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NCSTN [endosome membrane]
Stable Identifier
R-HSA-9010085
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endosome membrane
Synonyms
Nicastrin, NICA_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713) (Homo sapiens)
gamma-secretase complex [endosome membrane] (Homo sapiens)
NCSTN [endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92542 NCSTN
Gene Names
NCSTN, KIAA0253, UNQ1874/PRO4317
Chain
signal peptide:1-33, chain:34-709
Reference Genes
BioGPS Gene:23385 NCSTN
COSMIC (genes):NCSTN NCSTN
CTD Gene:23385 NCSTN
dbSNP Gene:23385 NCSTN
ENSEMBL:ENSG00000162736 NCSTN
ENSEMBL_homo_sapiens_GENE:ENSG00000162736.18 NCSTN
HGNC:17091 NCSTN
KEGG Gene (Homo sapiens):23385 NCSTN
Monarch:23385 NCSTN
NCBI Gene:23385 NCSTN
OMIM:605254 NCSTN
UCSC:Q92542 NCSTN
Reference Transcript
RefSeq:NM_015331.2 NCSTN
RefSeq:NM_001290186.1 NCSTN
RefSeq:NM_001290184.1 NCSTN
Other Identifiers
11715676_s_at
11715677_x_at
11749182_a_at
16672598
208759_PM_at
208759_at
23385
2363087
2363092
2363096
2363098
2363100
2363103
2363104
2363106
2363107
2363108
2363109
2363114
2363116
2363117
2363118
2363119
2363122
2363124
2363125
34835_at
7906576
A_23_P34402
D87442_at
GE57397
GO:0002262
GO:0002376
GO:0003824
GO:0004175
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005765
GO:0005768
GO:0005769
GO:0005773
GO:0005783
GO:0005794
GO:0005886
GO:0005925
GO:0006508
GO:0006509
GO:0007212
GO:0007215
GO:0007219
GO:0007220
GO:0007611
GO:0008021
GO:0008233
GO:0010008
GO:0010950
GO:0012501
GO:0016020
GO:0016485
GO:0016787
GO:0021549
GO:0022010
GO:0023052
GO:0030154
GO:0030534
GO:0030659
GO:0030674
GO:0031293
GO:0031410
GO:0032991
GO:0034205
GO:0035577
GO:0042098
GO:0042383
GO:0042470
GO:0042500
GO:0042734
GO:0042982
GO:0042983
GO:0042986
GO:0042987
GO:0043085
GO:0043226
GO:0048856
GO:0050435
GO:0050673
GO:0050877
GO:0051117
GO:0051402
GO:0051604
GO:0060090
GO:0070062
GO:0070765
GO:0070851
GO:0071277
GO:0097060
GO:0140096
GO:1900271
GO:1901135
GO:1990926
HMNXSV003002299
HMNXSV003055337
ILMN_1735180
PH_hs_0000488
g9992877_3p_at
Participates
as a component of
gamma-secretase complex [endosome membrane] (Homo sapiens)
Other forms of this molecule
NCSTN [plasma membrane]
NCSTN [azurophil granule membrane]
Cross References
RefSeq
NP_001277115.1
,
NP_001277113.1
,
NP_056146.1
OpenTargets
ENSG00000162736
HPA
ENSG00000162736-NCSTN
GeneCards
Q92542
Ensembl
ENSP00000294785
,
ENSG00000162736
,
ENST00000294785
PRO
Q92542
Pharos - Targets
Q92542
Orphanet
20181
PDB
5FN4
,
2N7R
,
5A63
,
6LR4
,
7D8X
,
7Y5X
,
6IYC
,
2N7Q
,
5FN3
,
7Y5T
,
4UIS
,
5FN2
,
6LQG
,
7C9I
,
6IDF
,
7Y5Z
,
5FN5
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35613 BSG
2
BSG [Golgi membrane]
(R-HSA-204478)
BSG [plasma membrane]
(R-HSA-197673)
0.591
6
UniProt:Q15363 TMED2
5
TMED2 [Golgi membrane]
(R-HSA-6808804)
TMED2 [transport vesicle]
(R-HSA-6808806)
TMED2 [ER to Golgi transport vesicle membrane]
(R-HSA-5689847)
TMED2 [endoplasmic reticulum membrane]
(R-HSA-5689480)
TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-1911531)
0.524
2
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