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NCSTN [plasma membrane]
Stable Identifier
R-HSA-2534241
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Nicastrin, NICA_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPH-ephrin mediated repulsion of cells (Homo sapiens)
gamma-secretase cleaves EPHB2 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
NCSTN [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
NCSTN [plasma membrane] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
NCSTN [plasma membrane] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
E-cadherin degradation by PS1:NCSTN (Gamma-secretase) (Homo sapiens)
PS1:NCSTN [plasma membrane] (Homo sapiens)
NCSTN [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule membrane proteins (Homo sapiens)
Azurophil granule membrane proteins [plasma membrane] (Homo sapiens)
NCSTN [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRIF signals cell death from the nucleus (Homo sapiens)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
NCSTN [plasma membrane] (Homo sapiens)
Regulated proteolysis of p75NTR (Homo sapiens)
gamma-secretase cleaves the p75NTR transmembrane domain (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
NCSTN [plasma membrane] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
Activated NOTCH1 Transmits Signal to the Nucleus (Homo sapiens)
Cleavage of CNTN1:NOTCH1 complex releases NICD1 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
NCSTN [plasma membrane] (Homo sapiens)
Cleavage of DNER:NOTCH1 complex releases NICD1 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
NCSTN [plasma membrane] (Homo sapiens)
NEXT1 is cleaved to produce NICD1 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
NCSTN [plasma membrane] (Homo sapiens)
Signaling by NOTCH2 (Homo sapiens)
NOTCH2 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
NCSTN [plasma membrane] (Homo sapiens)
NEXT2 is cleaved to produce NICD2 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
NCSTN [plasma membrane] (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
NEXT3 is cleaved to produce NICD3 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
NCSTN [plasma membrane] (Homo sapiens)
Noncanonical activation of NOTCH3 (Homo sapiens)
Gamma-secretase cleaves YBX1:NOTCH3 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
NCSTN [plasma membrane] (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
NOTCH4 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
Gamma-secretase cleaves NOTCH4 (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
NCSTN [plasma membrane] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB4 (Homo sapiens)
Nuclear signaling by ERBB4 (Homo sapiens)
Cleavage of ERBB4m80 by gamma-scretase complex (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
NCSTN [plasma membrane] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGFBR3 (Homo sapiens)
TGFBR3 PTM regulation (Homo sapiens)
TGFBR3(784-851) degradation (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
NCSTN [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92542 NCSTN
Gene Names
NCSTN, KIAA0253, UNQ1874/PRO4317
Chain
signal peptide:1-33, chain:34-709
Reference Genes
BioGPS Gene:23385 NCSTN
COSMIC (genes):NCSTN NCSTN
CTD Gene:23385 NCSTN
dbSNP Gene:23385 NCSTN
ENSEMBL:ENSG00000162736 NCSTN
ENSEMBL_homo_sapiens_GENE:ENSG00000162736.18 NCSTN
HGNC:17091 NCSTN
KEGG Gene (Homo sapiens):23385 NCSTN
Monarch:23385 NCSTN
NCBI Gene:23385 NCSTN
OMIM:605254 NCSTN
UCSC:Q92542 NCSTN
Reference Transcript
RefSeq:NM_015331.2 NCSTN
RefSeq:NM_001290184.1 NCSTN
RefSeq:NM_001290186.1 NCSTN
Other Identifiers
11715676_s_at
11715677_x_at
11749182_a_at
16672598
208759_PM_at
208759_at
23385
2363087
2363092
2363096
2363098
2363100
2363103
2363104
2363106
2363107
2363108
2363109
2363114
2363116
2363117
2363118
2363119
2363122
2363124
2363125
34835_at
7906576
A_23_P34402
D87442_at
GE57397
GO:0000139
GO:0002262
GO:0002376
GO:0003824
GO:0004175
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005765
GO:0005768
GO:0005769
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0005925
GO:0006508
GO:0006509
GO:0007212
GO:0007215
GO:0007219
GO:0007220
GO:0007611
GO:0008021
GO:0008233
GO:0010008
GO:0010950
GO:0012501
GO:0016020
GO:0016485
GO:0016787
GO:0021549
GO:0022010
GO:0023052
GO:0030154
GO:0030534
GO:0030659
GO:0030674
GO:0031293
GO:0031410
GO:0032991
GO:0034205
GO:0035577
GO:0042098
GO:0042383
GO:0042470
GO:0042500
GO:0042734
GO:0042982
GO:0042983
GO:0042986
GO:0042987
GO:0043085
GO:0043226
GO:0048856
GO:0050435
GO:0050673
GO:0050877
GO:0051117
GO:0051402
GO:0051604
GO:0060090
GO:0070062
GO:0070765
GO:0070851
GO:0071277
GO:0097060
GO:0140096
GO:1900271
GO:1901135
GO:1990926
HMNXSV003002299
HMNXSV003055337
ILMN_1735180
PH_hs_0000488
g9992877_3p_at
Participates
as a component of
PS1:NCSTN [plasma membrane] (Homo sapiens)
gamma-secretase complex [plasma membrane] (Homo sapiens)
as a member of
Azurophil granule membrane proteins [plasma membrane] (Homo sapiens)
Other forms of this molecule
NCSTN [endosome membrane]
NCSTN [azurophil granule membrane]
Inferred To
Nct [plasma membrane]
(Drosophila melanogaster)
NCSTN [plasma membrane]
(Bos taurus)
NCSTN [plasma membrane]
(Canis familiaris)
NCSTN [plasma membrane]
(Gallus gallus)
NCSTN [plasma membrane]
(Sus scrofa)
ncstn [plasma membrane]
(Dictyostelium discoideum)
ncstn [plasma membrane]
(Xenopus tropicalis)
Ghost homologue of NCSTN [plasma membrane]
(Danio rerio)
Ncstn [plasma membrane]
(Mus musculus)
Ncstn [plasma membrane]
(Rattus norvegicus)
aph-2 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001277113.1
,
NP_001277115.1
,
NP_056146.1
OpenTargets
ENSG00000162736
GeneCards
Q92542
HPA
ENSG00000162736-NCSTN
Ensembl
ENSP00000294785
,
ENSG00000162736
,
ENST00000294785
PRO
Q92542
Pharos - Targets
Q92542
Orphanet
20181
PDB
2N7Q
,
6LR4
,
5FN4
,
5FN3
,
8IM7
,
4UIS
,
6IYC
,
7Y5X
,
8K8E
,
7C9I
,
7Y5Z
,
5A63
,
2N7R
,
8OQY
,
5FN5
,
6LQG
,
6IDF
,
7D8X
,
7Y5T
,
5FN2
,
8OQZ
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35613 BSG
2
BSG [Golgi membrane]
(R-HSA-204478)
BSG [plasma membrane]
(R-HSA-197673)
0.591
6
UniProt:P27824 CANX
2
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
0.527
2
UniProt:Q15363 TMED2
5
TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-1911531)
TMED2 [endoplasmic reticulum membrane]
(R-HSA-5689480)
TMED2 [ER to Golgi transport vesicle membrane]
(R-HSA-5689847)
TMED2 [transport vesicle]
(R-HSA-6808806)
TMED2 [Golgi membrane]
(R-HSA-6808804)
0.524
2
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