Reactome | AGT [extracellular region]

AGT [extracellular region]

Stable Identifier

R-HSA-1998759

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Angiotensinogen, ANGT_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P01019 AGT

Gene Names

AGT, SERPINA8

Chain

signal peptide:1-24, chain:25-476, peptide:25-34, peptide:25-33, peptide:25-32, peptide:25-31, peptide:25-29, peptide:25-28, peptide:26-32, peptide:27-32

Reference Genes

BioGPS Gene:183 AGT

COSMIC (genes):AGT AGT

CTD Gene:183 AGT

dbSNP Gene:183 AGT

ENSEMBL:ENSG00000135744 AGT

ENSEMBL_homo_sapiens_GENE:ENSG00000135744.9 AGT

HGNC:333 AGT

Monarch:183 AGT

NCBI Gene:183 AGT

UCSC:P01019 AGT

Reference Transcript

RefSeq:NM_000029.3 AGT

Other Identifiers

11730726_s_at

11749833_s_at

16700385

183

202834_PM_at

202834_at

2460290

2460291

2460293

2460295

2460297

2460298

2460299

2460300

2460301

2460302

2460305

2460307

2460308

2460309

684_at

7924987

A_23_P115261

GE80879

GO:0001558

GO:0001819

GO:0001822

GO:0001974

GO:0002016

GO:0002018

GO:0002019

GO:0002034

GO:0003012

GO:0003013

GO:0003014

GO:0003081

GO:0004867

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0005829

GO:0006351

GO:0006355

GO:0006954

GO:0007186

GO:0007199

GO:0007200

GO:0007263

GO:0007267

GO:0008083

GO:0008217

GO:0010536

GO:0010595

GO:0010613

GO:0010718

GO:0010744

GO:0012501

GO:0014873

GO:0019229

GO:0023052

GO:0030154

GO:0030198

GO:0030312

GO:0031012

GO:0031702

GO:0031703

GO:0033864

GO:0034330

GO:0034374

GO:0035813

GO:0036211

GO:0038166

GO:0042127

GO:0042310

GO:0042981

GO:0043226

GO:0043407

GO:0045742

GO:0045893

GO:0048018

GO:0048146

GO:0048856

GO:0048870

GO:0050729

GO:0050886

GO:0051092

GO:0051247

GO:0051387

GO:0051897

GO:0055065

GO:0061098

GO:0062023

GO:0070062

GO:0072562

GO:0090190

GO:0097746

GO:0098772

GO:1901201

GO:1901203

GO:1901394

GO:1902895

GO:1903598

GO:1903779

GO:1905920

GO:1990776

GO:2000379

GO:2001238

HMNXSV003046508

ILMN_1813530

K02215_at

PH_hs_0022023

TC01006281.hg

g4557286_3p_at

Participates

as an input of

as an output of

Expression of AGT (Homo sapiens)

Other forms of this molecule

AGT(36-41) [extracellular region]

AGT(35-41) [extracellular region]

AGT(34-40) [extracellular region]

AGT(34-42) [extracellular region]

AGT(34-43) [extracellular region]

AGT(34-41) [extracellular region]

Inferred To

Spn42Da [extracellular region] (Drosophila melanogaster)

Agt [extracellular region] (Mus musculus)

Agt [extracellular region] (Rattus norvegicus)

srp-6 [extracellular region] (Caenorhabditis elegans)

Spn28Da [extracellular region] (Drosophila melanogaster)

AGT [extracellular region] (Bos taurus)

AGT [extracellular region] (Caenorhabditis elegans)

AGT [extracellular region] (Canis familiaris)

AGT [extracellular region] (Gallus gallus)

AGT [extracellular region] (Sus scrofa)

Spn88Eb [extracellular region] (Drosophila melanogaster)

Spn27A [extracellular region] (Drosophila melanogaster)

srp-2 [extracellular region] (Caenorhabditis elegans)

Acp76A [extracellular region] (Drosophila melanogaster)

Spn100A [extracellular region] (Drosophila melanogaster)

Spn42Dd [extracellular region] (Drosophila melanogaster)

srp-8 [extracellular region] (Caenorhabditis elegans)

