CANX:EBI3 [endoplasmic reticulum lumen]

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser

Calnexin (CANX or p95 calnexin) binds Interleukin-27 subunit beta (EBI3, IL27B). In human cell lines (BL30, BL41, Louckes, BJAB, P3HR1) most newly synthesized EBI3 is retained in the endoplasmic reticulum (ER) in an endoglycosidase H-sensitive form (Devergne et al. 1996, 1997), bound to CANX and a 60-kDa protein and transiently with a p75-kDa protein, both ignored here). EBI3 can be released by itself but the association with CANX prevents this, the complex is retained in the ER. The co-expression of other interleukin subunits enables the release of EBI3 in a complex with Interleukin-27 subunit alpha (IL27) (Devergne et al. 1996).

Literature References
PubMed ID Title Journal Year
8551575 A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes

Birkenbach, M, Le Beau, MM, Devergne, O, Kieff, E, Hummel, M, Koeppen, H, Nathanson, EC

J. Virol. 1996
9342359 Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

Birkenbach, M, Devergne, O, Kieff, E

Proc. Natl. Acad. Sci. U.S.A. 1997
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