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VRK2 [mitochondrial outer membrane]
Stable Identifier
R-HSA-9715102
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOD GTPase cycle (Homo sapiens)
RHOD binds effectors at the mitochondrial outer membrane (Homo sapiens)
RHOD mitochondrial outer membrane effectors [cytosol] (Homo sapiens)
VRK2 [mitochondrial outer membrane] (Homo sapiens)
RHOD:GTP:RHOD mitochondrial outer membrane effectors [mitochondrial outer membrane] (Homo sapiens)
RHOD mitochondrial outer membrane effectors [cytosol] (Homo sapiens)
VRK2 [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86Y07 VRK2
Gene Names
VRK2
Chain
chain:1-508
Reference Genes
BioGPS Gene:7444 VRK2
COSMIC (genes):VRK2 VRK2
CTD Gene:7444 VRK2
dbSNP Gene:7444 VRK2
ENSEMBL:ENSG00000028116 VRK2
HGNC:12719 VRK2
KEGG Gene (Homo sapiens):7444 VRK2
Monarch:7444 VRK2
NCBI Gene:7444 VRK2
OMIM:602169 VRK2
UCSC:Q86Y07 VRK2
Reference Transcript
RefSeq:NM_001130480.2 VRK2
RefSeq:NM_001130482.2 VRK2
RefSeq:XM_011533092.2 VRK2
RefSeq:XM_006712090.3 VRK2
RefSeq:NM_001288838.1 VRK2
RefSeq:NM_006296.6 VRK2
RefSeq:NM_001288836.1 VRK2
RefSeq:XM_017004859.1 VRK2
RefSeq:XM_017004861.1 VRK2
RefSeq:XM_006712092.3 VRK2
RefSeq:XM_017004863.1 VRK2
RefSeq:NM_001130481.2 VRK2
RefSeq:XM_017004858.1 VRK2
RefSeq:NM_001288839.1 VRK2
RefSeq:XM_006712091.3 VRK2
RefSeq:XM_017004862.1 VRK2
RefSeq:NM_001130483.2 VRK2
RefSeq:XM_006712093.3 VRK2
RefSeq:NM_001288837.1 VRK2
RefSeq:XM_005264540.4 VRK2
RefSeq:XM_017004860.1 VRK2
Other Identifiers
0003990315
11742755_a_at
16880304
205126_at
2483452
2483453
2483458
2483459
2483460
2483462
2483463
2483465
2483466
2483479
2483481
2483483
2483484
2483485
2483489
2483491
2483498
2483500
2483501
2483503
2483504
2483508
2483509
2483510
33124_at
7444
8042086
AB000450_at
A_14_P107251
A_14_P120903
A_23_P119992
A_33_P3417990
GE53013
GO:0000166
GO:0003674
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005737
GO:0005739
GO:0005783
GO:0005789
GO:0006464
GO:0006468
GO:0006950
GO:0007165
GO:0008150
GO:0016020
GO:0016021
GO:0016032
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0019899
GO:0019901
GO:0019904
GO:0031966
GO:0032991
GO:0034599
GO:0043167
GO:0043226
GO:0043408
GO:0044403
GO:0046777
GO:0106310
GO:0106311
GO:2000659
HMNXSV003003736
HMNXSV003005102
HMNXSV003020600
ILMN_1750088
PH_hs_0004736
TC02000331.hg
TC02003252.hg
g5454163_3p_at
Participates
as a candidate of
RHOD mitochondrial outer membrane effectors [cytosol] (Homo sapiens)
Other forms of this molecule
VRK2 [endoplasmic reticulum membrane]
Inferred To
ball [mitochondrial outer membrane]
(Drosophila melanogaster)
VRK2 [mitochondrial outer membrane]
(Bos taurus)
VRK2 [mitochondrial outer membrane]
(Canis familiaris)
VRK2 [mitochondrial outer membrane]
