Glycosylation and Folding of HA

Stable Identifier
R-HSA-169921
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
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The ectodomain of HA is translocated into the ER lumen, where it undergoes a series of folding events mediated by the formation of disulfide bonds and glycosylation reactions. The formation of a discrete intermediate species of highly folded monomeric protein preceeds trimerisation. The folding process is efficient and rapid, with greater than 90% of the protein trafficked to the golgi apparatus; and mature HA0 subunits appearing in a matter of a few minutes. Calnexin and calreticulin have been identified as cellular lectins which interact transiently with newly synthesized HA by attaching to partially trimmed N-linked oligosaccharides (Herbert et al., 1997), facilitating correct folding of the HA molecule.

Literature References
PubMed ID Title Journal Year
12535523 N-linked glycans direct the cotranslational folding pathway of influenza hemagglutinin

Daniels, R, Kurowski, B, Johnson, AE, Hebert, DN

Mol Cell 2003
10764645 Chaperone selection during glycoprotein translocation into the endoplasmic reticulum

Molinari, M, Helenius, A

Science 2000
Participants
Participant Of
This event is regulated
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
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