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IL27RA [plasma membrane]
Stable Identifier
R-HSA-448478
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Interleukin-27 receptor subunit alpha, I27RA_HUMAN, WSX-1
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-27 signaling (Homo sapiens)
IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation (Homo sapiens)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
IL27RA:p-JAK1 [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
IL27RA binds JAK1 (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
IL27RA:JAK1 [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
IL27RA dimerizes (Homo sapiens)
2xIL27RA [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
Interleukin-27 binds Interleukin-27 receptor (Homo sapiens)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Homo sapiens)
IL27RA:JAK1 [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
IL27RA:JAK1 [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
Interleukin-27 dissociates from Interleukin-27 receptor (Homo sapiens)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Homo sapiens)
IL27RA:JAK1 [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
IL27RA:JAK1 [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated (Homo sapiens)
IL27:EBI3:IL27RA:JAK1:IL6ST:JAK1,JAK2,(TYK2) [plasma membrane] (Homo sapiens)
IL27RA:JAK1 [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
IL27:EBI3:IL27RA:p-JAK1:IL6ST:p-JAK1,p-JAK2,p-TYK2 [plasma membrane] (Homo sapiens)
IL27RA:p-JAK1 [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
Interleukin-35 Signalling (Homo sapiens)
IL35 binds IL27RA:IL12RB2 receptor (Homo sapiens)
IL27RA:JAK1 [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
IL35:IL27RA:JAK1:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL27RA:JAK1 [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor are phosphorylated (Homo sapiens)
IL35:IL27RA:JAK1:IL12RB2:JAK2 [plasma membrane] (Homo sapiens)
IL27RA:JAK1 [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL27RA:p-JAK1 [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
JAK1,JAK2 bound to IL27RA:IL12RB2 receptor phosphorylate STAT1,STAT3 (Homo sapiens)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Homo sapiens)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Homo sapiens)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
STAT1,STAT3 associate with IL27RA:IL12RB2 receptor (Homo sapiens)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL27RA:p-JAK1 [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT3 [plasma membrane] (Homo sapiens)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
p-STAT1, p-STAT3 dissociate from IL27RA:IL12RB2 receptor (Homo sapiens)
IL-35:IL27RA:p-JAK1:IL12RB2:p-JAK2:p-STAT1:p-STAT3 [plasma membrane] (Homo sapiens)
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
IL35:IL27RA:p-JAK1:IL12RB2:p-JAK2 [plasma membrane] (Homo sapiens)
IL27RA:p-JAK1 [plasma membrane] (Homo sapiens)
IL27RA [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6UWB1 IL27RA
Gene Names
IL27RA, CRL1, TCCR, WSX1, UNQ296/PRO336
Chain
signal peptide:1-32, chain:33-636
Reference Genes
BioGPS Gene:9466 IL27RA
COSMIC (genes):IL27RA IL27RA
