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LNPEP [cytoplasmic vesicle membrane]
Stable Identifier
R-HSA-1445121
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane
Synonyms
IRAP, LNPEP, Leucyl-cystinyl aminopeptidase, LCAP_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
14-3-3 binds p-5S,T642-AS160 (TBC1D4) (Homo sapiens)
p-5S,T642-AS160:14-3-3:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
LNPEP [cytoplasmic vesicle membrane] (Homo sapiens)
p-5S,T642-AS160:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
LNPEP [cytoplasmic vesicle membrane] (Homo sapiens)
RAB8A,10,13,14 hydrolyze GTP (Homo sapiens)
AS160:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
LNPEP [cytoplasmic vesicle membrane] (Homo sapiens)
p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) (Homo sapiens)
AS160:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
LNPEP [cytoplasmic vesicle membrane] (Homo sapiens)
p-5S,T642-AS160:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
LNPEP [cytoplasmic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UIQ6 LNPEP
Gene Names
LNPEP, OTASE
Chain
chain:1-1025, chain:155-1025
Reference Genes
BioGPS Gene:4012 LNPEP
COSMIC (genes):LNPEP LNPEP
CTD Gene:4012 LNPEP
dbSNP Gene:4012 LNPEP
ENSEMBL:ENSG00000113441 LNPEP
HGNC:6656 LNPEP
KEGG:hsa:4012 LNPEP
Monarch:4012 LNPEP
NCBI Gene:4012 LNPEP
OMIM:151300 LNPEP
UCSC:Q9UIQ6 LNPEP
Reference Transcript
RefSeq:NM_005575.2 LNPEP
RefSeq:NM_175920.3 LNPEP
Participates
as a component of
p-5S,T642-AS160:14-3-3:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
p-5S,T642-AS160:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
AS160:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
Other forms of this molecule
LNPEP [early endosome lumen]
LNPEP [cytosol]
Cross References
Guide to Pharmacology - Targets
1570
ENSEMBL
ENST00000231368
,
ENSP00000231368
,
ENSG00000113441
,
ENSP00000379117
,
ENST00000395770
OpenTargets
ENSG00000113441
ZINC - Substances
LCAP_HUMAN
ZINC - Biogenic
LCAP_HUMAN
ZINC target
Q9UIQ6
PRO
Q9UIQ6
GlyGen
Q9UIQ6
PDB
4PJ6
,
5MJ6
,
8CGW
,
8CGP
,
5C97
,
5JHQ
,
4P8Q
,
7ZYF
,
8P0I
,
4Z7I
ZINC - Metabolites
LCAP_HUMAN
IntEnz
3.4.11.3
GeneCards
LNPEP
HPA
ENSG00000113441-LNPEP
Pharos - Targets
Q9UIQ6
ZINC - Predictions - Purchasable
LCAP_HUMAN
HMDB Protein
HMDBP02475
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27824 CANX
2
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
0.643
3
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