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WNT3A [extracellular region]
Stable Identifier
R-HSA-201710
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of paraxial mesoderm (Homo sapiens)
Expression of TBX6 in paraxial mesoderm (Homo sapiens)
WNT3A [extracellular region] (Homo sapiens)
Specification of the neural plate border (Homo sapiens)
Expression of MSX1 in the neural plate border (Homo sapiens)
WNT3A [extracellular region] (Homo sapiens)
Expression of PAX3 in the neural plate border (Homo sapiens)
WNT3A [extracellular region] (Homo sapiens)
Expression of PAX7 in the neural plate border (Homo sapiens)
WNT3A [extracellular region] (Homo sapiens)
Expression of TFAP2A in the neural plate border (Homo sapiens)
WNT3A [extracellular region] (Homo sapiens)
Expression of ZIC1 in the neural plate border (Homo sapiens)
WNT3A [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
Frizzled receptors bind Wnts (Homo sapiens)
Frizzled receptors:WNTs [plasma membrane] (Homo sapiens)
WNTs [extracellular region] (Homo sapiens)
WNT3A [extracellular region] (Homo sapiens)
WNTs [extracellular region] (Homo sapiens)
WNT3A [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P56704 WNT3A
Gene Names
WNT3A
Chain
signal peptide:1-18, chain:19-352
Reference Genes
BioGPS Gene:89780 WNT3A
COSMIC (genes):WNT3A WNT3A
CTD Gene:89780 WNT3A
dbSNP Gene:89780 WNT3A
ENSEMBL:ENSG00000154342 WNT3A
HGNC:15983 WNT3A
KEGG:hsa:89780 WNT3A
Monarch:89780 WNT3A
NCBI Gene:89780 WNT3A
OMIM:606359 WNT3A
UCSC:P56704 WNT3A
Reference Transcript
RefSeq:NM_033131.3 WNT3A
Other Identifiers
11734990_at
11734991_a_at
11745684_a_at
16678295
2383708
2383709
2383715
2383721
2383724
2383725
7910217
89780
A_14_P122078
A_23_P385690
A_33_P3417502
GE507271
GO:0001649
GO:0001701
GO:0001756
GO:0001819
GO:0001934
GO:0001947
GO:0002092
GO:0002376
GO:0003713
GO:0005102
GO:0005109
GO:0005125
GO:0005515
GO:0005576
GO:0005615
GO:0005788
GO:0005796
GO:0005886
GO:0006351
GO:0006355
GO:0006366
GO:0007155
GO:0007275
GO:0007368
GO:0007409
GO:0007411
GO:0007498
GO:0007507
GO:0008104
GO:0008283
GO:0008284
GO:0009952
GO:0009986
GO:0010387
GO:0010468
GO:0010628
GO:0010977
GO:0016055
GO:0019904
GO:0021527
GO:0021766
GO:0021846
GO:0021874
GO:0021904
GO:0022008
GO:0030097
GO:0030154
GO:0030168
GO:0030182
GO:0030198
GO:0030666
GO:0030879
GO:0030890
GO:0030901
GO:0031901
GO:0033138
GO:0033278
GO:0035567
GO:0035914
GO:0036342
GO:0036465
GO:0039706
GO:0042100
GO:0042472
GO:0042802
GO:0043226
GO:0045165
GO:0045202
GO:0045444
GO:0045445
GO:0045595
GO:0045599
GO:0045893
GO:0045944
GO:0048018
GO:0048103
GO:0048337
GO:0048343
GO:0048643
GO:0048697
GO:0048843
GO:0048856
GO:0050768
GO:0050770
GO:0050804
GO:0050807
GO:0055085
GO:0060070
GO:0060090
GO:0060923
GO:0061184
GO:0062009
GO:0065003
GO:0070062
GO:0070507
GO:0070527
GO:0071300
GO:0090245
GO:0090263
GO:0090676
GO:0098772
GO:0098793
GO:0098978
GO:0099054
GO:0140110
GO:1903078
GO:1904339
GO:1904692
GO:1904948
GO:1905539
GO:1905606
GO:1990851
GO:2000049
GO:2000179
GO:2000347
GO:2000727
GO:2001141
HMNXSV003010642
ILMN_1815700
PH_hs_0016549
TC01001883.hg
