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SPCS3 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-264916
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
Maturation of hRSV A proteins (Homo sapiens)
Nascent F signal peptide is cleaved at ER membrane (Homo sapiens)
(Signal Peptidase Complex) [endoplasmic reticulum membrane] (Homo sapiens)
SPC-A [endoplasmic reticulum membrane] (Homo sapiens)
SPCS3 [endoplasmic reticulum membrane] (Homo sapiens)
SPC-C [endoplasmic reticulum membrane] (Homo sapiens)
SPCS3 [endoplasmic reticulum membrane] (Homo sapiens)
Nascent G signal peptide is cleaved at ER membrane (Homo sapiens)
(Signal Peptidase Complex) [endoplasmic reticulum membrane] (Homo sapiens)
SPC-A [endoplasmic reticulum membrane] (Homo sapiens)
SPCS3 [endoplasmic reticulum membrane] (Homo sapiens)
SPC-C [endoplasmic reticulum membrane] (Homo sapiens)
SPCS3 [endoplasmic reticulum membrane] (Homo sapiens)
Nascent sG localizes to ER lumen, gets glycosylated (Homo sapiens)
(Signal Peptidase Complex) [endoplasmic reticulum membrane] (Homo sapiens)
SPC-A [endoplasmic reticulum membrane] (Homo sapiens)
SPCS3 [endoplasmic reticulum membrane] (Homo sapiens)
SPC-C [endoplasmic reticulum membrane] (Homo sapiens)
SPCS3 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Incretin synthesis, secretion, and inactivation (Homo sapiens)
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) (Homo sapiens)
Signal peptidase hydrolyzes preproGLP-1 to proGLP-1 (Homo sapiens)
Signal Peptidase [endoplasmic reticulum membrane] (Homo sapiens)
SPCS3 [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)
Signal peptidase hydrolyzes preproGIP to proGIP (Homo sapiens)
Signal Peptidase [endoplasmic reticulum membrane] (Homo sapiens)
SPCS3 [endoplasmic reticulum membrane] (Homo sapiens)
Synthesis, secretion, and deacylation of Ghrelin (Homo sapiens)
Cleavage of the signal peptide of Preproghrelin (Homo sapiens)
Signal Peptidase [endoplasmic reticulum membrane] (Homo sapiens)
SPCS3 [endoplasmic reticulum membrane] (Homo sapiens)
Translation (Homo sapiens)
SRP-dependent cotranslational protein targeting to membrane (Homo sapiens)
Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein (Homo sapiens)
Signal Peptidase [endoplasmic reticulum membrane] (Homo sapiens)
SPCS3 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P61009 SPCS3
Gene Names
SPCS3, SPC22, UNQ1841/PRO3567
Chain
chain:1-180
Reference Genes
BioGPS Gene:60559 SPCS3
COSMIC (genes):SPCS3 SPCS3
CTD Gene:60559 SPCS3
dbSNP Gene:60559 SPCS3
ENSEMBL:ENSG00000129128 SPCS3
HGNC:26212 SPCS3
KEGG:hsa:60559 SPCS3
Monarch:60559 SPCS3
NCBI Gene:60559 SPCS3
OMIM:618854 SPCS3
UCSC:P61009 SPCS3
Reference Transcript
RefSeq:NM_021928.3 SPCS3
Other Identifiers
11721115_at
11721116_x_at
11721117_at
16972595
218817_PM_at
218817_at
221844_PM_x_at
221844_x_at
222753_PM_s_at
222753_s_at
2752561
2752562
2752563
2752564
2752565
2752567
2752568
2752569
2752570
2752571
2752572
2752574
48819_at
52044_at
56387_at
60559
77452_at
8098414
A_14_P127062
A_23_P132936
GE79584
GE85163
GE88066
GO:0005515
GO:0005783
GO:0005787
GO:0005789
GO:0006465
GO:0006508
GO:0016020
GO:0019082
GO:0043226
GO:0045047
GO:0051604
HMNXSV003043816
Hs.13323.1.S1_3p_at
ILMN_1667707
PH_hs_0028871
PH_hs_0039245
TC04000870.hg
g11345461_3p_at
g12052843_3p_a_at
Participates
as a component of
SPC-C [endoplasmic reticulum membrane] (Homo sapiens)
SPC-A [endoplasmic reticulum membrane] (Homo sapiens)
Signal Peptidase [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
Spcs3 [endoplasmic reticulum membrane]
(Mus musculus)
Spcs3 [endoplasmic reticulum membrane]
(Rattus norvegicus)
SPCS3_CANFA [endoplasmic reticulum membrane]
(Canis familiaris)
spcs3 [endoplasmic reticulum membrane]
(Danio rerio)
SPCS3 [endoplasmic reticulum membrane]
(Bos taurus)
SPCS3 [endoplasmic reticulum membrane]
(Gallus gallus)
SPCS3 [endoplasmic reticulum membrane]
(Sus scrofa)
Cross References
RefSeq
NP_068747.1
ENSEMBL
ENST00000503362
,
ENSP00000427463
OpenTargets
ENSG00000129128
HPA
ENSG00000129128-SPCS3
PRO
P61009
Pharos - Targets
P61009
GlyGen
P61009
PDB
7P2Q
,
7P2P
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
UniProt:P27824 CANX
2
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
0.483
2
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