Spn43Aa [extracellular region] (Drosophila melanogaster)

Spn47C [extracellular region] (Drosophila melanogaster)

Dmel\CG43366 [extracellular region] (Drosophila melanogaster)

srp-7 [extracellular region] (Caenorhabditis elegans)

Spn42Db [extracellular region] (Drosophila melanogaster)

Spn75F [extracellular region] (Drosophila melanogaster)

Homologues of AGT [extracellular region] (Caenorhabditis elegans)

Homologues of AGT [extracellular region] (Drosophila melanogaster)

Spn28Db [extracellular region] (Drosophila melanogaster)

Spn55B [extracellular region] (Drosophila melanogaster)

nec [extracellular region] (Drosophila melanogaster)

Spn31A [extracellular region] (Drosophila melanogaster)

Spn43Ab [extracellular region] (Drosophila melanogaster)

Spn53F [extracellular region] (Drosophila melanogaster)

Spn88Ea [extracellular region] (Drosophila melanogaster)

srp-1 [extracellular region] (Caenorhabditis elegans)

Spn38F [extracellular region] (Drosophila melanogaster)

agt [extracellular region] (Danio rerio)

agt [extracellular region] (Xenopus tropicalis)

srp-3 [extracellular region] (Caenorhabditis elegans)

Spn42Dc [extracellular region] (Drosophila melanogaster)

Spn42De [extracellular region] (Drosophila melanogaster)

Spn28B [extracellular region] (Drosophila melanogaster)

Spn85F [extracellular region] (Drosophila melanogaster)

Spn28F [extracellular region] (Drosophila melanogaster)

Spn43Ad [extracellular region] (Drosophila melanogaster)

Cross References

RefSeq

NP_000020.1

OpenTargets

ENSG00000135744

HPA

ENSG00000135744-AGT

GeneCards

P01019

Ensembl

ENSP00000504866, ENST00000680041, ENST00000681269, ENST00000679738, ENST00000366667, ENSP00000505963, ENSP00000505063, ENSG00000135744, ENSP00000355627, ENST00000681514, ENSP00000505985

PRO

P01019

Pharos - Targets

P01019

Orphanet

15475

HMDB Protein

HMDBP02609

PDB

4AA1, 2WXW, 6JOD, 3WOR, 3CK0, 1N9V, 6I3F, 7C6A, 5M3Y, 4APH, 3WOO, 2X0B, 4FYS, 2JP8, 6I3I, 1N9U, 6OS0, 5M3X, 5XJM, 5E2Q

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q10714	2	ACE(30-1306) [plasma membrane] (R-DME-508496-2) ACE(30-1232) [extracellular region] (R-DME-2065414-2)	0.558	2
UniProt:P00797 REN	3	REN [plasma membrane] (R-HSA-2022352) REN(24-406) [plasma membrane] (R-HSA-2065391) REN [extracellular region] (R-HSA-2022343)	0.558	2
UniProt:Q9UMY4 SNX12			0.556	3
UniProt:Q9UI10 EIF2B4	1	EIF2B4 [cytosol] (R-HSA-72521)	0.556	3
UniProt:O43493-5 O434935			0.556	3
UniProt:Q8N0U8 VKORC1L1	1	VKORC1L1 [endoplasmic reticulum membrane] (R-HSA-2980944)	0.556	3
UniProt:C9J082 C9J082			0.556	3
UniProt:O00746 NME4	1	NME4 [mitochondrial inner membrane] (R-HSA-60026)	0.556	3
UniProt:Q8IYM2 SLN12			0.556	3
UniProt:CCDC26 A0A024R9H7			0.556	3
UniProt:Q8NFB2 T185A			0.556	3
UniProt:Q8TAS3 Q8TAS3			0.556	3
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [nucleoplasm] (R-HSA-5205609) PRMT5 [cytosol] (R-HSA-191876)	0.556	3
UniProt:O95167 NDUFA3	1	NDUFA3 [mitochondrial inner membrane] (R-HSA-60180)	0.527	2
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.527	2
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.527	2

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