Participates
as a member of
WNTs [extracellular region] (Homo sapiens)
This entity regulates
Positively
Expression of ZIC1 in the neural plate border
(Homo sapiens)
Expression of PAX3 in the neural plate border
(Homo sapiens)
Expression of MSX1 in the neural plate border
(Homo sapiens)
Expression of PAX7 in the neural plate border
(Homo sapiens)
Expression of TFAP2A in the neural plate border
(Homo sapiens)
Expression of TBX6 in paraxial mesoderm
(Homo sapiens)
Other forms of this molecule
N4GlycoAsn-PalmS WNT3A [plasma membrane]
N4GlycoAsn-PalmS WNT3A [extracellular region]
N4GlycoAsn-PalmS WNT3A [Golgi lumen]
N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen]
N4GlycoAsn-WNT3A [endoplasmic reticulum lumen]
WNT3A [endoplasmic reticulum lumen]
N4GlycoAsn-PalmS WNT3A [early endosome membrane]
N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane]
N4GlycoAsn-PalmS WNT3A [extracellular exosome]
Cross References
RefSeq
NP_149122.1
OpenTargets
ENSG00000154342
ENSEMBL
ENST00000284523
,
ENSP00000284523
HPA
ENSG00000154342-WNT3A
ZINC - Substances
WNT3A_HUMAN
ZINC target
P56704
PRO
P56704
Pharos - Targets
P56704
Orphanet
WNT3A
GlyGen
P56704
ZINC - Predictions - Purchasable
WNT3A_HUMAN
PDB
7DRT
,
7URD
,
7URE
,
8TZR
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5T9L3 WLS
5
WLS [extracellular exosome]
(R-HSA-3781960)
WLS [endocytic vesicle membrane]
(R-HSA-3781954)
WLS [early endosome membrane]
(R-HSA-3247745)
WLS [Golgi membrane]
(R-HSA-3247747)
WLS [plasma membrane]
(R-HSA-3247746)
0.721
5
UniProt:O75581 LRP6
8
LRP6 [plasma membrane]
(R-HSA-206252)
p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-1458895)
p-2S,S1490,2T-LRP6 [plasma membrane]
(R-HSA-1458894)
LRP6N [extracellular region]
(R-HSA-5334021)
p-LRP6 [early endosome membrane]
(R-HSA-5368496)
LRP6 [early endosome membrane]
(R-HSA-5368481)
p-S1490-LRP6 [plasma membrane]
(R-HSA-206156)
p-T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-205884)
0.702
3
UniProt:P27824 CANX
2
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
0.527
3
UniProt:Q66LE6 PPP2R2D
1
PPP2R2D [nucleoplasm]
(R-HSA-2160962)
0.527
2
UniProt:Q16537 PPP2R5E
1
PPP2R5E [cytosol]
(R-HSA-1638770)
0.527
3
UniProt:Q9UK73 FEM1B
1
FEM1B [cytosol]
(R-HSA-201572)
0.527
2
UniProt:P56703 WNT3
9
WNT3 [extracellular region]
(R-HSA-201676)
N4GlycoAsn-PalmS WNT3 [extracellular exosome]
(R-HSA-3781966)
N4GlycoAsn-PalmS WNT3 [endocytic vesicle membrane]
(R-HSA-3781967)
WNT3 [endoplasmic reticulum lumen]
(R-HSA-3238288)
N4GlycoAsn-WNT3 [endoplasmic reticulum lumen]
(R-HSA-3238227)
N4GlycoAsn-PalmS WNT3 [endoplasmic reticulum lumen]
(R-HSA-3238342)
N4GlycoAsn-PalmS WNT3 [Golgi lumen]
(R-HSA-3247818)
N4GlycoAsn-PalmS WNT3 [extracellular region]
(R-HSA-3247786)
N4GlycoAsn-PalmS WNT3 [plasma membrane]
(R-HSA-3247830)
0.527
2
UniProt:Q15172 PPP2R5A
2
p-S28-PPP2R5A [cytosol]
(R-HSA-9836658)
PPP2R5A [cytosol]
(R-HSA-196235)
0.527
3
UniProt:Q8J025 APCD1
0.524
3
UniProt:Q9H461 FZD8
2
ub-FZD8 [plasma membrane]
(R-HSA-4641183)
FZD8 [plasma membrane]
(R-HSA-443947)
0.499
2
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