atp6ap1 [endoplasmic reticulum membrane] (Mus musculus)

Atp6ap1 [endoplasmic reticulum membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001174.2, XP_011529481.1

OpenTargets

ENSG00000071553

ZINC - Substances

VAS1_HUMAN

ZINC target

Q15904

ZINC - Biogenic

VAS1_HUMAN

PRO

Q15904

PDB

7U4T, 6WM4, 6WLW, 6WM2, 6WM3, 7UNF

HPA

ENSG00000071553-ATP6AP1

GeneCards

Q15904

Ensembl

ENSP00000358777, ENST00000369762, ENSG00000071553

Pharos - Targets

Q15904

ZINC - Predictions - Purchasable

VAS1_HUMAN

HMDB Protein

HMDBP09536

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTD1-PRO_0000449624 REP			0.832	12
UniProt:O75787 ATP6AP2	3	ATP6AP2 [plasma membrane] (R-HSA-2022356) ATP6AP2 [tertiary granule membrane] (R-HSA-6799717) ATP6AP2 [ficolin-1-rich granule membrane] (R-HSA-6800921)	0.725	7
UniProt:Q9Y487 ATP6V0A2	2	ATP6V0A2 [phagocytic vesicle membrane] (R-HSA-1222546) ATP6V0A2 [endosome membrane] (R-HSA-912595)	0.643	4
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.569	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:atp6v0d_human EBI-27062249			0.527	2
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.527	2
UniProt:Q93050 ATP6V0A1	5	ATP6V0A1 [ficolin-1-rich granule membrane] (R-HSA-6801296) ATP6V0A1 [plasma membrane] (R-HSA-6806520) ATP6V0A1 [secretory granule membrane] (R-HSA-6801281) ATP6V0A1 [phagocytic vesicle membrane] (R-HSA-1222308) ATP6V0A1 [endosome membrane] (R-HSA-912596)	0.527	2
UniProt:P61421 ATPV0D1	3	ATP6V0D1 [endosome membrane] (R-HSA-912592) ATP6V0D1 [phagocytic vesicle membrane] (R-HSA-1222571) ATP6V0D1 [lysosomal membrane] (R-HSA-9640177)	0.527	2
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.527	4

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