Reactome | WWOX [cytosol]

WWOX [cytosol]

Stable Identifier

R-HSA-1253335

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

WW domain-containing oxidoreductase, FOR, WOX1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9NZC7 WWOX

Gene Names

WWOX, FOR, SDR41C1, WOX1

Chain

chain:1-414

Reference Genes

BioGPS Gene:51741 WWOX

COSMIC - genes:WWOX WWOX

CTD Gene:51741 WWOX

dbSNP Gene:51741 WWOX

ENSEMBL:ENSG00000186153 WWOX

HGNC:12799 WWOX

KEGG:hsa:51741 WWOX

Monarch:51741 WWOX

NCBI Gene:51741 WWOX

OMIM:605131 WWOX

UCSC:Q9NZC7 WWOX

Reference Transcript

Participates

as an input of

as a component of

Inferred To

WWOX [cytosol] (Bos taurus)

WWOX [cytosol] (Caenorhabditis elegans)

WWOX [cytosol] (Canis familiaris)

WWOX [cytosol] (Danio rerio)

WWOX [cytosol] (Drosophila melanogaster)

WWOX [cytosol] (Gallus gallus)

WWOX [cytosol] (Mus musculus)

WWOX [cytosol] (Sus scrofa)

Ghost homologue of WWOX [cytosol] (Xenopus tropicalis)

Wwox [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001278926.1, NP_057457.1, NP_570607.1

OpenTargets

ENSG00000186153

ENSEMBL

ENSP00000384238, ENST00000355860, ENSP00000457230, ENST00000566780, ENSP00000384495, ENSP00000386161, ENST00000569818, ENSP00000454485, ENSG00000186153, ENST00000406884, ENST00000408984, ENST00000402655, ENSP00000348119

HPA

ENSG00000186153-WWOX

GeneCards

WWOX

PRO

Q9NZC7

Pharos - Targets

Q9NZC7

Orphanet

WWOX

PDB

1WMV

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P81408 EREP3			0.723	6
UniProt:Q96AW1 VOPP1			0.693	7
UniProt:Q96G27 WBP1			0.688	4
UniProt:O15350 TP73	3	TP73 [nucleoplasm] (R-HSA-6798094) TP73 [cytosol] (R-HSA-8957239) PolyUb-TP73 [cytosol] (R-HSA-8957256)	0.641	4
UniProt:O15350-2 TP73			0.61	5
UniProt:Q99732 LITAF			0.61	5
UniProt:P27824 CANX	3	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum membrane] (R-HSA-9932989)	0.569	3
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) DVL2 [cytosol] (R-HSA-201694) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) ub-DVL2 [cytosol] (R-HSA-4652689)	0.564	2
UniProt:P98153 IDD			0.527	2
UniProt:Q96B67 ARRD3			0.527	2
UniProt:Q5T700 LRAD1			0.527	2
UniProt:Q8N114 SHISA5	2	SHISA5 [endoplasmic reticulum lumen] (R-HSA-8956782) p-SHISA5 [endoplasmic reticulum lumen] (R-HSA-8956987)	0.524	2
UniProt:O15350-1 TP73			0.463	3
UniProt:Q67FY2	1	Bcl9l [nucleoplasm] (R-MMU-3305843)	0.463	3
UniProt:Q61527	14	phospho-ERBB4jmAcyt1s80 [mitochondrial matrix] (R-MMU-1254405) phospho-ERBB4jmAcyt2s80 [mitochondrial matrix] (R-MMU-1254387) phospho-ERBB4jmAcyt2s80 [nucleoplasm] (R-MMU-1252010) phospho-ERBB4jmAcyt1s80 [nucleoplasm] (R-MMU-1252017) phospho-ERBB4jmAcyt1s80 [cytosol] (R-MMU-1251964) phospho-ERBB4jmAcyt2s80 [cytosol] (R-MMU-1251987) phospho-ERBB4jmAcyt2m80 [plasma membrane] (R-MMU-1251984) phospho-ERBB4jmAcyt1m80 [plasma membrane] (R-MMU-1252004) phospho-p-Y1172,Y1226-ERBB4 JM-A CYT-2 isoform [plasma membrane] (R-MMU-1250307) ERBB4 JM-A CYT-1 isoform [plasma membrane] (R-MMU-1227940) ERBB4 JM-B CYT-1 isoform [plasma membrane] (R-MMU-1233232) ERBB4 JM-A CYT-2 isoform [plasma membrane] (R-MMU-1233237) phospho-p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform [plasma membrane] (R-MMU-1250319) phospho-p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform [plasma membrane] (R-MMU-1250313)	0.463	3

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