Reactome | ATP6AP2 [ficolin-1-rich granule membrane]

ATP6AP2 [ficolin-1-rich granule membrane]

Stable Identifier

R-HSA-6800921

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ficolin-1-rich granule membrane

Synonyms

Prorenin receptor, Renin receptor, RENR_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O75787 ATP6AP2

Gene Names

ATP6AP2, ATP6IP2, CAPER, ELDF10, HT028, MSTP009, PSEC0072

Chain

signal peptide:1-16, chain:17-350, chain:17-275, chain:278-350

Reference Genes

BioGPS Gene:10159 ATP6AP2

COSMIC (genes):ATP6AP2 ATP6AP2

CTD Gene:10159 ATP6AP2

dbSNP Gene:10159 ATP6AP2

ENSEMBL:ENSG00000182220 ATP6AP2

HGNC:18305 ATP6AP2

KEGG:hsa:10159 ATP6AP2

Monarch:10159 ATP6AP2

NCBI Gene:10159 ATP6AP2

OMIM:300556 ATP6AP2

UCSC:O75787 ATP6AP2

Reference Transcript

RefSeq:NM_005765.2 ATP6AP2

Other Identifiers

10159

11715643_a_at

11715644_s_at

11747378_a_at

11747379_x_at

11750028_a_at

17102668

201443_PM_s_at

201443_s_at

201444_PM_s_at

201444_s_at

2373559

3974557

3974558

3974559

3974560

3974561

3974562

3974563

3974564

3974565

3974566

3974567

3974568

3974569

3974570

3974572

3974573

3974574

3974575

3974576

40903_at

8166805

A_14_P113151

A_23_P11353

GE80135

GO:0000139

GO:0000220

GO:0000421

GO:0002003

GO:0005515

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005783

GO:0005789

GO:0005886

GO:0007035

GO:0007042

GO:0009897

GO:0010008

GO:0016020

GO:0016471

GO:0021626

GO:0021903

GO:0030177

GO:0030424

GO:0030665

GO:0030672

GO:0031410

GO:0032591

GO:0032914

GO:0033176

GO:0038023

GO:0042995

GO:0043226

GO:0043231

GO:0043408

GO:0045202

GO:0045211

GO:0048069

GO:0048388

GO:0051452

GO:0051604

GO:0055085

GO:0060089

GO:0060323

GO:0061795

GO:0070062

GO:0070821

GO:0090263

GO:0097401

GO:0098588

GO:0101003

GO:1902600

HMNXSV003058180

ILMN_1677440

ILMN_1849199

PH_hs_0010821

TC0X000190.hg

g12005668_3p_at

g5031590_3p_a_at

Participates

as a member of

Ficolin-rich granule membrane proteins [ficolin-1-rich granule membrane] (Homo sapiens)

Other forms of this molecule

ATP6AP2 [plasma membrane]

ATP6AP2 [tertiary granule membrane]

Inferred To

Atp6ap2 [ficolin-1-rich granule membrane] (Mus musculus)

Atp6ap2 [ficolin-1-rich granule membrane] (Rattus norvegicus)

vha-20 [ficolin-1-rich granule membrane] (Caenorhabditis elegans)

ATP6AP2 [ficolin-1-rich granule membrane] (Bos taurus)

ATP6AP2 [ficolin-1-rich granule membrane] (Canis familiaris)

ATP6AP2 [ficolin-1-rich granule membrane] (Dictyostelium discoideum)

ATP6AP2 [ficolin-1-rich granule membrane] (Drosophila melanogaster)

ATP6AP2 [ficolin-1-rich granule membrane] (Gallus gallus)

ATP6AP2 [ficolin-1-rich granule membrane] (Sus scrofa)

atp6ap2 [ficolin-1-rich granule membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_005756.2

OpenTargets

ENSG00000182220

ENSEMBL

ENST00000636409, ENSP00000490083, ENSP00000489819, ENSG00000182220, ENST00000636580

HPA

ENSG00000182220-ATP6AP2

GeneCards

ATP6AP2

PRO

O75787

Pharos - Targets

O75787

Orphanet

ATP6AP2

PDB

6WM3, 6WM2, 7U4T, 3LC8, 6WLW, 3LBS, 6WM4

HMDB Protein

HMDBP12594

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15904 ATP6AP1	2	ATP6AP1 [endoplasmic reticulum membrane] (R-HSA-9714332) ATP6AP1 [endosome membrane] (R-HSA-5215981)	0.725	7
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.643	5
UniProt:P61421 ATPV0D1	3	ATP6V0D1 [endosome membrane] (R-HSA-912592) ATP6V0D1 [phagocytic vesicle membrane] (R-HSA-1222571) ATP6V0D1 [lysosomal membrane] (R-HSA-9640177)	0.643	3
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.569	4
UniProt:P21854 CD72	1	CD72 [plasma membrane] (R-HSA-198121)	0.556	3
UniProt:Q01453 PMP22	1	PMP22 [plasma membrane] (R-HSA-9615623)	0.556	3
UniProt:Q9NPL8 TIMMDC1	1	TIMMDC1 [mitochondrial inner membrane] (R-HSA-5689720)	0.556	3
UniProt:P21281 ATP6V1B2	1	ATP6V1B2 [cytosol] (R-HSA-912598)	0.527	2
UniProt:O75348 ATP6V1G1	1	ATP6V1G1 [cytosol] (R-HSA-912578)	0.527	2
UniProt:P38606 ATP6V1A	1	ATP6V1A [cytosol] (R-HSA-912602)	0.527	2
UniProt:P36543 ATP6V1E1	1	ATP6V1E1 [cytosol] (R-HSA-912606)	0.527	2
UniProt:P21283 ATP6V1C1	1	ATP6V1C1 [cytosol] (R-HSA-912586)	0.527	2
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.527	4

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