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SOAT1 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-8876490
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Sterol O-acyltransferase 1 ecNumber evidence="4"2.3.1.26/ecNumber, SOAT1_HUMAN
Locations in the PathwayBrowser
Expand all
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein clearance (Homo sapiens)
LDL clearance (Homo sapiens)
SOAT1,2 transfer acyl group to CHOL forming CHEST (Homo sapiens)
SOAT1,2 [endoplasmic reticulum membrane] (Homo sapiens)
SOAT1 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35610 SOAT1
Gene Names
SOAT1, ACACT, ACACT1, ACAT, ACAT1, SOAT, STAT
Chain
chain:1-550
Reference Genes
BioGPS Gene:6646 SOAT1
COSMIC (genes):ACAT1 SOAT1
COSMIC (genes):SOAT1 SOAT1
CTD Gene:6646 SOAT1
dbSNP Gene:6646 SOAT1
ENSEMBL:ENSG00000057252 SOAT1
HGNC:11177 SOAT1
KEGG:hsa:6646 SOAT1
Monarch:6646 SOAT1
NCBI Gene:6646 SOAT1
OMIM:102642 SOAT1
UCSC:P35610 SOAT1
Reference Transcript
RefSeq:XM_011509911.1 SOAT1
RefSeq:NM_001252511.1 SOAT1
RefSeq:NM_003101.5 SOAT1
RefSeq:NM_001252512.1 SOAT1
Other Identifiers
11724013_a_at
11724014_a_at
11745276_a_at
16674355
221561_PM_at
221561_at
228479_PM_at
228479_at
2369560
2369561
2369562
2369563
2369564
2369569
2369577
2369578
2369579
2369580
2369581
2369582
2369583
2369584
2369585
2369587
2369589
2369590
2369591
2369592
2369593
2369594
2369595
2369596
2369597
2369598
2369599
2369604
2369606
2369608
244661_PM_at
244661_at
47907_at
62428_at
6646
7907702
90190_at
90505_r_at
A_14_P132241
A_23_P63319
A_24_P216654
A_32_P103131
GE61798
GO:0000062
GO:0003824
GO:0004772
GO:0005515
GO:0005783
GO:0005789
GO:0006629
GO:0008203
GO:0008289
GO:0008374
GO:0010742
GO:0010878
GO:0015485
GO:0016020
GO:0016740
GO:0016746
GO:0030154
GO:0033344
GO:0034379
GO:0034383
GO:0034736
GO:0042632
GO:0042802
GO:0042986
GO:0043226
GO:0065003
HMNXSV003015980
Hs.148376.0.A1_3p_at
Hs.15702.0.A1_3p_at
ILMN_1699100
L21934_at
PH_hs_0026085
TC01001551.hg
g4878021_3p_at
Participates
as a member of
SOAT1,2 [endoplasmic reticulum membrane] (Homo sapiens)
Inferred To
mboa-1 [endoplasmic reticulum membrane]
(Caenorhabditis elegans)
SOAT1 [endoplasmic reticulum membrane]
(Bos taurus)
SOAT1 [endoplasmic reticulum membrane]
(Canis familiaris)
SOAT1 [endoplasmic reticulum membrane]
(Gallus gallus)
SOAT1 [endoplasmic reticulum membrane]
(Mus musculus)
SOAT1 [endoplasmic reticulum membrane]
(Rattus norvegicus)
SOAT1 [endoplasmic reticulum membrane]
(Sus scrofa)
ACAT [endoplasmic reticulum membrane]
(Drosophila melanogaster)
soat1 [endoplasmic reticulum membrane]
(Danio rerio)
soat1 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENSP00000445315
,
ENSP00000441356
,
ENSP00000356591
,
ENST00000540564
,
ENST00000367619
,
ENST00000539888
OpenTargets
ENSG00000057252
ZINC - Substances
SOAT1_HUMAN
ZINC - Biogenic
SOAT1_HUMAN
ZINC target
P35610
PRO
P35610
GlyGen
P35610
PDB
6L47
,
6P2P
,
6VUM
,
6L48
,
6P2J
ZINC - Investigational
SOAT1_HUMAN
ZINC - Metabolites
SOAT1_HUMAN
HPA
ENSG00000057252-SOAT1
Pharos - Targets
P35610
ZINC - Predictions - Purchasable
SOAT1_HUMAN
HMDB Protein
HMDBP00504
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27824 CANX
2
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
0.615
4
UniProt:Q8N4J0 CARNMT1
1
CARNMT1 [cytosol]
(R-HSA-8876689)
0.589
2
UniProt:O75326 SEMA7A
1
SEMA7A [plasma membrane]
(R-HSA-198229)
0.527
2
UniProt:P31930 UQCRC1
1
UQCRC1 [mitochondrial inner membrane]
(R-HSA-164284)
0.508
2
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