Reactome | ATP6AP1 [endosome membrane]

ATP6AP1 [endosome membrane]

Stable Identifier

R-HSA-5215981

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

V-type proton ATPase subunit S1, VAS1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q15904 ATP6AP1

Gene Names

ATP6AP1, ATP6IP1, ATP6S1, VATPS1, XAP3

Chain

signal peptide:1-41, chain:42-470, propeptide:42-231

Reference Genes

BioGPS Gene:537 ATP6AP1

COSMIC (genes):ATP6AP1 ATP6AP1

CTD Gene:537 ATP6AP1

dbSNP Gene:537 ATP6AP1

ENSEMBL:ENSG00000071553 ATP6AP1

HGNC:868 ATP6AP1

KEGG:hsa:537 ATP6AP1

Monarch:537 ATP6AP1

NCBI Gene:537 ATP6AP1

OMIM:300197 ATP6AP1

UCSC:Q15904 ATP6AP1

Reference Transcript

Other Identifiers

11747307_a_at

11749258_a_at

11754958_s_at

17108354

17108376

207809_PM_s_at

207809_s_at

35770_at

3996382

3996383

3996384

3996385

3996386

3996387

3996388

3996389

3996390

3996391

3996392

3996393

3996394

3996395

3996396

3996397

3996398

3996399

3996400

3996401

3996402

3996403

3996405

3996406

3996407

3996408

3996409

3996410

3996411

3996412

3996413

3996414

3996415

3996416

3996417

3996418

3996419

537

8170882

A_14_P115713

A_23_P250462

A_24_P74753

D16469_at

GE63290

GE79783

GO:0000139

GO:0001671

GO:0005515

GO:0005765

GO:0005783

GO:0005789

GO:0005886

GO:0006879

GO:0006886

GO:0007035

GO:0007042

GO:0010008

GO:0016020

GO:0016192

GO:0016469

GO:0030641

GO:0030665

GO:0030672

GO:0031267

GO:0031410

GO:0033116

GO:0033176

GO:0036035

GO:0036295

GO:0043226

GO:0045202

GO:0048388

GO:0048856

GO:0051452

GO:0055085

GO:0061795

GO:0070062

GO:0072659

GO:0097401

GO:0098772

GO:0098793

GO:0099638

GO:0141109

GO:1902600

HMNXSV003029783

ILMN_1697694

TC0X000771.hg

TC0X001937.hg

g4557340_3p_s_at

Participates

as an input of

ATP6AP1 binds V-ATPase (Homo sapiens)

as a component of

V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)

Other forms of this molecule

ATP6AP1 [endoplasmic reticulum membrane]

Inferred To

Ghost homologue of ATP6AP1 [endosome membrane] (Danio rerio)

Ghost homologue of ATP6AP1 [endosome membrane] (Dictyostelium discoideum)

Ghost homologue of ATP6AP1 [endosome membrane] (Gallus gallus)

Ghost homologue of ATP6AP1 [endosome membrane] (Plasmodium falciparum)

Ghost homologue of ATP6AP1 [endosome membrane] (Saccharomyces cerevisiae)

Ghost homologue of ATP6AP1 [endosome membrane] (Schizosaccharomyces pombe)

VhaAC45 [endosome membrane] (Drosophila melanogaster)

atp6ap1.2 [endosome membrane] (Xenopus tropicalis)

vha-19 [endosome membrane] (Caenorhabditis elegans)

ATP6AP1 [endosome membrane] (Bos taurus)

ATP6AP1 [endosome membrane] (Canis familiaris)

ATP6AP1 [endosome membrane] (Sus scrofa)

Atp6ap1 [endosome membrane] (Mus musculus)

Atp6ap1 [endosome membrane] (Rattus norvegicus)

Cross References

RefSeq

XP_011529481.1, NP_001174.2

ENSEMBL

ENST00000369762, ENSP00000358777

OpenTargets

ENSG00000071553

ZINC - Substances

VAS1_HUMAN

ZINC - Biogenic

VAS1_HUMAN

ZINC target

Q15904

PRO

Q15904

GlyGen

Q15904

PDB

6WM4, 6WLW, 7U4T, 7UNF, 6WM2, 6WM3

HPA

ENSG00000071553-ATP6AP1

Pharos - Targets

Q15904

ZINC - Predictions - Purchasable

VAS1_HUMAN

HMDB Protein

HMDBP09536

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTD1-PRO_0000449624 REP			0.832	12
UniProt:O75787 ATP6AP2	3	ATP6AP2 [tertiary granule membrane] (R-HSA-6799717) ATP6AP2 [ficolin-1-rich granule membrane] (R-HSA-6800921) ATP6AP2 [plasma membrane] (R-HSA-2022356)	0.725	7
UniProt:Q9Y487 ATP6V0A2	2	ATP6V0A2 [phagocytic vesicle membrane] (R-HSA-1222546) ATP6V0A2 [endosome membrane] (R-HSA-912595)	0.643	4
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.569	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P61421 ATPV0D1	3	ATP6V0D1 [endosome membrane] (R-HSA-912592) ATP6V0D1 [phagocytic vesicle membrane] (R-HSA-1222571) ATP6V0D1 [lysosomal membrane] (R-HSA-9640177)	0.527	2
UniProt:atp6v0d_human EBI-27062249			0.527	2
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.527	2
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.527	4
UniProt:Q93050 ATP6V0A1	5	ATP6V0A1 [secretory granule membrane] (R-HSA-6801281) ATP6V0A1 [plasma membrane] (R-HSA-6806520) ATP6V0A1 [ficolin-1-rich granule membrane] (R-HSA-6801296) ATP6V0A1 [phagocytic vesicle membrane] (R-HSA-1222308) ATP6V0A1 [endosome membrane] (R-HSA-912596)	0.527	2

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