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SLC12A2 [plasma membrane]
Stable Identifier
R-HSA-426146
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Solute carrier family 12 member 2, S12A2_HUMAN
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
Cation-coupled Chloride cotransporters (Homo sapiens)
SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol (Homo sapiens)
SLC12A1,2 [plasma membrane] (Homo sapiens)
SLC12A2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P55011 SLC12A2
Gene Names
SLC12A2, NKCC1
Chain
chain:1-1212
Reference Genes
BioGPS Gene:6558 SLC12A2
COSMIC (genes):SLC12A2 SLC12A2
CTD Gene:6558 SLC12A2
dbSNP Gene:6558 SLC12A2
ENSEMBL:ENSG00000064651 SLC12A2
HGNC:10911 SLC12A2
KEGG:hsa:6558 SLC12A2
Monarch:6558 SLC12A2
NCBI Gene:6558 SLC12A2
OMIM:600840 SLC12A2
UCSC:P55011 SLC12A2
Reference Transcript
RefSeq:NM_001046.2 SLC12A2
Other Identifiers
11724133_s_at
11724134_a_at
11745260_x_at
16988801
204404_PM_at
204404_at
225835_PM_at
225835_at
2827539
2827540
2827541
2827542
2827543
2827544
2827545
2827558
2827559
2827560
2827568
2827569
2827570
2827571
2827572
2827573
2827577
2827578
2827579
2827580
2827581
2827585
2827586
2827588
2827589
2827590
2827592
2827594
2827595
2827596
2827597
2827598
2827600
2827601
2827602
2827603
2827604
2827605
2827606
2827607
2827608
37423_at
58621_at
65492_at
6558
8107769
A_14_P139508
A_23_P133606
A_32_P25437
GE59065
GE87002
GO:0002376
GO:0003013
GO:0005215
GO:0005515
GO:0005886
GO:0006811
GO:0006813
GO:0006814
GO:0006821
GO:0006883
GO:0006884
GO:0006972
GO:0007214
GO:0008511
GO:0008519
GO:0009925
GO:0010818
GO:0015079
GO:0015293
GO:0015377
GO:0016020
GO:0016323
GO:0016324
GO:0016328
GO:0019901
GO:0022857
GO:0023052
GO:0030007
GO:0030321
GO:0030644
GO:0030659
GO:0031253
GO:0035633
GO:0035725
GO:0035865
GO:0042995
GO:0043005
GO:0043025
GO:0043226
GO:0044297
GO:0044298
GO:0045795
GO:0046873
GO:0048870
GO:0051087
GO:0051879
GO:0055064
GO:0055075
GO:0055078
GO:0055085
GO:0061044
GO:0070062
GO:0070634
GO:0071805
GO:0071944
GO:0072488
GO:0098658
GO:0098659
GO:0098719
GO:0150003
GO:0150104
GO:1902476
GO:1903561
GO:1904450
GO:1904464
GO:1990573
GO:1990869
HMNXSV003051862
Hs.172129.0.A1_3p_at
ILMN_1720996
ILMN_2059452
PH_hs_0027210
TC05000612.hg
TC05002611.hg
TC05002612.hg
U30246_at
g4506974_3p_at
Participates
as a member of
SLC12A1,2 [plasma membrane] (Homo sapiens)
Inferred To
SLC12A2 [plasma membrane]
(Bos taurus)
SLC12A2 [plasma membrane]
(Canis familiaris)
SLC12A2 [plasma membrane]
(Danio rerio)
SLC12A2 [plasma membrane]
(Gallus gallus)
SLC12A2 [plasma membrane]
(Mus musculus)
SLC12A2 [plasma membrane]
(Sus scrofa)
Slc12a2 [plasma membrane]
(Rattus norvegicus)
Ncc69 [plasma membrane]
(Drosophila melanogaster)
slc12a2 [plasma membrane]
(Xenopus tropicalis)
nkcc-1 [plasma membrane]
(Caenorhabditis elegans)
Cross References
Guide to Pharmacology - Targets
969
ENSEMBL
ENSP00000340878
,
ENSP00000262461
,
ENSG00000064651
,
ENST00000262461
,
ENST00000343225
OpenTargets
ENSG00000064651
ZINC - Substances
S12A2_HUMAN
ZINC target
P55011
PRO
P55011
GlyGen
P55011
PDB
7SFL
,
7N3N
,
6PZT
,
7ZGO
,
7S1X
,
7SMP
,
7S1Z
,
7D10
,
7S1Y
,
8STE
,
7MXO
GeneCards
SLC12A2
HPA
ENSG00000064651-SLC12A2
Pharos - Targets
P55011
Orphanet
SLC12A2
HMDB Protein
HMDBP02878
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P15311 EZR
3
p-Y146,Y354-EZR [cytosol]
(R-HSA-374572)
p-T567-EZR [cytosol]
(R-HSA-374559)
EZR [cytosol]
(R-HSA-9020826)
0.589
3
UniProt:P27824 CANX
2
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
0.569
4
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