Reactome | NCSTN [endosome membrane]

NCSTN [endosome membrane]

Stable Identifier

R-HSA-9010085

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

Nicastrin, NICA_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q92542 NCSTN

Gene Names

NCSTN, KIAA0253, UNQ1874/PRO4317

Chain

signal peptide:1-33, chain:34-709

Reference Genes

BioGPS Gene:23385 NCSTN

COSMIC (genes):NCSTN NCSTN

CTD Gene:23385 NCSTN

dbSNP Gene:23385 NCSTN

ENSEMBL:ENSG00000162736 NCSTN

HGNC:17091 NCSTN

KEGG:hsa:23385 NCSTN

Monarch:23385 NCSTN

NCBI Gene:23385 NCSTN

OMIM:605254 NCSTN

UCSC:Q92542 NCSTN

Reference Transcript

Other Identifiers

11715676_s_at

11715677_x_at

11749182_a_at

16672598

208759_PM_at

208759_at

23385

2363085

2363086

2363087

2363088

2363089

2363090

2363091

2363092

2363093

2363094

2363095

2363096

2363097

2363098

2363099

2363100

2363101

2363102

2363103

2363104

2363105

2363106

2363107

2363108

2363109

2363110

2363111

2363112

2363113

2363114

2363115

2363116

2363117

2363118

2363119

2363120

2363121

2363122

2363123

2363124

2363125

237076_PM_at

237076_at

34835_at

7906576

86276_at

A_23_P34402

D87442_at

GE57397

GO:0000139

GO:0002262

GO:0002376

GO:0003824

GO:0004175

GO:0005515

GO:0005764

GO:0005765

GO:0005768

GO:0005769

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0005886

GO:0005925

GO:0006508

GO:0006509

GO:0007212

GO:0007215

GO:0007219

GO:0007220

GO:0007611

GO:0008021

GO:0008233

GO:0010008

GO:0010950

GO:0012501

GO:0016020

GO:0016485

GO:0016787

GO:0021549

GO:0022010

GO:0030534

GO:0030659

GO:0030674

GO:0031293

GO:0031410

GO:0032991

GO:0034205

GO:0035577

GO:0042098

GO:0042383

GO:0042470

GO:0042500

GO:0042734

GO:0042982

GO:0042983

GO:0042986

GO:0042987

GO:0043226

GO:0048856

GO:0050435

GO:0050673

GO:0050877

GO:0051117

GO:0051402

GO:0051604

GO:0060090

GO:0070062

GO:0070765

GO:0070851

GO:0071277

GO:0097060

GO:0140096

GO:1900271

GO:1990926

HMNXSV003002299

HMNXSV003055337

Hs.195567.0.A1_3p_at

ILMN_1735180

PH_hs_0000488

TC01001367.hg

g9992877_3p_at

Participates

as a component of

gamma-secretase complex [endosome membrane] (Homo sapiens)

Other forms of this molecule

NCSTN [plasma membrane]

NCSTN [azurophil granule membrane]

Cross References

RefSeq

NP_056146.1, NP_001277115.1, NP_001277113.1

OpenTargets

ENSG00000162736

ENSEMBL

ENST00000294785, ENSP00000294785

HPA

ENSG00000162736-NCSTN

PRO

Q92542

Pharos - Targets

Q92542

Orphanet

NCSTN

GlyGen

Q92542

PDB

8OQZ, 8K8E, 7Y5T, 5A63, 6LR4, 5FN5, 4UIS, 6LQG, 7Y5Z, 2N7R, 2N7Q, 7Y5X, 7D8X, 8IM7, 5FN2, 6IDF, 8X53, 6IYC, 5FN3, 5FN4, 7C9I, 8OQY, 8X54, 8X52

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35613 BSG	2	BSG [plasma membrane] (R-HSA-197673) BSG [Golgi membrane] (R-HSA-204478)	0.591	6
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.527	2
UniProt:Q15363 TMED2	5	TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-1911531) TMED2 [endoplasmic reticulum membrane] (R-HSA-5689480) TMED2 [ER to Golgi transport vesicle membrane] (R-HSA-5689847) TMED2 [transport vesicle] (R-HSA-6808806) TMED2 [Golgi membrane] (R-HSA-6808804)	0.524	2