(Gallus gallus)
VRK2 [mitochondrial outer membrane]
(Sus scrofa)
Vrk2 [mitochondrial outer membrane]
(Mus musculus)
Vrk2 [mitochondrial outer membrane]
(Rattus norvegicus)
hhp1 [mitochondrial outer membrane]
(Schizosaccharomyces pombe)
hhp2 [mitochondrial outer membrane]
(Schizosaccharomyces pombe)
vrk2 [mitochondrial outer membrane]
(Danio rerio)
Homologues of VRK2 [mitochondrial outer membrane]
(Schizosaccharomyces pombe)
vrk-1 [mitochondrial outer membrane]
(Caenorhabditis elegans)
HRR25 [mitochondrial outer membrane]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_001123954.1
,
NP_001123952.1
,
XP_006712153.1
,
NP_001275766.1
,
XP_006712155.1
,
NP_001275768.1
,
XP_016860348.1
,
XP_016860351.1
,
NP_001123953.1
,
XP_006712156.1
,
NP_001123955.1
,
XP_011531394.1
,
XP_006712154.1
,
NP_001275767.1
,
NP_001275765.1
,
XP_016860349.1
,
XP_016860347.1
,
XP_016860352.1
,
XP_016860350.1
,
XP_005264597.1
,
NP_006287.2
ZINC - World Drugs
VRK2_HUMAN
OpenTargets
ENSG00000028116
ZINC - FDA approved
VRK2_HUMAN
ZINC - Substances
VRK2_HUMAN
ZINC target
Q86Y07
PRO
Q86Y07
PDB
6NCG
,
2V62
,
5UU1
ZINC - Investigational
VRK2_HUMAN
HPA
ENSG00000028116-VRK2
GeneCards
Q86Y07
Ensembl
ENSP00000408002
,
ENSP00000402375
,
ENSP00000404156
,
ENST00000648897
,
ENST00000440705
,
ENSP00000497378
,
ENSP00000342381
,
ENST00000417641
,
ENST00000412104
,
ENSG00000028116
,
ENST00000340157
,
ENSP00000398323
,
ENST00000435505
ZINC - Predictions - Purchasable
VRK2_HUMAN
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8N4V1 MMGT1
1
MMGT1 [Golgi membrane]
(R-HSA-5216137)
0.556
3
UniProt:Q02750 MAP2K1
27
MAP2K1(2-8) [cytosol]
(R-HSA-5211342)
MAP2K1(9-393) [cytosol]
(R-HSA-5211353)
MAP2K1 F53S [cytosol]
(R-HSA-9652034)
MAP2K1 D67N [cytosol]
(R-HSA-9652016)
MAP2K1 Q56P [cytosol]
(R-HSA-9652064)
MAP2K1 E203K [cytosol]
(R-HSA-9652023)
MAP2K1 V60E [cytosol]
(R-HSA-9652067)
MAP2K1 P124S [cytosol]
(R-HSA-9652062)
MAP2K1 Y130C [cytosol]
(R-HSA-9652101)
MAP2K1 C121S [cytosol]
(R-HSA-9652013)
MAP2K1 G128V [cytosol]
(R-HSA-9652047)
MAP2K1 F53L [cytosol]
(R-HSA-9652031)
MAP2K1 K57N [cytosol]
(R-HSA-9652050)
MAP2K1 K57T [cytosol]
(R-HSA-9652052)
MAP2K1 F53V [cytosol]
(R-HSA-9652038)
MAP2K1 D67Y [cytosol]
(R-HSA-9652019)
MAP2K1 G128D [cytosol]
(R-HSA-9652043)
MAP2K1 P124L [cytosol]
(R-HSA-9652056)
MAP2K1 F53Y [cytosol]
(R-HSA-9652041)
MAP2K1 E44_E57del [cytosol]
(R-HSA-9652026)
MAP2K1 P124Q [cytosol]
(R-HSA-9652058)
MAP2K1 F53C [cytosol]
(R-HSA-9652028)
p-S,218, S222,T292 MAP2K1 [cytosol]
(R-HSA-5674490)
MAP2K1 [cytosol]
(R-HSA-59502)
p-T286,T292-MAP2K1 [cytosol]
(R-HSA-112374)
p-S218,S222,T286,T292-MAP2K1 [cytosol]
(R-HSA-112339)
p-S218,S222-MAP2K1 [cytosol]
(R-HSA-109837)
0.524
2
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