Reactome | VRK2 [mitochondrial outer membrane]

VRK2 [mitochondrial outer membrane]

Stable Identifier

R-HSA-9715102

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q86Y07 VRK2

Gene Names

VRK2

Chain

chain:1-508

Reference Genes

BioGPS Gene:7444 VRK2

COSMIC (genes):VRK2 VRK2

CTD Gene:7444 VRK2

dbSNP Gene:7444 VRK2

ENSEMBL:ENSG00000028116 VRK2

HGNC:12719 VRK2

KEGG Gene (Homo sapiens):7444 VRK2

Monarch:7444 VRK2

NCBI Gene:7444 VRK2

OMIM:602169 VRK2

UCSC:Q86Y07 VRK2

Reference Transcript

Other Identifiers

0003990315

11742755_a_at

16880304

205126_at

2483452

2483453

2483458

2483459

2483460

2483462

2483463

2483465

2483466

2483479

2483481

2483483

2483484

2483485

2483489

2483491

2483498

2483500

2483501

2483503

2483504

2483508

2483509

2483510

33124_at

7444

8042086

AB000450_at

A_14_P107251

A_14_P120903

A_23_P119992

A_33_P3417990

GE53013

GO:0000166

GO:0003674

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005737

GO:0005739

GO:0005783

GO:0005789

GO:0006464

GO:0006468

GO:0006950

GO:0007165

GO:0008150

GO:0016020

GO:0016021

GO:0016032

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0019899

GO:0019901

GO:0019904

GO:0031966

GO:0032991

GO:0034599

GO:0043167

GO:0043226

GO:0043408

GO:0044403

GO:0046777

GO:0106310

GO:0106311

GO:2000659

HMNXSV003003736

HMNXSV003005102

HMNXSV003020600

ILMN_1750088

PH_hs_0004736

TC02000331.hg

TC02003252.hg

g5454163_3p_at

Participates

as a candidate of

RHOD mitochondrial outer membrane effectors [cytosol] (Homo sapiens)

Other forms of this molecule

VRK2 [endoplasmic reticulum membrane]

Inferred To

ball [mitochondrial outer membrane] (Drosophila melanogaster)

VRK2 [mitochondrial outer membrane] (Bos taurus)

VRK2 [mitochondrial outer membrane] (Canis familiaris)

VRK2 [mitochondrial outer membrane] (Gallus gallus)

VRK2 [mitochondrial outer membrane] (Sus scrofa)

Vrk2 [mitochondrial outer membrane] (Mus musculus)

Vrk2 [mitochondrial outer membrane] (Rattus norvegicus)

hhp1 [mitochondrial outer membrane] (Schizosaccharomyces pombe)

hhp2 [mitochondrial outer membrane] (Schizosaccharomyces pombe)

vrk2 [mitochondrial outer membrane] (Danio rerio)

Homologues of VRK2 [mitochondrial outer membrane] (Schizosaccharomyces pombe)

vrk-1 [mitochondrial outer membrane] (Caenorhabditis elegans)

HRR25 [mitochondrial outer membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001123954.1, NP_001123952.1, XP_006712153.1, NP_001275766.1, XP_006712155.1, NP_001275768.1, XP_016860348.1, XP_016860351.1, NP_001123953.1, XP_006712156.1, NP_001123955.1, XP_011531394.1, XP_006712154.1, NP_001275767.1, NP_001275765.1, XP_016860349.1, XP_016860347.1, XP_016860352.1, XP_016860350.1, XP_005264597.1, NP_006287.2

ZINC - World Drugs

VRK2_HUMAN

OpenTargets

ENSG00000028116

ZINC - FDA approved

VRK2_HUMAN

ZINC - Substances

VRK2_HUMAN

ZINC target

Q86Y07

PRO

Q86Y07

PDB

6NCG, 2V62, 5UU1

ZINC - Investigational

VRK2_HUMAN

HPA

ENSG00000028116-VRK2

GeneCards

Q86Y07

Ensembl

ENSP00000408002, ENSP00000402375, ENSP00000404156, ENST00000648897, ENST00000440705, ENSP00000497378, ENSP00000342381, ENST00000417641, ENST00000412104, ENSG00000028116, ENST00000340157, ENSP00000398323, ENST00000435505

ZINC - Predictions - Purchasable

VRK2_HUMAN

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.556	3
UniProt:Q02750 MAP2K1	27	MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) MAP2K1 Q56P [cytosol] (R-HSA-9652064) MAP2K1 E203K [cytosol] (R-HSA-9652023) MAP2K1 V60E [cytosol] (R-HSA-9652067) MAP2K1 P124S [cytosol] (R-HSA-9652062) MAP2K1 Y130C [cytosol] (R-HSA-9652101) MAP2K1 C121S [cytosol] (R-HSA-9652013) MAP2K1 G128V [cytosol] (R-HSA-9652047) MAP2K1 F53L [cytosol] (R-HSA-9652031) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 E44_E57del [cytosol] (R-HSA-9652026) MAP2K1 P124Q [cytosol] (R-HSA-9652058) MAP2K1 F53C [cytosol] (R-HSA-9652028) p-S,218, S222,T292 MAP2K1 [cytosol] (R-HSA-5674490) MAP2K1 [cytosol] (R-HSA-59502) p-T286,T292-MAP2K1 [cytosol] (R-HSA-112374) p-S218,S222,T286,T292-MAP2K1 [cytosol] (R-HSA-112339) p-S218,S222-MAP2K1 [cytosol] (R-HSA-109837)	0.524	2

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