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Glycosylation and Folding of HA
Stable Identifier
R-HSA-169921
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
endoplasmic reticulum lumen
,
endoplasmic reticulum membrane
ReviewStatus
5/5
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Influenza Infection (Homo sapiens)
Virus Assembly and Release (Homo sapiens)
Assembly of Viral Components at the Budding Site (Homo sapiens)
Glycosylation and Folding of HA (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The ectodomain of HA is translocated into the ER lumen, where it undergoes a series of folding events mediated by the formation of disulfide bonds and glycosylation reactions. The formation of a discrete intermediate species of highly folded monomeric protein preceeds trimerisation. The folding process is efficient and rapid, with greater than 90% of the protein trafficked to the golgi apparatus; and mature HA0 subunits appearing in a matter of a few minutes. Calnexin and calreticulin have been identified as cellular lectins which interact transiently with newly synthesized HA by attaching to partially trimmed N-linked oligosaccharides (Herbert et al., 1997), facilitating correct folding of the HA molecule.
Literature References
PubMed ID
Title
Journal
Year
10764645
Chaperone selection during glycoprotein translocation into the endoplasmic reticulum
Helenius, A
,
Molinari, M
Science
2000
12535523
N-linked glycans direct the cotranslational folding pathway of influenza hemagglutinin
Kurowski, B
,
Daniels, R
,
Johnson, AE
,
Hebert, DN
Mol Cell
2003
Participants
Input
HA [endoplasmic reticulum membrane]
(Influenza A virus)
Output
Glycosylated and folded HA [endoplasmic reticulum membrane]
(Influenza A virus)
Participates
as an event of
Assembly of Viral Components at the Budding Site (Homo sapiens)
This event is regulated
Positively by
Regulator
CANX [endoplasmic reticulum lumen]
(Homo sapiens)
Regulator
CALR [endoplasmic reticulum lumen]
(Homo sapiens)
Disease
Name
Identifier
Synonyms
influenza
DOID:8469
Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Steel, J (2007-05-01)
Reviewed
Squires, B (2007-05-01)
Rush, MG (2007-05-01)
Created
Gillespie, ME (2005-12-19)
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