CTD Gene:9466 IL27RA
dbSNP Gene:9466 IL27RA
ENSEMBL:ENSG00000104998 IL27RA
ENSEMBL:ENSG00000288185 IL27RA
HGNC:17290 IL27RA
KEGG Gene (Homo sapiens):9466 IL27RA
Monarch:9466 IL27RA
NCBI Gene:9466 IL27RA
OMIM:605350 IL27RA
UCSC:Q6UWB1 IL27RA
Reference Transcript
RefSeq:NM_004843.3 IL27RA
Other Identifiers
0006620017
11729821_at
16858941
205926_at
222062_at
37843_i_at
37844_at
3822552
3822553
3822555
3822556
3822558
3822559
3822561
3822563
3822564
3822565
3822566
3822567
3822568
3822569
3822570
3822571
3822572
3822573
3822575
48750_at
8026272
9466
A_23_P27606
A_24_P348326
GE80277
GO:0002376
GO:0002692
GO:0002827
GO:0002829
GO:0003674
GO:0004888
GO:0004896
GO:0005143
GO:0005515
GO:0005575
GO:0005886
GO:0005887
GO:0006259
GO:0006950
GO:0006955
GO:0007155
GO:0007165
GO:0007166
GO:0008150
GO:0008283
GO:0009897
GO:0016020
GO:0016021
GO:0019221
GO:0019955
GO:0032700
GO:0032715
GO:0032720
GO:0032729
GO:0032991
GO:0034641
GO:0040011
GO:0042019
GO:0042022
GO:0042104
GO:0043235
GO:0045509
GO:0048302
GO:0048856
GO:0048870
GO:0050830
GO:0070106
GO:0070757
GO:0072536
GO:2000317
GO:2000408
HMNXSV003038831
Hs.132781.1.A1_3p_at
ILMN_1688152
PH_hs_0007956
TC19000250.hg
g4759327_3p_x_at
Participates
as a component of
IL12A:EBI3:IL12RB2:p-JAK1:IL27RA:p-JAK2 [plasma membrane] (Homo sapiens)
2xIL27RA [plasma membrane] (Homo sapiens)
IL27RA:p-JAK1 [plasma membrane] (Homo sapiens)
IL27RA:JAK1 [plasma membrane] (Homo sapiens)
as an input of
IL27RA binds JAK1 (Homo sapiens)
IL27RA dimerizes (Homo sapiens)
Other forms of this molecule
sIL27RA [cytoplasm]
sIL27RA [extracellular region]
p-Y611-IL27RA [plasma membrane]
Inferred To
Homologues of IL27RA [plasma membrane]
(Danio rerio)
IL27RA [plasma membrane]
(Bos taurus)
IL27RA [plasma membrane]
(Canis familiaris)
IL27RA [plasma membrane]
(Sus scrofa)
il12rb2l [plasma membrane]
(Danio rerio)
Il27ra [plasma membrane]
(Mus musculus)
Il27ra [plasma membrane]
(Rattus norvegicus)
il6st [plasma membrane]
(Danio rerio)
il6st [plasma membrane]
(Xenopus tropicalis)
il12rb2 [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_004834.1
Guide to Pharmacology - Targets
2318
OpenTargets
ENSG00000104998
GeneCards
Q6UWB1
HPA
ENSG00000104998-IL27RA
Ensembl
ENSG00000104998
,
ENST00000672064
,
ENSP00000500946
,
ENST00000263379
,
ENSP00000263379
,
ENSG00000288185
PRO
Q6UWB1
Pharos - Targets
Q6UWB1
Orphanet
28711
GlyGen
Q6UWB1
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96JW4 SLC41A2
1
SLC41A2 [plasma membrane]
(R-HSA-442666)
0.556
3
UniProt:Q6PL45-2 BRICD5
0.556
3
UniProt:Q96EC8 YIPF6
2
YIPF6 [Golgi membrane]
(R-HSA-434346)
YIPF6 [cytoplasmic vesicle membrane]
(R-HSA-434199)
0.556
3
UniProt:Q96Q80 DERL3
1
DERL3 [endoplasmic reticulum membrane]
(R-HSA-8866516)
0.556
3
UniProt:Q5J5C9 DEFB121
3
DEFB121(?-76) [extracellular region]
(R-HSA-1471330)
DEFB121(?-76) [Golgi lumen]
(R-HSA-975806)
DEFB121(1-76) [Golgi lumen]
(R-HSA-1470037)
0.556
3
UniProt:Q8N3T1 GALNT15
1
GALNT15 [Golgi membrane]
(R-HSA-913705)
0.556
3
UniProt:Q6N075 MFSD5
0.556
3
UniProt:P57739 CLDN2
2
CLDN2 [plasma membrane]
(R-HSA-419994)
CLDN2 [cell junction]
(R-HSA-421235)
0.556
3
UniProt:P0DTD1-PRO_0000449624 REP
0.488
2
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